INT87941

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Context Info
Confidence 0.13
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 7.14
Pain Relevance 6.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (DRGX)
Anatomy Link Frequency
neurons 5
DRG 3
nociceptor 1
DRGX (Homo sapiens)
Pain Link Frequency Relevance Heat
dorsal root ganglion 165 100.00 Very High Very High Very High
bradykinin 107 100.00 Very High Very High Very High
nociceptor 2 100.00 Very High Very High Very High
GCH1 56 99.88 Very High Very High Very High
Potency 1 99.72 Very High Very High Very High
Sciatic nerve 121 99.60 Very High Very High Very High
qutenza 31 99.52 Very High Very High Very High
Action potential 10 98.48 Very High Very High Very High
Neuropathic pain 36 98.04 Very High Very High Very High
Arthritis 96 97.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 167 100.00 Very High Very High Very High
Targeted Disruption 28 98.96 Very High Very High Very High
Neuropathic Pain 62 98.04 Very High Very High Very High
Arthritis 108 97.20 Very High Very High Very High
Nervous System Injury 38 97.04 Very High Very High Very High
INFLAMMATION 190 96.12 Very High Very High Very High
Pain 131 92.60 High High
Nociception 55 86.76 High High
Injury 46 86.24 High High
Neurogenic Inflammation 16 86.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was a significant decrease in numbers of P2X3-like immunoreactive neurons in human DRG after central axotomy (to 36%), similar to the decrease in rat DRG after peripheral axotomy.
Negative_regulation (decrease) of DRG in neurons
1) Confidence 0.13 Published 2000 Journal Neuroreport Section Abstract Doc Link 10790870 Disease Relevance 0.08 Pain Relevance 0.18
There was a significant decrease in numbers of P2X3-like immunoreactive neurons in human DRG after central axotomy (to 36%), similar to the decrease in rat DRG after peripheral axotomy.
Negative_regulation (decrease) of DRG in neurons
2) Confidence 0.13 Published 2000 Journal Neuroreport Section Abstract Doc Link 10790870 Disease Relevance 0.07 Pain Relevance 0.20
A-887826 effectively suppressed evoked action potential firing when DRG neurons were held at depolarized potentials and reversibly suppressed spontaneous firing in small diameter DRG neurons from complete Freund's adjuvant inflamed rats.
Negative_regulation (suppressed) of DRG in DRG associated with dorsal root ganglion and action potential
3) Confidence 0.03 Published 2010 Journal Neuropharmacology Section Abstract Doc Link 20566409 Disease Relevance 0.92 Pain Relevance 0.90
However, in the contralateral DRG of the same animals the proportion of BK–gold-labelled neurons declined in the intermediate phase (day 10) and chronic phase (days 21–84) of AIA and was not significantly different from the control value.
Negative_regulation (declined) of DRG in neurons associated with dorsal root ganglion, bradykinin and arthritis
4) Confidence 0.03 Published 2000 Journal Arthritis Res Section Abstract Doc Link PMC17819 Disease Relevance 1.15 Pain Relevance 0.99
These mice also present a means to potentially rescue the developmental DRG nociceptor losses described in the galanin knockout and thus potentially allow, for the first time, the characterisation of a developmentally normal adult that is null for galanin.
Negative_regulation (losses) of DRG in nociceptor associated with targeted disruption and nociceptor
5) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2978139 Disease Relevance 0.82 Pain Relevance 0.38
Further analysis of NaV1.8 distribution revealed that immunoreactivity and mRNA levels were decreased and unaffected, respectively, in the ipsilateral L4 and L5 DRG; however sciatic nerve NaV1.8 mRNA showed nearly an 11-fold ipsilateral increase.
Neg (unaffected) Negative_regulation (decreased) of DRG in DRG associated with dorsal root ganglion and sciatic nerve
6) Confidence 0.01 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2667430 Disease Relevance 0.94 Pain Relevance 0.95
There was a significant decrease (F(2,35) = 17.95, P < 0.05) in the lumbar (L4-5) DRG for the TRPV1-IR/total cells ratio 1 month after perineural RTX application (250 ng), as compared to perineural vehicle application or naïve animals (Fig. 6).


Negative_regulation (decrease) of DRG
7) Confidence 0.01 Published 2008 Journal Mol Pain Section Body Doc Link PMC2242785 Disease Relevance 0.17 Pain Relevance 0.35
Additionally, this group found that perineural capsaicin application produced a reduction in the proportion of small-sized neurons in the ipsilateral DRG.
Negative_regulation (reduction) of DRG in neurons associated with qutenza
8) Confidence 0.01 Published 2008 Journal Mol Pain Section Body Doc Link PMC2242785 Disease Relevance 0.65 Pain Relevance 0.73
The present study provides clear evidence of the therapeutic potency of GCH1 down-regulation in DRG via rAAV-shGCH1-mediated silencing for treating neuropathic pain.
Negative_regulation (regulation) of DRG associated with dorsal root ganglion, neuropathic pain, gch1 and potency
9) Confidence 0.01 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785765 Disease Relevance 1.17 Pain Relevance 1.29
inhibitor in DRG neurons [21].
Negative_regulation (inhibitor) of DRG in neurons associated with dorsal root ganglion
10) Confidence 0.01 Published 2009 Journal Mol Pain Section Body Doc Link PMC2650694 Disease Relevance 0.58 Pain Relevance 0.35
Dendrotoxin K (DTX(K)), a specific inhibitor of Kv1.1, reduced the DRG K(+) current at +20 mV by 34%, consistent with an important contribution of channels incorporating the Kv1.1 subunit to the delayed rectifier current.
Negative_regulation (inhibitor) of DRG K in DRG associated with dorsal root ganglion
11) Confidence 0.00 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12538804 Disease Relevance 0.59 Pain Relevance 0.41

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