INT87775

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Context Info
Confidence 0.82
First Reported 2000
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 15
Disease Relevance 2.75
Pain Relevance 6.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Gja1) Golgi apparatus (Gja1) transmembrane transport (Gja1)
cell-cell signaling (Gja1) cytoplasm (Gja1) signal transducer activity (Gja1)
Anatomy Link Frequency
uterine 5
spinal cord 3
myocardium 2
Nerve 1
neural 1
Gja1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Peripheral nerve stimulation 10 99.92 Very High Very High Very High
Sciatic nerve 15 99.84 Very High Very High Very High
Dorsal horn 25 99.68 Very High Very High Very High
Spinal cord 20 99.68 Very High Very High Very High
Dismenorea 28 99.52 Very High Very High Very High
nociceptor 10 99.02 Very High Very High Very High
qutenza 10 98.92 Very High Very High Very High
c fibre 10 98.40 Very High Very High Very High
ischemia 18 98.36 Very High Very High Very High
Opioid 3 98.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Dysmenorrhea 28 99.52 Very High Very High Very High
Cv Unclassified Under Development 18 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of fibres in rat sciatic nerve alters phosphorylation state of connexin-43 at astrocytic gap junctions in spinal cord: evidence for junction regulation by neuronal-glial interactions.
Phosphorylation (phosphorylation) of connexin-43 in spinal cord associated with nociceptor, sciatic nerve and spinal cord
1) Confidence 0.82 Published 2000 Journal Neuroscience Section Title Doc Link 10771343 Disease Relevance 0 Pain Relevance 0.67
The effect of peripheral nerve stimulation on connexin-43 phosphorylation state in the spinal cord of rats was examined with a monoclonal antibody (designated 13-8300) shown previously to recognize selectively a dephosphorylated form of connexin-43.
Phosphorylation (phosphorylation) of connexin-43 in spinal cord associated with peripheral nerve stimulation and spinal cord
2) Confidence 0.82 Published 2000 Journal Neuroscience Section Abstract Doc Link 10771343 Disease Relevance 0 Pain Relevance 0.32
The present study examined the hypothesis that inhibition of myometrial gap junctions through MAPK1-induced phosphorylation of GJA1 (connexin43) leads to inhibition of spontaneous phasic uterine contractions by 2,2'-dichlorobiphenyl (2,2'-DCB).
Phosphorylation (phosphorylation) of connexin43 in uterine associated with dismenorea
3) Confidence 0.81 Published 2005 Journal Biol. Reprod. Section Abstract Doc Link 16000550 Disease Relevance 0.17 Pain Relevance 0.17
However, there was no difference in phosphorylation of GJA1 at S368, a PRKC site.
Phosphorylation (hosphorylation ) of GJA1
4) Confidence 0.81 Published 2005 Journal Biol. Reprod. Section Abstract Doc Link 16000550 Disease Relevance 0.21 Pain Relevance 0.28
2,2'-Dichlorobiphenyl decreases amplitude and synchronization of uterine contractions through MAPK1-mediated phosphorylation of GJA1 (connexin43) and inhibition of myometrial gap junctions.
Phosphorylation (phosphorylation) of connexin43 in uterine associated with dismenorea
5) Confidence 0.81 Published 2005 Journal Biol. Reprod. Section Title Doc Link 16000550 Disease Relevance 0.19 Pain Relevance 0.19
Western blotting showed about a 4.5-fold increase in phosphorylation of GJA1 at S255, a MAPK1 site, after exposure to 100 microM 2,2'-DCB compared to untreated and solvent controls.
Phosphorylation (hosphorylation ) of GJA1
6) Confidence 0.81 Published 2005 Journal Biol. Reprod. Section Abstract Doc Link 16000550 Disease Relevance 0.21 Pain Relevance 0.26
The present study examined the hypothesis that inhibition of myometrial gap junctions through MAPK1-induced phosphorylation of GJA1 (connexin43) leads to inhibition of spontaneous phasic uterine contractions by 2,2'-dichlorobiphenyl (2,2'-DCB).
Phosphorylation (phosphorylation) of GJA1 in uterine associated with dismenorea
7) Confidence 0.81 Published 2005 Journal Biol. Reprod. Section Abstract Doc Link 16000550 Disease Relevance 0.17 Pain Relevance 0.17
2,2'-Dichlorobiphenyl decreases amplitude and synchronization of uterine contractions through MAPK1-mediated phosphorylation of GJA1 (connexin43) and inhibition of myometrial gap junctions.
Phosphorylation (phosphorylation) of GJA1 in uterine associated with dismenorea
8) Confidence 0.81 Published 2005 Journal Biol. Reprod. Section Title Doc Link 16000550 Disease Relevance 0.19 Pain Relevance 0.19
Therefore, this study suggests that 2,2'-DCB decreases amplitude and synchronization of uterine contractions mediated through MAPK1-mediated phosphorylation of GJA1 and subsequent inhibition of myometrial gap junctions.
Phosphorylation (phosphorylation) of GJA1 in uterine associated with dismenorea
9) Confidence 0.80 Published 2005 Journal Biol. Reprod. Section Abstract Doc Link 16000550 Disease Relevance 0.27 Pain Relevance 0.27
Delta-opioid receptor activation before ischemia reduces gap junction permeability in ischemic myocardium by PKC-epsilon-mediated phosphorylation of connexin 43.
Phosphorylation (phosphorylation) of connexin 43 in myocardium associated with ischemia and opioid receptor
10) Confidence 0.80 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Title Doc Link 17513490 Disease Relevance 0.48 Pain Relevance 0.55
These results suggest that phosphorylation of Cx43 by PKC-epsilon plays a crucial role in delta-opioid-induced suppression of GJ permeability in ischemic myocardium and that this modulation of the GJ is possibly an adjunct mechanism of infarct size limitation afforded by preischemic delta-opioid receptor activation.
Phosphorylation (phosphorylation) of Cx43 in myocardium associated with opioid receptor and opioid
11) Confidence 0.74 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 17513490 Disease Relevance 0.36 Pain Relevance 0.50
After DADLE infusion, PKC-epsilon, but not PKC-delta, was coimmunoprecipitated with Cx43, and the level of phosphorylation of Cx43 at a PKC-dependent site (Ser(368)) was significantly elevated during ischemia.
Phosphorylation (phosphorylation) of Cx43 associated with ischemia
12) Confidence 0.74 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 17513490 Disease Relevance 0.50 Pain Relevance 0.56
Nerve stimulation increased the number of 13-8300-positive astrocytic gap junctions, as well as the levels of dephosphorylated connexin-43 in the dorsal horn on the stimulated side.
Phosphorylation (dephosphorylated) of connexin-43 in Nerve associated with dorsal horn
13) Confidence 0.63 Published 2000 Journal Neuroscience Section Abstract Doc Link 10771343 Disease Relevance 0 Pain Relevance 1.00
The effect of peripheral nerve stimulation on connexin-43 phosphorylation state in the spinal cord of rats was examined with a monoclonal antibody (designated 13-8300) shown previously to recognize selectively a dephosphorylated form of connexin-43.
Phosphorylation (dephosphorylated) of connexin-43 in spinal cord associated with peripheral nerve stimulation and spinal cord
14) Confidence 0.63 Published 2000 Journal Neuroscience Section Abstract Doc Link 10771343 Disease Relevance 0 Pain Relevance 0.46
Sciatic nerve transection produced results similar to those seen after C-fibre activation with capsaicin.Thus, peripheral nerve stimulation evokes astrocytic connexin-43 dephosphorylation in the spinal cord dorsal horn, suggesting that gap junctional coupling between astrocytes in vivo is subject to regulation by neuronal-glial interactions following neural activation.
Phosphorylation (dephosphorylation) of connexin-43 in neural associated with c fibre, peripheral nerve stimulation, qutenza, dorsal horn, sciatic nerve and spinal cord
15) Confidence 0.55 Published 2000 Journal Neuroscience Section Abstract Doc Link 10771343 Disease Relevance 0 Pain Relevance 0.95

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