INT8839

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Context Info
Confidence 0.24
First Reported 1992
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 2.90
Pain Relevance 2.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SFTPA1) extracellular region (SFTPA1)
Anatomy Link Frequency
plasma 3
eyes 2
dorsal root 2
incisor 2
tear 1
SFTPA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 121 100.00 Very High Very High Very High
Neuropeptide 77 96.64 Very High Very High Very High
Dorsal horn 4 93.92 High High
Inflammation 22 89.12 High High
Serotonin 6 87.84 High High
qutenza 1 81.72 Quite High
Pain 5 80.00 Quite High
Dorsal column 2 75.00 Quite High
Inflammatory response 5 54.40 Quite High
Spinal cord 1 53.96 Quite High
Disease Link Frequency Relevance Heat
Conjunctiva Disease 30 100.00 Very High Very High Very High
Hypersensitivity 114 99.24 Very High Very High Very High
Nociception 2 98.68 Very High Very High Very High
Conjunctivitis 12 97.76 Very High Very High Very High
Disease 15 93.24 High High
Pain 5 84.64 Quite High
INFLAMMATION 21 75.00 Quite High
Disorders Of The Lacrimal System 9 72.56 Quite High
Adhesions 3 68.08 Quite High
Pruritus 18 49.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, no release of SP could be recorded in response to DCS in the decerebrated preparation, although peripheral nociceptive stimulation (pinch) and noxious electric dorsal root stimulation induced an elevation of the SP levels.
Positive_regulation (induced) of Positive_regulation (elevation) of SP in dorsal root associated with nociception and substance p
1) Confidence 0.24 Published 1992 Journal Neurosurgery Section Abstract Doc Link 1381066 Disease Relevance 0.15 Pain Relevance 0.84
Our studies indicate that SP-induced cellular Ca+2 signals led to the activation of the NF-kappaB pathway, resulting in nuclear translocation of p65/p50 heterodimers that bind to high-affinity tandem kappaB sites on the VCAM-1 promoter, whereas SP activation induced NF-AT activation and ICAM-1 DNA binding.
Positive_regulation (induced) of Positive_regulation (activation) of SP associated with substance p
2) Confidence 0.15 Published 2000 Journal J. Investig. Dermatol. Symp. Proc. Section Abstract Doc Link 11147679 Disease Relevance 0.26 Pain Relevance 0.50
However, using a “paired Wilcoxon Rank test” for statistical analysis –which analyses the magnitude of the difference in paired samples– allowed us to convincingly demonstrate the increase of SP, CGRP and VIP tear levels after CPT only in eyes challenged with allergen.
Positive_regulation (increase) of Positive_regulation (increase) of SP in eyes associated with substance p
3) Confidence 0.12 Published 2011 Journal Molecular Vision Section Body Doc Link PMC3021574 Disease Relevance 0.86 Pain Relevance 0.32
Specifically, an increase of SP tear and plasma levels has been described in patients with VKC [24] and increased SP tear levels were also demonstrated in patients with seasonal allergic conjunctivitis [23].
Positive_regulation (increased) of Positive_regulation (increase) of SP in plasma associated with conjunctivitis, conjunctiva disease and substance p
4) Confidence 0.11 Published 2011 Journal Molecular Vision Section Body Doc Link PMC3021574 Disease Relevance 0.77 Pain Relevance 0.40
RESULTS: Painful stimulation of the upper central incisor caused significant elevations in GCF SP and MMP-8 levels of the stimulated tooth.
Positive_regulation (caused) of Positive_regulation (elevations) of SP in incisor
5) Confidence 0.08 Published 2008 Journal Acta Odontol. Scand. Section Body Doc Link 18320414 Disease Relevance 0.08 Pain Relevance 0
Specifically, an increase of SP tear and plasma levels has been described in patients with VKC [24] and increased SP tear levels were also demonstrated in patients with seasonal allergic conjunctivitis [23].
Positive_regulation (increased) of in tear Positive_regulation (increase) of SP in plasma associated with conjunctivitis, conjunctiva disease and substance p
6) Confidence 0.04 Published 2011 Journal Molecular Vision Section Body Doc Link PMC3021574 Disease Relevance 0.77 Pain Relevance 0.40

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