INT87778

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Context Info
Confidence 0.69
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.46
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Gja1) Golgi apparatus (Gja1) transmembrane transport (Gja1)
cell-cell signaling (Gja1) cytoplasm (Gja1) signal transducer activity (Gja1)
Anatomy Link Frequency
myocardium 2
Nerve 2
oocytes 2
cortex 2
frontal cortex 2
Gja1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn 5 99.68 Very High Very High Very High
Paracetamol 6 99.20 Very High Very High Very High
fluoxetine 5 98.64 Very High Very High Very High
Sciatic nerve 3 96.48 Very High Very High Very High
qutenza 2 95.40 Very High Very High Very High
c fibre 2 94.88 High High
depression 2 90.76 High High
tetrodotoxin 1 89.44 High High
Peripheral nerve stimulation 2 87.60 High High
Spinal cord 4 80.88 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 5 99.88 Very High Very High Very High
Hepatotoxicity 4 99.50 Very High Very High Very High
Urological Neuroanatomy 2 99.48 Very High Very High Very High
Glioma 1 99.34 Very High Very High Very High
Autism 2 91.44 High High
Depression 2 90.76 High High
Targeted Disruption 4 85.56 High High
Disease Progression 1 80.80 Quite High
Hypertrophy 6 77.52 Quite High
Obesity 3 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using SDS-PAGE and western blotting technique, we observed that CX43 protein expression in prefrontal cortex was significantly increased following chronic treatment with fluoxetine and clozapine, while it was significantly decreased by haloperidol and lithium.
Positive_regulation (increased) of Gene_expression (expression) of CX43 in cortex associated with fluoxetine
1) Confidence 0.69 Published 2008 Journal Schizophr. Res. Section Abstract Doc Link 18585900 Disease Relevance 0.25 Pain Relevance 0.24
These results suggest that APAP hepatotoxicity involves apoptosis, and induction of Cx43 expression may play an important role in the apoptotic signaling.
Positive_regulation (induction) of Gene_expression (expression) of Cx43 associated with paracetamol, hepatotoxicity and apoptosis
2) Confidence 0.67 Published 2010 Journal Toxicol Pathol Section Abstract Doc Link 20097795 Disease Relevance 0.75 Pain Relevance 0.51
Chronic psychotropic drug treatment causes differential expression of connexin 43 and GFAP in frontal cortex of rats.
Positive_regulation (causes) of Gene_expression (expression) of connexin 43 in frontal cortex associated with urological neuroanatomy
3) Confidence 0.50 Published 2008 Journal Schizophr. Res. Section Title Doc Link 18585900 Disease Relevance 0.28 Pain Relevance 0.21
Nerve stimulation increased the number of 13-8300-positive astrocytic gap junctions, as well as the levels of dephosphorylated connexin-43 in the dorsal horn on the stimulated side.
Positive_regulation (increased) of Gene_expression (levels) of connexin-43 in Nerve associated with dorsal horn
4) Confidence 0.47 Published 2000 Journal Neuroscience Section Abstract Doc Link 10771343 Disease Relevance 0 Pain Relevance 1.02
In the guinea pig, we have previously shown an age-dependent increase in SAN tissue lacking expression of Cx43 and Cav1.2 (major L-type Ca2+ channel isoform in working myocardium) [27,28].
Positive_regulation (increase) of Neg (lacking) Gene_expression (expression) of Cx43 in myocardium
5) Confidence 0.13 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.08 Pain Relevance 0.16
In fact, enhanced ATP release was observed in C6 glioma cells and epithelial HeLa cells overexpressing Cx43 [17–20] and in Xenopus oocytes transfected with Cx50 or Cx46 [21].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of Cx43 in oocytes associated with glioma
6) Confidence 0.07 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096548 Disease Relevance 0.10 Pain Relevance 0

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