INT88170

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Context Info
Confidence 0.69
First Reported 2000
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 2.00
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear chromosome (HMGA2) protein binding transcription factor activity (HMGA2) DNA binding (HMGA2)
mitosis (HMGA2) nucleus (HMGA2) nucleic acid binding transcription factor activity (HMGA2)
HMGA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 4 99.64 Very High Very High Very High
Chronic pancreatitis 2 80.48 Quite High
Disease Link Frequency Relevance Heat
Adenocarcinoma 2 99.40 Very High Very High Very High
Carcinoma 6 98.96 Very High Very High Very High
Cancer 8 98.44 Very High Very High Very High
Adenoma 4 98.20 Very High Very High Very High
Malignant Neoplastic Disease 2 98.20 Very High Very High Very High
Pancreatic Cancer 6 91.60 High High
Glioma 2 88.12 High High
Serous Cystadenoma 2 84.64 Quite High
Pancreatitis 2 80.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, an increased expression level of the HMGI(Y) proteins was clearly associated with the malignant phenotype in pancreatic tissue.
Positive_regulation (increased) of HMGI associated with malignant neoplastic disease
1) Confidence 0.69 Published 2000 Journal Cancer Res. Section Abstract Doc Link 10866296 Disease Relevance 1.26 Pain Relevance 0.08
Abe et al, Cancer Res., 59: 1169-1174, 1999), we demonstrated that the expression level of the HMGI(Y) gene/proteins was significantly increased in colorectal adenocarcinoma and colorectal adenoma with severe cellular atypia.
Positive_regulation (increased) of HMGI associated with adenoma, adenocarcinoma and cancer
2) Confidence 0.69 Published 2000 Journal Cancer Res. Section Abstract Doc Link 10866296 Disease Relevance 0.58 Pain Relevance 0.05
Treatment with morphine lowered the [32P]-incorporation in HMG I and HMGI-C proteins and the level of the HMG I/Y transcript.
Positive_regulation (-incorporation) of HMGI-C associated with morphine
3) Confidence 0.49 Published 2000 Journal Life Sci. Section Abstract Doc Link 10809169 Disease Relevance 0.16 Pain Relevance 0.35

General Comments

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