INT87939

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Context Info
Confidence 0.75
First Reported 2000
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 23
Total Number 24
Disease Relevance 6.15
Pain Relevance 6.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2RX3) transport (P2RX3) Golgi apparatus (P2RX3)
Anatomy Link Frequency
neurons 4
bladder 3
sensory neurons 2
tooth pulp 2
nerve 2
P2RX3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 61 100.00 Very High Very High Very High
qutenza 30 100.00 Very High Very High Very High
adenocard 8 100.00 Very High Very High Very High
Spinal cord 2 99.60 Very High Very High Very High
unmyelinated 2 99.04 Very High Very High Very High
Lasting pain 1 98.60 Very High Very High Very High
dorsal root ganglion 1 98.56 Very High Very High Very High
interstitial cystitis 9 98.16 Very High Very High Very High
Analgesic 4 97.96 Very High Very High Very High
intrathecal 1 97.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 27 99.84 Very High Very High Very High
Pain 52 99.26 Very High Very High Very High
Interstitial Cystitis 9 98.16 Very High Very High Very High
Ganglion Cysts 28 98.08 Very High Very High Very High
INFLAMMATION 22 97.70 Very High Very High Very High
Hypersensitivity 4 97.16 Very High Very High Very High
Hyperalgesia 9 97.00 Very High Very High Very High
Calculi 12 95.08 Very High Very High Very High
Migraine Disorders 6 84.56 Quite High
Necrosis 1 83.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was concluded that the reported analgesic effect of chloral hydrate may be due to the interruption of pain transmission in dorsal root ganglia expressing P2X3 receptors.
Gene_expression (expressing) of P2X3 in dorsal root ganglia associated with pain and analgesic
1) Confidence 0.75 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11108830 Disease Relevance 0.10 Pain Relevance 0.20
Intrathecal administration of oligonucleotides antisense against P2X3 receptors for seven days significantly reduced the expression of P2X3 receptors in the saphenous nerve and significantly reduced the mechanical hyperalgesia induced by carrageenan.
Gene_expression (expression) of P2X3 in saphenous nerve associated with hyperalgesia and intrathecal
2) Confidence 0.75 Published 2009 Journal Pain Section Abstract Doc Link 19081189 Disease Relevance 0.95 Pain Relevance 1.09
P2X3 receptors are expressed in capsaicin-sensitive small-sized dorsal root ganglion (DRG) neurons, and they are involved in the generation of rapidly desensitizing inward current and evoking nocifensive behavior and thermal hyperalgesia.
Gene_expression (expressed) of P2X3 in neurons associated with ganglion cysts, dorsal root ganglion, qutenza and thermal hyperalgesia
3) Confidence 0.75 Published 2000 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 11188502 Disease Relevance 0.43 Pain Relevance 0.70
There was a significant decrease in P2X3 immunoreactivity in responders to RTX, indicating a potential pathophysiological role for the P2X3 expressing fibres.


Gene_expression (expressing) of P2X3
4) Confidence 0.75 Published 2004 Journal Eur. Urol. Section Body Doc Link 15245821 Disease Relevance 0 Pain Relevance 0
Evidence is accumulating which supports a role for ATP in the initiation of pain by acting on P2X receptors, in particular P2X3, expressed on nociceptive afferent nerve terminals.
Gene_expression (expressed) of P2X3 in nerve associated with nociception and pain
5) Confidence 0.66 Published 2001 Journal J. Dent. Res. Section Abstract Doc Link 11332536 Disease Relevance 0.29 Pain Relevance 0.19
We conclude that P2X3 receptors are present on both myelinated and unmyelinated nerve fibers in human dental pulp and may play a role in dental pain mechanisms.
Gene_expression (present) of P2X3 in nerve associated with pain and unmyelinated
6) Confidence 0.65 Published 2001 Journal J. Dent. Res. Section Abstract Doc Link 11332536 Disease Relevance 0.31 Pain Relevance 0.29
The ATP-gated cation channel P2X3 is expressed selectively by rat sensory neurones, and may play a role in nociception by binding ATP released from damaged or inflamed tissues.
Gene_expression (expressed) of P2X3 associated with nociception
7) Confidence 0.65 Published 2000 Journal Neuroreport Section Abstract Doc Link 10790870 Disease Relevance 0.10 Pain Relevance 0
Co-localization studies showed < 15% overlap with the trkA immunostaining in DRG, indicating that P2X3 was expressed predominantly in sensory neurons that are also isolectin B4 positive.
Gene_expression (expressed) of P2X3 in sensory neurons
8) Confidence 0.65 Published 2000 Journal Neuroreport Section Abstract Doc Link 10790870 Disease Relevance 0.08 Pain Relevance 0.15
Recent studies indicate that acute, long-lasting sensitization of trigeminal nociceptive neurons occurs via distinct processes involving enhanced expression and function of adenosine triphosphate (ATP)-gated P2X3 receptors known to play a role in chronic pain.
Gene_expression (expression) of P2X3 in neurons associated with nociception, adenocard and lasting pain
9) Confidence 0.65 Published 2008 Journal Mol. Neurobiol. Section Abstract Doc Link 18459072 Disease Relevance 0.83 Pain Relevance 0.99
Membrane currents and changes in the intracellular Ca2+ concentration ([Ca2+]i) were measured in HEK293 cells transfected with the human P2X3 receptor (HEK293-hP2X3).
Gene_expression (transfected) of P2X3
10) Confidence 0.65 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12694404 Disease Relevance 0 Pain Relevance 0.12
Conclusion VR1 and P2X3 are present in the human urinary bladder and may contribute to distinct pathophysiological states of bladder overactivity, in accord with their differential expression in sensory neurones.
Gene_expression (present) of P2X3 in bladder
11) Confidence 0.60 Published 2001 Journal BJU Int. Section Abstract Doc Link 11412212 Disease Relevance 0.15 Pain Relevance 0.07
AIMS: To investigate the levels of the capsaicin or vanilloid receptor-1 (VR1) and the ATP-gated purinoceptor P2X3 in painful and nonpainful human tooth pulps.
Spec (investigate) Gene_expression (levels) of P2X3 in tooth pulps associated with pain and qutenza
12) Confidence 0.59 Published 2003 Journal J Orofac Pain Section Abstract Doc Link 14520770 Disease Relevance 0 Pain Relevance 0.35
CONCLUSION: The presence of VR1 and P2X3 in fibers of human tooth pulp suggest that they may play a role in perception of dental pain, but further studies, including quantitation of their ligands, are necessary to elucidate any role they may play in pathophysiologic states.


Gene_expression (presence) of P2X3 in tooth pulp
13) Confidence 0.59 Published 2003 Journal J Orofac Pain Section Body Doc Link 14520770 Disease Relevance 0 Pain Relevance 0
OBJECTIVES: The ATP-gated purinergic receptor P2X3 is expressed by small diameter sensory neurons and has been identified in normal and neurogenic human bladder suburothelial fibres.
Gene_expression (expressed) of P2X3 in bladder
14) Confidence 0.58 Published 2004 Journal Eur. Urol. Section Abstract Doc Link 15245821 Disease Relevance 0.28 Pain Relevance 0.13
Membrane currents in response to the application of alpha, beta-methylene ATP (alpha,beta-meATP) were recorded by the whole-cell patch-clamp technique in human embryonic kidney 293 cells transfected with the human P2X3 receptor (HEK 293-hP2X3 cells).
Gene_expression (transfected) of P2X3 receptor in embryonic kidney
15) Confidence 0.57 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11108830 Disease Relevance 0 Pain Relevance 0.16
There is evidence from the rat bladder that in certain pathological conditions, such as inflammation (interstitial cystitis), P2X3 receptors become sensitised and there is also a prominent increase in the number of P2X3 receptor-positive neurons in pelvic and lumbar splanchnic pathways, perhaps contributing to the hypersensitivity seen in pathophysiological conditions [22].
Gene_expression (neurons) of P2X3 receptor-positive in neurons associated with inflammation, hypersensitivity and interstitial cystitis
16) Confidence 0.55 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583211 Disease Relevance 0.67 Pain Relevance 0.44
The purpose of this study was to determine whether distension of the human ureter results in the release of ATP and whether the nociceptive P2 receptor, P2X3, is expressed on suburothelial sensory nerves in the human ureter.
Gene_expression (expressed) of P2X3 in ureter associated with nociception
17) Confidence 0.50 Published 2008 Journal Purinergic Signal Section Abstract Doc Link PMC2583211 Disease Relevance 0.36 Pain Relevance 0.25
ATP release from the human ureter on distension and P2X3 receptor expression on suburothelial sensory nerves

It is not clear how the increase in intraluminal pressure behind an obstructing ureteric calculus causes an increase in action potential frequency in ureteric sensory nerves so the pain messages are transmitted to the brain.

Gene_expression (expression) of P2X3 in sensory nerves associated with pain, action potential and calculi
18) Confidence 0.50 Published 2008 Journal Purinergic Signal Section Title Doc Link PMC2583211 Disease Relevance 0.35 Pain Relevance 0.25
Membrane currents and changes in the intracellular Ca2+ concentration ([Ca2+]i) were measured in HEK293 cells transfected with the human P2X3 receptor (HEK293-hP2X3).
Gene_expression (transfected) of P2X3 receptor
19) Confidence 0.33 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12694404 Disease Relevance 0 Pain Relevance 0.12
For example the trafficking of newly synthesised receptors regulates P2X3 receptor surface expression (Vacca et al. 2009) and recycling plays a role in epithelial sodium channel expression (Butterworth et al. 2005).
Gene_expression (expression) of P2X3 associated with sodium channel
20) Confidence 0.22 Published 2010 Journal Journal of Neurochemistry Section Body Doc Link PMC2878604 Disease Relevance 0 Pain Relevance 0.11

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