INT8779

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Context Info
Confidence 0.47
First Reported 1986
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 50
Total Number 51
Disease Relevance 11.19
Pain Relevance 25.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TAC1) extracellular region (TAC1) plasma membrane (TAC1)
cell-cell signaling (TAC1)
Anatomy Link Frequency
nerve 4
brain 3
sperm 2
ovary 2
muscle 2
TAC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 333 100.00 Very High Very High Very High
antagonist 201 100.00 Very High Very High Very High
Neuropeptide 91 100.00 Very High Very High Very High
Pain 53 100.00 Very High Very High Very High
Calcitonin gene-related peptide 30 100.00 Very High Very High Very High
agonist 27 100.00 Very High Very High Very High
Enkephalin 20 100.00 Very High Very High Very High
nociceptor 10 100.00 Very High Very High Very High
Neurotransmitter 21 99.98 Very High Very High Very High
mu opioid receptor 1 99.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Vomiting 516 99.66 Very High Very High Very High
INFLAMMATION 88 99.64 Very High Very High Very High
Neurogenic Inflammation 14 99.56 Very High Very High Very High
Cancer 34 98.56 Very High Very High Very High
Pain 40 98.44 Very High Very High Very High
Nociception 12 98.32 Very High Very High Very High
Necrosis 4 98.32 Very High Very High Very High
Hypotension 2 98.24 Very High Very High Very High
Increased Venous Pressure Under Development 15 97.96 Very High Very High Very High
Anxiety Disorder 2 97.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Aprepitant is thought to prevent emesis by blocking the binding of substance P to NK1 receptors in the brain (Aguilar et al. 2005; Kris et al. 2005; Viale 2005).
substance P Binding (binding) of in brain associated with vomiting and substance p
1) Confidence 0.47 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012554 Disease Relevance 1.02 Pain Relevance 0.14
The effect of substance P can be dependent on its C-terminal moiety implicating by this way an interaction with specific neurokinin receptors or can be dependent on its N-terminal moiety which does not involve a specific membrane receptor.
neurokinin Binding (interaction) of associated with substance p
2) Confidence 0.47 Published 1990 Journal Pathol. Biol. Section Abstract Doc Link 1689813 Disease Relevance 0.43 Pain Relevance 0.56
IMPORTANCE OF THE FIELD: Substance P is involved in mediating a number of biological effects such as emesis, pain, inflammation, bronchoconstriction, antitumor activity, and regulation of gastrointestinal and CNS function by binding to the neurokinin-1 (NK1) receptor.
NK1 Binding (binding) of associated with pain, inflammation, antagonist, vomiting and substance p
3) Confidence 0.47 Published 2010 Journal Expert Opin Ther Pat Section Abstract Doc Link 20533894 Disease Relevance 0.29 Pain Relevance 0.28
Aprepitant is believed to prevent emesis by blocking the binding of substance P to NK1 receptors in the brain.
substance P Binding (binding) of in brain associated with vomiting and substance p
4) Confidence 0.47 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012554 Disease Relevance 0.92 Pain Relevance 0.18
Pharmacology of CP-99,994; a nonpeptide antagonist of the tachykinin neurokinin-1 receptor.

(+)-(2S,3S)-3-(2-methoxybenzylamino)-2-phenylpiperidine (CP-99,994) binds selectively and with high affinity (Ki = 0.25 nM) to neurokinin (NK)-1 tachykinin receptors in a human cell line and in guinea pigs where it acts as an antagonist as evidenced by its blockade of substance P-induced excitation of locus coeruleus neurons in vitro.

neurokinin Binding (binds) of in locus coeruleus associated with qutenza, locus ceruleus, antagonist and substance p
5) Confidence 0.36 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 7693914 Disease Relevance 0 Pain Relevance 0.59
The mammalian tachykinins include substance P, neurokinin A and neurokinin B, which exert their effects by binding to specific receptors.
neurokinin A Binding (binding) of associated with substance p
6) Confidence 0.36 Published 1996 Journal Int. J. Biochem. Cell Biol. Section Abstract Doc Link 8925404 Disease Relevance 0.06 Pain Relevance 0.24
Different binding epitopes on the NK1 receptor for substance P and non-peptide antagonist.
substance P Binding (binding) of associated with antagonist and substance p
7) Confidence 0.36 Published 1993 Journal Nature Section Title Doc Link 7681152 Disease Relevance 0.17 Pain Relevance 0.55
Thin nerve fibres, which from a morphological point of view were most probably sensory, showed immunoreactivity for substance P (SP), calcitonin gene-related peptide (CGRP), neuropeptide K (NPK) and neurokinin A (NKA).
neurokinin A Binding (immunoreactivity) of in nerve associated with neuropeptide, calcitonin gene-related peptide and substance p
8) Confidence 0.36 Published 1994 Journal Histochemistry Section Abstract Doc Link 7523335 Disease Relevance 0 Pain Relevance 0.43
The mammalian tachykinins include substance P, neurokinin A and neurokinin B, which exert their effects by binding to specific receptors.
substance P Binding (binding) of associated with substance p
9) Confidence 0.36 Published 1996 Journal Int. J. Biochem. Cell Biol. Section Abstract Doc Link 8925404 Disease Relevance 0.06 Pain Relevance 0.24
Heterodimerization of substance P and mu-opioid receptors regulates receptor trafficking and resensitization.
substance P Binding (Heterodimerization) of associated with mu opioid receptor and substance p
10) Confidence 0.36 Published 2003 Journal J. Biol. Chem. Section Title Doc Link 14532289 Disease Relevance 0.09 Pain Relevance 0.62
Partially purified nerve varicosities prepared from canine small intestinal myenteric, deep muscular and submucosal plexuses were found to contain, by radioimmunoassay, gastrin-releasing polypeptide (GRP), substance P, Leu-enkephalin, Met-enkephalin, vasoactive intestinal polypeptide (VIP) and neurokinin A, but did not contain detectable amounts of neurokinin B.
neurokinin A Binding (contain) of in nerve associated with enkephalin, increased venous pressure under development and substance p
11) Confidence 0.36 Published 1990 Journal Peptides Section Abstract Doc Link 2342994 Disease Relevance 0.17 Pain Relevance 0.44
Tachykinins represent a family of neuropeptides sharing similar C-terminus sequences, but exhibiting preferential binding to one of three receptors called neurokinin receptors (NK-R).
neurokinin Binding (binding) of associated with neuropeptide
12) Confidence 0.36 Published 2004 Journal Front. Biosci. Section Abstract Doc Link 15353350 Disease Relevance 0.17 Pain Relevance 0.31
The rat substance P antibody (mAb NC1/34 HL) recognizes a sequence common to substance P and neurokinins A and B (Cuello et al., 1979), but appears to be relatively selective for substance P and neurokinin A when used for immunocytochemistry in these conditions (McLeod et al., 2000; Polgár et al., 2006).
substance P Binding (recognizes) of associated with substance p
13) Confidence 0.36 Published 2007 Journal The European Journal of Neuroscience Section Body Doc Link PMC2635481 Disease Relevance 0 Pain Relevance 0.22
Our data show that NEP and NEP2, the most important enzymes involved in tachykinin metabolism, are expressed in human sperm at both mRNA and protein levels.
tachykinin Binding (metabolism) of in sperm
14) Confidence 0.35 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2936315 Disease Relevance 0.06 Pain Relevance 0.03
This regional pattern of distribution argues for a specific role for each tachykinin in the regulation of sperm function.
tachykinin Binding (role) of in sperm
15) Confidence 0.35 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2936315 Disease Relevance 0 Pain Relevance 0.05
Thin nerve fibres, which from a morphological point of view were most probably sensory, showed immunoreactivity for substance P (SP), calcitonin gene-related peptide (CGRP), neuropeptide K (NPK) and neurokinin A (NKA).
neuropeptide K Binding (immunoreactivity) of in nerve associated with neuropeptide, calcitonin gene-related peptide and substance p
16) Confidence 0.35 Published 1994 Journal Histochemistry Section Abstract Doc Link 7523335 Disease Relevance 0 Pain Relevance 0.43
Thin nerve fibres, which from a morphological point of view were most probably sensory, showed immunoreactivity for substance P (SP), calcitonin gene-related peptide (CGRP), neuropeptide K (NPK) and neurokinin A (NKA).
NPK Binding (immunoreactivity) of in nerve associated with neuropeptide, calcitonin gene-related peptide and substance p
17) Confidence 0.35 Published 1994 Journal Histochemistry Section Abstract Doc Link 7523335 Disease Relevance 0 Pain Relevance 0.43
Here we identify epitopes on the NK1 receptor responsible for the specific binding of CP 96345 by systematic exchange of corresponding segments between the NK1 receptor and the homologous NK3 (neurokinin B) receptor, which does not bind the non-peptide ligand.
neurokinin Neg (not) Binding (bind) of associated with substance p
18) Confidence 0.35 Published 1993 Journal Nature Section Abstract Doc Link 7681152 Disease Relevance 0.18 Pain Relevance 0.59
Human HK-1 also binds to the human NK2 and NK3 receptors, with an affinity about 200-250-fold lower than for NK1 receptors [4,10,13].
NK2 Binding (binds) of
19) Confidence 0.33 Published 2010 Journal Respir Res Section Body Doc Link PMC2959027 Disease Relevance 0.08 Pain Relevance 0.18
In vitro, the cyclopeptide S 16474 (cyclo-[Abo-Asp(D-Trp(Suc0Na)-Phe-N-(Me)Bzl)]) bound to both human tachykinin NK1 and NK2 receptors expressed in two lines of transfected Chinese hamster ovary cells (IC50 values 85 nM and 129 nM, respectively), while showing a poor affinity for the rat tachykinin NK1 receptor.
tachykinin NK1 Binding (bound) of in ovary
20) Confidence 0.32 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8750733 Disease Relevance 0.18 Pain Relevance 0.28

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