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Context Info
Confidence 0.66
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.07
Pain Relevance 2.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Drd4) plasma membrane (Drd4) cytoplasm (Drd4)
signal transducer activity (Drd4)
Anatomy Link Frequency
striatum 1
hippocampus region 1
hippocampus 1
Drd4 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 185 100.00 Very High Very High Very High
dopamine receptor 23 100.00 Very High Very High Very High
Opioid 3 99.74 Very High Very High Very High
Hippocampus 6 99.68 Very High Very High Very High
Cannabinoid receptor 2 98.96 Very High Very High Very High
Migraine 4 98.88 Very High Very High Very High
Enkephalin 7 98.46 Very High Very High Very High
alcohol 1 95.20 Very High Very High Very High
projection neuron 3 89.12 High High
Glutamate 25 88.60 High High
Disease Link Frequency Relevance Heat
Headache 4 98.88 Very High Very High Very High
Targeted Disruption 15 98.70 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 20 93.96 High High
Psychosis 3 92.24 High High
Sprains And Strains 10 79.08 Quite High
Affective Disorder 1 76.04 Quite High
Hypersensitivity 7 63.76 Quite High
Congenital Anomalies 2 59.28 Quite High
Pain 5 34.72 Quite Low
Nervous System Malformation 1 29.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bronikowski and colleagues (2004) investigated gene expression changes in the
    hippocampus region of the brain and found that mice selectively bred for high wheel running had
    a 20% increase in D2 and D4 receptor expression (D1-like receptors were not analyzed in this
    study) compared to control line mice 16. 
Gene_expression (expression) of D4 receptor in hippocampus region associated with hippocampus
1) Confidence 0.66 Published 2010 Journal International Journal of Biological Sciences Section Body Doc Link PMC2836544 Disease Relevance 0.15 Pain Relevance 0.18
CB1 knockout mice display significant changes in striatal opioid peptide and D4 dopamine receptor gene expression.
Gene_expression (expression) of D4 dopamine receptor gene associated with targeted disruption, dopamine receptor, enkephalin and opioid
2) Confidence 0.52 Published 2006 Journal Brain Res. Section Title Doc Link 16684513 Disease Relevance 0.18 Pain Relevance 0.56
MK-801 also increases the extracellular dopamine level and regulates the dopamine D1, D2, D3, and D4 receptor gene expression in the hippocampus in a complex manner [19].
Gene_expression (expression) of D4 receptor gene in hippocampus associated with dopamine and hippocampus
3) Confidence 0.08 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC2832782 Disease Relevance 0.40 Pain Relevance 0.73
The other DA receptors are less abundant in the striatum: the D3 receptor is mostly expressed in the ventral striatum (Diaz et al., 1995), the D5 receptor expression is low and widespread (Rivera et al., 2002), and the D4 receptor expression is not detected (NoaĆ­n et al., 2006).
Gene_expression (expression) of D4 receptor in striatum associated with dopamine
4) Confidence 0.05 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0 Pain Relevance 0.50
As peripheral blood lymphocytes (PBL) may represent a tool for peripheral detection of neuroreceptors, we compared the expression of dopamine D3 (DRD3) and D4 (DRD4) receptors on PBL in migraine patients and in healthy controls using radioligand binding assay techniques in the presence of antidopamine D2-like receptor antibodies.
Gene_expression (expression) of D4 in PBL associated with dopamine and migraine
5) Confidence 0.02 Published 2000 Journal Cephalalgia Section Abstract Doc Link 10817442 Disease Relevance 0.33 Pain Relevance 0.55

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