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Context Info
Confidence 0.47
First Reported 1991
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 36
Total Number 46
Disease Relevance 28.37
Pain Relevance 23.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SFTPA1) extracellular region (SFTPA1)
Anatomy Link Frequency
tears 5
plasma 2
dorsal root 2
nasal 2
tooth 2
SFTPA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 699 100.00 Very High Very High Very High
Inflammation 402 100.00 Very High Very High Very High
Neuropeptide 307 100.00 Very High Very High Very High
rheumatoid arthritis 247 100.00 Very High Very High Very High
spinal inflammation 135 100.00 Very High Very High Very High
Neurotransmitter 106 100.00 Very High Very High Very High
calcitonin gene related peptide 64 100.00 Very High Very High Very High
Somatostatin 20 100.00 Very High Very High Very High
Calcitonin gene-related peptide 12 100.00 Very High Very High Very High
metalloproteinase 50 99.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypersensitivity 467 100.00 Very High Very High Very High
INFLAMMATION 434 100.00 Very High Very High Very High
Rheumatoid Arthritis 248 100.00 Very High Very High Very High
Low Back Pain 158 100.00 Very High Very High Very High
Nociception 9 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 141 99.82 Very High Very High Very High
Conjunctiva Disease 110 99.80 Very High Very High Very High
Pruritus 235 99.68 Very High Very High Very High
Endometriosis (extended) 1 99.46 Very High Very High Very High
Rhinitis 261 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Evidence suggests that the pathology of SpA is mediated by immune cells.
Positive_regulation (mediated) of SpA in immune cells
1) Confidence 0.47 Published 2008 Journal Semin. Arthritis Rheum. Section Body Doc Link 18166219 Disease Relevance 0.08 Pain Relevance 0
For instance, SP has been reported to be prolonged in patients with lesions of the premotor cortex, lesions of the parietal and temporal lobe, and lesions of the internal capsule and thalamus [40].
Positive_regulation (prolonged) of SP in cortex associated with thalamus
2) Confidence 0.35 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1513595 Disease Relevance 0.24 Pain Relevance 0.09
The infliximab dosage was increased in 21 out of 45 (46.7%) RA patients and in three of 10 (30%) SpA patients who developed infusion reactions.
Positive_regulation (increased) of SpA associated with infliximab and rheumatoid arthritis
3) Confidence 0.31 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779374 Disease Relevance 0.78 Pain Relevance 0.60
In our study, concomitant treatment with methotrexate was used to a lesser extent in patients with SpA than in patients with RA, probably because methotrexate is not a prerequisite therapy in SpA patients.
Neg (not) Positive_regulation (therapy) of SpA associated with rheumatoid arthritis and methotrexate
4) Confidence 0.31 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779374 Disease Relevance 0.46 Pain Relevance 0.69
Synovial levels of matrix metalloproteinase-3 (MMP-3) and tissue inhibitors of matrix metalloproteinases (TIMP) are also elevated in SpA synovium and treatment with infliximab rapidly downregulates synovial expression of MMP-3 and TIMP and serum MMP-3 (Vandooren et al 2004).
Positive_regulation (elevated) of SpA in synovium associated with infliximab and metalloproteinase
5) Confidence 0.31 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721298 Disease Relevance 0.14 Pain Relevance 0.52
The infliximab dosage was increased more than once in six RA and two SpA patients.
Positive_regulation (increased) of SpA associated with infliximab and rheumatoid arthritis
6) Confidence 0.29 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779374 Disease Relevance 0.69 Pain Relevance 0.51
In contrast, no release of SP could be recorded in response to DCS in the decerebrated preparation, although peripheral nociceptive stimulation (pinch) and noxious electric dorsal root stimulation induced an elevation of the SP levels.
Positive_regulation (elevation) of SP in dorsal root associated with nociception and substance p
7) Confidence 0.24 Published 1992 Journal Neurosurgery Section Abstract Doc Link 1381066 Disease Relevance 0.15 Pain Relevance 0.84
In contrast, no release of SP could be recorded in response to DCS in the decerebrated preparation, although peripheral nociceptive stimulation (pinch) and noxious electric dorsal root stimulation induced an elevation of the SP levels.
Positive_regulation (induced) of SP in dorsal root associated with nociception and substance p
8) Confidence 0.24 Published 1992 Journal Neurosurgery Section Abstract Doc Link 1381066 Disease Relevance 0.15 Pain Relevance 0.84
In agreement with previous studies [16,19], the increase in the CD163+ macrophage subset in SpA was not parallalled by changes in the global number of macrophages, as detected by the panmacrophage marker CD68.
Positive_regulation (increase) of SpA in macrophage
9) Confidence 0.22 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174942 Disease Relevance 0.48 Pain Relevance 0.24
The neuropeptide substance P (SP) is found within a subpopulation of nociceptive afferent nerve fibres and has been shown to be upregulated in a variety of sites following peripheral inflammation.
Positive_regulation (upregulated) of SP in nerve associated with nociception, inflammation, neuropeptide and substance p
10) Confidence 0.21 Published 2000 Journal Eur. J. Oral Sci. Section Abstract Doc Link 11153921 Disease Relevance 0.52 Pain Relevance 0.58
Our studies indicate that SP-induced cellular Ca+2 signals led to the activation of the NF-kappaB pathway, resulting in nuclear translocation of p65/p50 heterodimers that bind to high-affinity tandem kappaB sites on the VCAM-1 promoter, whereas SP activation induced NF-AT activation and ICAM-1 DNA binding.
Positive_regulation (activation) of SP associated with substance p
11) Confidence 0.21 Published 2000 Journal J. Investig. Dermatol. Symp. Proc. Section Abstract Doc Link 11147679 Disease Relevance 0.26 Pain Relevance 0.50
Both dentitions showed significant increases in CGRP, SP, VIP and NPY expression with caries progression.
Positive_regulation (increases) of SP in dentitions associated with substance p and calcitonin gene-related peptide
12) Confidence 0.19 Published 2002 Journal Arch. Oral Biol. Section Abstract Doc Link 12015218 Disease Relevance 0 Pain Relevance 0.81
However, using a “paired Wilcoxon Rank test” for statistical analysis –which analyses the magnitude of the difference in paired samples– allowed us to convincingly demonstrate the increase of SP, CGRP and VIP tear levels after CPT only in eyes challenged with allergen.
Positive_regulation (increase) of SP in eyes associated with substance p
13) Confidence 0.17 Published 2011 Journal Molecular Vision Section Body Doc Link PMC3021574 Disease Relevance 0.86 Pain Relevance 0.32
Our findings are in line with evidence demonstrating an increase of SP, CGRP, and VIP after nasal allergen challenge and in airway hyperresponsiveness [16,31,32].
Positive_regulation (increase) of SP in nasal associated with substance p
14) Confidence 0.17 Published 2011 Journal Molecular Vision Section Body Doc Link PMC3021574 Disease Relevance 1.17 Pain Relevance 0.24
Our results show a significant increase of SP, CGRP, and VIP tear levels after challenge with allergen –but not with diluent– and no significant changes at baseline and after challenge between CPT eyes and control eyes.
Positive_regulation (increase) of SP in eyes associated with substance p
15) Confidence 0.17 Published 2011 Journal Molecular Vision Section Body Doc Link PMC3021574 Disease Relevance 0.71 Pain Relevance 0.36
Most importantly, analysis of the joints from peptide no. 67-immunized mice induced typical histological signs of SpA.
Positive_regulation (induced) of SpA in joints
16) Confidence 0.16 Published 2004 Journal J. Immunol. Section Abstract Doc Link 15470026 Disease Relevance 0.51 Pain Relevance 0.17
Specifically, an increase of SP tear and plasma levels has been described in patients with VKC [24] and increased SP tear levels were also demonstrated in patients with seasonal allergic conjunctivitis [23].
Positive_regulation (increase) of SP in plasma associated with conjunctivitis, conjunctiva disease and substance p
17) Confidence 0.15 Published 2011 Journal Molecular Vision Section Body Doc Link PMC3021574 Disease Relevance 0.77 Pain Relevance 0.36
In this study we also show that SP, CGRP, and VIP are normally present in tears of allergic subjects and increase after conjunctival allergen challenge.
Positive_regulation (increase) of SP in tears associated with hypersensitivity and substance p
18) Confidence 0.12 Published 2011 Journal Molecular Vision Section Body Doc Link PMC3021574 Disease Relevance 0.74 Pain Relevance 0.40
In this study we demonstrate that neuromediators are normally present in tears of healthy subjects, and that SP, CGRP, and VIP are increased after conjunctival allergen challenge in allergic patients.
Positive_regulation (increased) of SP in tears associated with hypersensitivity and substance p
19) Confidence 0.12 Published 2011 Journal Molecular Vision Section Body Doc Link PMC3021574 Disease Relevance 0.25 Pain Relevance 0.37
Specifically, an increase of SP tear and plasma levels has been described in patients with VKC [24] and increased SP tear levels were also demonstrated in patients with seasonal allergic conjunctivitis [23].
Positive_regulation (increased) of SP in plasma associated with conjunctivitis, conjunctiva disease and substance p
20) Confidence 0.10 Published 2011 Journal Molecular Vision Section Body Doc Link PMC3021574 Disease Relevance 0.75 Pain Relevance 0.39

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