INT88020

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Context Info
Confidence 0.70
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 32
Total Number 32
Disease Relevance 19.78
Pain Relevance 9.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fas) aging (Fas) extracellular region (Fas)
plasma membrane (Fas) nucleus (Fas) cytoplasm (Fas)
Anatomy Link Frequency
T cells 4
brain 2
epithelium 2
cerebral cortex 2
liver 1
Fas (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 39 99.80 Very High Very High Very High
Morphine 37 99.76 Very High Very High Very High
cerebral cortex 69 99.68 Very High Very High Very High
withdrawal 38 99.58 Very High Very High Very High
Opioid 8 99.30 Very High Very High Very High
opiate 34 99.14 Very High Very High Very High
opioid receptor 6 98.96 Very High Very High Very High
Paracetamol 1 98.20 Very High Very High Very High
Multiple sclerosis 7 96.64 Very High Very High Very High
Inflammation 36 96.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 914 100.00 Very High Very High Very High
Opiate Addiction 28 99.58 Very High Very High Very High
Lymphoproliferative Disease 2 99.36 Very High Very High Very High
Acute Liver Failure 3 99.28 Very High Very High Very High
Necrosis 13 98.56 Very High Very High Very High
Death 269 98.40 Very High Very High Very High
Obesity 93 98.40 Very High Very High Very High
Cancer 44 98.36 Very High Very High Very High
Suicidal Behaviour 189 98.04 Very High Very High Very High
Overdose 1 97.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic (5 days) heroin (5-30 mg/kg) and morphine (10-100 mg/kg) were also associated with increased native Fas (76% and 45%) and with different expressions of glycosylated Fas.
Positive_regulation (increased) of Fas associated with morphine
1) Confidence 0.70 Published 2003 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 14530904 Disease Relevance 0.30 Pain Relevance 1.08
In heroin-dependent rats, opiate withdrawal (48 h) resulted in a sustained increase in native Fas (107%) and in up-regulation of 51 kDa glycosylated Fas (51%).
Positive_regulation (increase) of Fas associated with opiate and withdrawal
2) Confidence 0.70 Published 2003 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 14530904 Disease Relevance 0.28 Pain Relevance 1.18
The main results indicate that chronic heroin/morphine treatment and heroin withdrawal are associated with up-regulation of 35 kDa native Fas (and with different expressions of glycosylated Fas), and also with concomitant increases of dynamin in rat brain.
Positive_regulation (up-regulation) of Fas in brain associated with opiate addiction, withdrawal and morphine
3) Confidence 0.70 Published 2003 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 14530904 Disease Relevance 0.27 Pain Relevance 1.22
Chronic (10-100 mg/kg for 5 days), but not acute (30 mg/kg for 2 h), treatment with morphine (a micro-opioid peptide receptor agonist) induced up-regulation of Fas aggregates in the brain (approximately 110/120 kDa: 39%, and approximately 203 kDa: 89%).
Positive_regulation (up-regulation) of Fas in brain associated with agonist, opioid and morphine
4) Confidence 0.69 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15288576 Disease Relevance 0.06 Pain Relevance 0.64
Acute (2 h) treatments with the micro-opioid receptor agonists heroin (10 mg/kg) and morphine (30 mg/kg) increased the immunodensity of native Fas (124% and 36%) but not that of glycosylated Fas in the cerebral cortex.
Positive_regulation (increased) of Fas in cerebral cortex associated with agonist, opioid receptor, cerebral cortex and morphine
5) Confidence 0.50 Published 2003 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 14530904 Disease Relevance 0.33 Pain Relevance 0.94
Acute (2 h) treatments with the micro-opioid receptor agonists heroin (10 mg/kg) and morphine (30 mg/kg) increased the immunodensity of native Fas (124% and 36%) but not that of glycosylated Fas in the cerebral cortex.
Positive_regulation (increased) of Fas in cerebral cortex associated with agonist, opioid receptor, cerebral cortex and morphine
6) Confidence 0.50 Published 2003 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 14530904 Disease Relevance 0.33 Pain Relevance 1.03
Enzymatic N-deglycosylation of Fas receptor increased the content of Fas aggregates (approximately 110/120 kDa: five- to sixfold, and approximately 203 kDa: two- to threefold), suggesting that Fas glycosylation is involved in regulating receptor dimerization.
Positive_regulation (increased) of Fas
7) Confidence 0.50 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15288576 Disease Relevance 0.07 Pain Relevance 0.49
In analogy with other immune-protected sites, participation of the apoptosis-inducing Fas/FasL molecules could play an important role.
Positive_regulation (apoptosis-inducing) of Fas associated with apoptosis
8) Confidence 0.46 Published 2000 Journal Glia Section Abstract Doc Link 10797617 Disease Relevance 0.63 Pain Relevance 0.09
In heroin-dependent rats, opiate withdrawal (48 h) resulted in a sustained increase in native Fas (107%) and in up-regulation of 51 kDa glycosylated Fas (51%).
Positive_regulation (up-regulation) of Fas associated with opiate and withdrawal
9) Confidence 0.44 Published 2003 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 14530904 Disease Relevance 0.33 Pain Relevance 1.27
Preincubation of rat cortical membranes with N-ethylmaleimide (NEM; 1 mM for 1 h at 37 degrees C) reduced the immunodensity of approximately 203 kDa Fas aggregates (51%) and increased that of 35 kDa native Fas (172%) and 51/48 kDa glycosylated Fas (47%), indicating that disulfide bonds are involved in Fas dimerization.
Positive_regulation (increased) of Fas
10) Confidence 0.44 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15288576 Disease Relevance 0.08 Pain Relevance 0.35
Preincubation of rat cortical membranes with N-ethylmaleimide (NEM; 1 mM for 1 h at 37 degrees C) reduced the immunodensity of approximately 203 kDa Fas aggregates (51%) and increased that of 35 kDa native Fas (172%) and 51/48 kDa glycosylated Fas (47%), indicating that disulfide bonds are involved in Fas dimerization.
Positive_regulation (increased) of Fas
11) Confidence 0.44 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15288576 Disease Relevance 0.08 Pain Relevance 0.36
In the following experiments, we set out to identify cell biological processes that predict cell-surface expression of Fas, and to identify consequences of Fas activation.
Positive_regulation (activation) of Fas
12) Confidence 0.40 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.54 Pain Relevance 0.12
OA caused a 1.4-fold induction of FAS mRNA (P < 0.05), and a 2.0-fold induction of G6PDH (P < 0.05).
Positive_regulation (induction) of FAS mRNA
13) Confidence 0.39 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2846940 Disease Relevance 0.51 Pain Relevance 0
In addition, the activities of ME and G6PDH, which provide NADPH required for FAS, were accelerated by OA administration.
Positive_regulation (required) of FAS
14) Confidence 0.34 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2846940 Disease Relevance 1.14 Pain Relevance 0
Since activated T cells express elevated level of Fas, we then determined the cytotoxicity of KC against alloreactive T cells (ATC).
Positive_regulation (elevated) of Fas in T cells
15) Confidence 0.32 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2410251 Disease Relevance 0.05 Pain Relevance 0
Furthermore, there was an increase in Fas-mediated, IL-2 independent, apoptosis (AICD) in the T cells from the thermally injured rats.
Positive_regulation (increase) of Fas in T cells associated with apoptosis and death
16) Confidence 0.27 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1989035 Disease Relevance 1.46 Pain Relevance 0.04
Our data therefore indicate that while Fas activation does not induce or suppress cell cycle [9], the highest expression of Fas is associated with progression past the S-phase of cell cycle or recent exit from cell cycle.


Positive_regulation (activation) of Fas
17) Confidence 0.27 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.28 Pain Relevance 0
We previously reported that Fas activation leads to unscheduled DNA synthesis, the activation of NF-?
Positive_regulation (activation) of Fas
18) Confidence 0.27 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 1.61 Pain Relevance 0.14
Since estrogen induces neuroblasts to enter S-phase of cell cycle, while suppressing the cell-surface expression of Fas, we decided to examine the extent to which estrogen regulates cell cycle proteins concurrent with Fas activation.
Positive_regulation (activation) of Fas in neuroblasts
19) Confidence 0.27 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.29 Pain Relevance 0
and (2): 'what are the consequences of Fas activation for some of these processes?'
Positive_regulation (activation) of Fas
20) Confidence 0.27 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.38 Pain Relevance 0

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