INT881

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Context Info
Confidence 0.58
First Reported 1975
Last Reported 2009
Negated 3
Speculated 5
Reported most in Abstract
Documents 164
Total Number 169
Disease Relevance 15.10
Pain Relevance 75.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gh1) signal transduction (Gh1) mitochondrion (Gh1)
extracellular space (Gh1) extracellular region (Gh1) plasma membrane (Gh1)
Anatomy Link Frequency
pituitary 30
Thyroid 8
hypothalamus 7
tail 6
plasma 4
Gh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 711 100.00 Very High Very High Very High
substance P 260 100.00 Very High Very High Very High
Clonidine 247 100.00 Very High Very High Very High
Morphine 94 100.00 Very High Very High Very High
adenocard 50 100.00 Very High Very High Very High
opiate 46 100.00 Very High Very High Very High
depression 35 100.00 Very High Very High Very High
fluoxetine 32 100.00 Very High Very High Very High
MU agonist 21 100.00 Very High Very High Very High
methadone 16 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 37 100.00 Very High Very High Very High
Stress 776 99.98 Very High Very High Very High
Cancer 410 99.80 Very High Very High Very High
Aging 39 99.62 Very High Very High Very High
Hypoglycemia 17 99.52 Very High Very High Very High
Obesity 150 99.32 Very High Very High Very High
Body Weight 44 99.28 Very High Very High Very High
Bordatella Infection 21 98.96 Very High Very High Very High
Congenital Anomalies 6 98.24 Very High Very High Very High
Reactive Attachment Disorder 8 98.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ten hr prior to the microinjection, alpha-methyl-p-tyrosine (250 mg/kg body weight) was intraperitoneally injected to prevent spontaneous pulsatile GH release.
Negative_regulation (prevent) of Localization (release) of GH in body associated with body weight
1) Confidence 0.58 Published 1983 Journal Endocrinol. Jpn. Section Abstract Doc Link 6141046 Disease Relevance 0.10 Pain Relevance 0.39
Reserpine (10 mg/kg i.p.) caused a complete suppression of the normal, pulsatile secretion of GH in all animals.
Negative_regulation (suppression) of Localization (secretion) of GH
2) Confidence 0.58 Published 1981 Journal Neuroendocrinology Section Abstract Doc Link 6114446 Disease Relevance 0 Pain Relevance 0.24
In addition they suggest that impairment of GH secretion in thyroidectomized rats does not depend upon changes in the hypothalamic SRIF regulation of the hormone but could be dependent on a defect in GRF release and/or, most probably, GH synthesis directly at the pituitary level.
Negative_regulation (impairment) of Localization (secretion) of GH in pituitary associated with somatostatin
3) Confidence 0.58 Published 1985 Journal Neuroendocrinology Section Abstract Doc Link 2867482 Disease Relevance 0.05 Pain Relevance 0.38
Thyroid deprivation induced a 92-fold decrease in GH release from the pituitary; however, the ratio between GH release and GH content was similar in TPTX and normal rats, and human pancreatic growth hormone-releasing factor (GRF) (3 X 10(-8) M) was still able to stimulate residual GH release by hemipituitaries from TPTX rats in a manner similar to that in euthyroid controls (295 and 254% stimulation, respectively).
Negative_regulation (decrease) of Localization (release) of GH in Thyroid
4) Confidence 0.58 Published 1985 Journal Neuroendocrinology Section Abstract Doc Link 2867482 Disease Relevance 0.08 Pain Relevance 0.41
The mu-agonist morphine and the kappa agonist U50,488 caused a stimulation and inhibition of GH secretion, respectively, on postnatal day 10.
Negative_regulation (inhibition) of Localization (secretion) of GH associated with agonist and morphine
5) Confidence 0.58 Published 1996 Journal Neuroendocrinology Section Abstract Doc Link 8793890 Disease Relevance 0 Pain Relevance 0.63
The amount of GH secreted during a 6-h period as measured by planimetry was significantly reduced.
Negative_regulation (reduced) of Localization (secreted) of GH
6) Confidence 0.58 Published 1991 Journal Acta Endocrinol. Section Abstract Doc Link 1676866 Disease Relevance 0.14 Pain Relevance 0.12
Reserpine (1 mg/kg s.c.) abolished methadone-induced GH release in neonatal rats.
Negative_regulation (abolished) of Localization (release) of GH associated with methadone
7) Confidence 0.57 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3007734 Disease Relevance 0 Pain Relevance 0.78
In 30-day-old rats, pretreatment with yohimbine (2.5 mg/kg i.p.), but not prazosin (2.5 mg/kg s.c.) blocked opiate-induced GH release.
Negative_regulation (blocked) of Localization (release) of GH associated with opiate
8) Confidence 0.57 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3007734 Disease Relevance 0 Pain Relevance 0.98
Both treatments blocked methadone-induced GH release in neonatal rats.
Negative_regulation (blocked) of Localization (release) of GH associated with methadone
9) Confidence 0.57 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3007734 Disease Relevance 0 Pain Relevance 0.97
Haloperidol (1 mg/kg s.c.) but not cyproheptadine (5 mg/kg i.p.) attenuated methadone-stimulated GH release.
Negative_regulation (attenuated) of Localization (release) of GH associated with methadone
10) Confidence 0.57 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3007734 Disease Relevance 0 Pain Relevance 0.90
The inhibition of 5-HT synthesis by p-chlorophenylalanine also suppressed the secretory episode of GH seen in the morning and the release of GH induced by hypoglycaemia; both being partly restored in animals pretreated with 5-hydroxytryptamine.
Negative_regulation (suppressed) of Localization (release) of GH associated with hypoglycemia
11) Confidence 0.57 Published 1980 Journal J. Endocrinol. Section Abstract Doc Link 7430898 Disease Relevance 0.19 Pain Relevance 0.53
Higher doses (3 and 5 mg/kg) of CH-38083 only partly inhibited GH secretion induced by morphine.
Negative_regulation (inhibited) of Localization (secretion) of GH associated with morphine
12) Confidence 0.56 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1678497 Disease Relevance 0 Pain Relevance 1.40
The replacement of testosterone (10 mg/kg for 4 days) in castrates restored the effect of clonidine, whereas it decreased the stimulatory action of morphine on the GH secretion.
Negative_regulation (decreased) of Localization (secretion) of GH associated with morphine and clonidine
13) Confidence 0.56 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1678497 Disease Relevance 0 Pain Relevance 1.47
Phentolamine, given intravenously, inhibited the clonidine-induced GH release in a dose-dependnet manner.
Negative_regulation (inhibited) of Localization (release) of GH associated with clonidine
14) Confidence 0.56 Published 1978 Journal Horm. Res. Section Abstract Doc Link 669571 Disease Relevance 0 Pain Relevance 0.44
TTX or Na(+)-free medium slightly decreased the basal release of GH but did not markedly modify hGRF-stimulated GH release.
Negative_regulation (decreased) of Localization (release) of GH
15) Confidence 0.56 Published 1990 Journal Life Sci. Section Abstract Doc Link 2157930 Disease Relevance 0 Pain Relevance 0.45
Furthermore pimozide did not attenuate the inhibition of clonidine-induced GH secretion seen after apomorphine administration, however, it completely reversed apomorphine-induced PRL inhibition.
Negative_regulation (inhibition) of Localization (secretion) of GH associated with clonidine
16) Confidence 0.56 Published 1978 Journal Horm. Res. Section Abstract Doc Link 669571 Disease Relevance 0 Pain Relevance 0.44
L-Dopa administered intravenously and apomorphine administered intravenously or intraventricularly did not affect basal secretion of GH bu- produced a dose-dependnet inhibition of clonidine-induced GH release.
Negative_regulation (inhibition) of Localization (release) of GH associated with clonidine
17) Confidence 0.56 Published 1978 Journal Horm. Res. Section Abstract Doc Link 669571 Disease Relevance 0 Pain Relevance 0.45
The injection of yohimbine (3 mg/kg, i.p.) strongly inhibited the secretion of GH induced by clonidine treatment in sham-operated animals, and its inhibitory action was significantly attenuated in castrates.
Negative_regulation (inhibited) of Localization (secretion) of GH associated with clonidine
18) Confidence 0.56 Published 1990 Journal Neuroendocrinology Section Abstract Doc Link 2154719 Disease Relevance 0.41 Pain Relevance 0.77
However, even when the stimulation site was outside the CG, hGRF-induced GH secretion was suppressed.
Negative_regulation (suppressed) of Localization (secretion) of GH
19) Confidence 0.56 Published 1988 Journal Endocrinology Section Abstract Doc Link 3123202 Disease Relevance 0 Pain Relevance 0.40
To investigate the neural mechanism involved in suppression of GH secretion, we examined the effect of electrical stimulation of the midbrain central gray (CG) and several raphe nuclei on human (h) GRF-induced GH secretion in pentobarbital-anesthetized rats.
Negative_regulation (suppression) of Localization (secretion) of GH in midbrain associated with midbrain and raphe
20) Confidence 0.56 Published 1988 Journal Endocrinology Section Abstract Doc Link 3123202 Disease Relevance 0 Pain Relevance 0.31

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