INT88121

Context Info Confidence 0.22 First Reported 2000 Last Reported 2005 Negated 2 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 0.92 Pain Relevance 0.34

cytosol (Gsr) mitochondrion (Gsr) oxidoreductase activity (Gsr) cytoplasm (Gsr)

Anatomy Link Frequency erythrocytes 1 Gsr (Rattus norvegicus)

Pain Link Frequency Relevance Heat dexamethasone 3 98.00 corticosteroid 4 75.00 cINOD 4 65.24 aspirin 2 50.00 cytokine 1 40.20 Inflammation 2 39.80

Disease Link Frequency Relevance Heat Toxicity 3 98.22 Cancer 4 96.96 Necrosis 4 96.72 INFLAMMATION 5 65.00 Injury 2 63.96 Adhesions 1 42.84 Enteropathy 1 35.44 Ulcers 1 5.00 Stress 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Despite inhibiting cyclooxygenase activity, the attenuation of (S)-(+)-ketoprofen-induced intestinal toxicity could be correlated with a reduced oxidative damage characterized not only by a lack of changes in glutathione reductase activity and glutathione levels but also by an absence of up-regulation of tumor necrosis factor-alpha production in intestinal mucosa.

Regulation (changes) of glutathione reductase associated with necrosis, toxicity and cancer

1) Confidence 0.22 Published 2002 Journal Dig. Dis. Sci. Section Abstract Doc Link 11991627 Disease Relevance 0.80 Pain Relevance 0

G6PD and catalase (CAT) activities were found significantly lower than in the control, whereas glutathione peroxidase (GP) activity was significantly increased in the erythrocytes of rats the receiving drug; glutathione reductase (GR) activity was unaffected.

Neg (unaffected) Regulation (unaffected) of glutathione reductase in erythrocytes

2) Confidence 0.13 Published 2005 Journal J Enzyme Inhib Med Chem Section Abstract Doc Link 15895680 Disease Relevance 0.07 Pain Relevance 0.34

Aspirin did not affect cellular glutathione content or activity of glutathione peroxidase, glutathione reductase or endogenous catalase.

Neg (not) Regulation (affect) of glutathione reductase

3) Confidence 0.06 Published 2000 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 10807398 Disease Relevance 0.06 Pain Relevance 0

General Comments

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