INT8838

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Context Info
Confidence 0.49
First Reported 1986
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 0.86
Pain Relevance 4.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TAC1) extracellular region (TAC1) plasma membrane (TAC1)
cell-cell signaling (TAC1)
Anatomy Link Frequency
nerve 4
neuronal 2
nasal 2
dorsal horn 2
TAC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 26 100.00 Very High Very High Very High
Neuropeptide 11 100.00 Very High Very High Very High
Serotonin 7 100.00 Very High Very High Very High
Calcitonin gene-related peptide 6 100.00 Very High Very High Very High
bradykinin 6 100.00 Very High Very High Very High
qutenza 33 99.98 Very High Very High Very High
c fibre 3 99.74 Very High Very High Very High
Dorsal column 2 99.74 Very High Very High Very High
Dorsal horn 4 99.52 Very High Very High Very High
nociceptor 1 99.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 3 99.56 Very High Very High Very High
Rhinitis 4 98.48 Very High Very High Very High
Pain 2 97.44 Very High Very High Very High
Hypotension 2 92.72 High High
Polyps 3 57.28 Quite High
Ganglion Cysts 1 44.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
More recently, both functional and neurochemical evidence have been accumulated that BK evokes release of neuropeptides, including calcitonin gene-related peptide and the tachykinins substance P and neurokinin A, from peripheral terminals of capsaicin-sensitive primary afferents.
Positive_regulation (accumulated) of Localization (release) of neurokinin A associated with qutenza, neuropeptide, bradykinin, substance p and calcitonin gene-related peptide
1) Confidence 0.49 Published 1993 Journal Regul. Pept. Section Abstract Doc Link 8210518 Disease Relevance 0 Pain Relevance 0.55
In this in vivo prospective, controlled study, we have examined the capsaicin-induced levels and secretion patterns of the colocalized neuropeptides substance P, calcitonin gene-related peptide (CGRP), and neurokinin A in nasal secretions of subjects with nasal polyps, and we compared these with secretion patterns from healthy subjects and from subjects with allergic rhinitis.
Spec (examined) Positive_regulation (induced) of Localization (secretion) of neurokinin A in nasal associated with rhinitis, qutenza, neuropeptide, calcitonin gene-related peptide and substance p
2) Confidence 0.45 Published 1999 Journal Otolaryngol Head Neck Surg Section Abstract Doc Link 10547475 Disease Relevance 0.40 Pain Relevance 0.80
No detectable release of NKB- or NPK-LI was induced by capsaicin.
Positive_regulation (induced) of Localization (release) of NPK associated with qutenza
3) Confidence 0.29 Published 1986 Journal Acta Physiol Scand Suppl Section Abstract Doc Link 2430427 Disease Relevance 0.18 Pain Relevance 0.72
Dorsal column stimulation induces release of serotonin and substance P in the cat dorsal horn.
Positive_regulation (induces) of Localization (release) of substance P in dorsal horn associated with dorsal horn, serotonin, substance p and dorsal column
4) Confidence 0.28 Published 1992 Journal Neurosurgery Section Title Doc Link 1381066 Disease Relevance 0.19 Pain Relevance 0.87
Retrograde or antidromic stimulation of the nociceptive C fibres is known to lead to the release of sensory neuropeptides Substance P (SP) and Calcitonin Gene-Related Peptide (CGRP) by the peripheral endings of these ultra-thin nerve fibres.
Positive_regulation (lead) of Localization (release) of Substance P in nerve associated with nociception, c fibre, neuropeptide and substance p
5) Confidence 0.22 Published 2003 Journal Acta Orthop Belg Section Abstract Doc Link 14748110 Disease Relevance 0.10 Pain Relevance 0.32
No detectable release of neurokinin B or neuropeptide K, an N-terminally extended form of neurokinin A, was induced by capsaicin.
Positive_regulation (induced) of Localization (release) of neurokinin B associated with qutenza and neuropeptide
6) Confidence 0.03 Published 1986 Journal Neuroscience Section Abstract Doc Link 2431350 Disease Relevance 0 Pain Relevance 0.87
Exposure to ozone (O3) induces airway hyperresponsiveness mediated partly through the release of substance P (SP) from nerve terminals in the airway wall.
Positive_regulation (mediated) of Localization (release) of substance P in nerve associated with substance p
7) Confidence 0.02 Published 2003 Journal J. Appl. Physiol. Section Abstract Doc Link 12730146 Disease Relevance 0 Pain Relevance 0.28
These data indicate that an endogenous tachykinin release contributes to the ongoing activity of the locomotor network by modulating the glutamate-glycine neuronal network responsible for the locomotor pattern.
Positive_regulation (contributes) of Localization (release) of endogenous tachykinin in neuronal associated with glutamate
8) Confidence 0.01 Published 2007 Journal J. Neurophysiol. Section Abstract Doc Link 17360825 Disease Relevance 0 Pain Relevance 0.29

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