INT88635

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Context Info
Confidence 0.05
First Reported 2000
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Calca) intracellular (Calca) cytoplasm (Calca)
signal transducer activity (Ptger3) extracellular space (Calca) extracellular region (Calca)
Anatomy Link Frequency
skin 2
Ptger3 (Rattus norvegicus)
Calca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 2 100.00 Very High Very High Very High
Nerve growth factor 8 99.38 Very High Very High Very High
Calcitonin gene-related peptide 5 90.52 High High
c fibre 1 86.96 High High
Action potential 1 85.72 High High
Kinase C 1 83.60 Quite High
nociceptor 8 80.00 Quite High
Neuropeptide 1 75.08 Quite High
bradykinin 1 59.56 Quite High
neuropeptide release 1 37.92 Quite Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, 100 microM PGE(2) plus PGI(2) failed to increase the iCGRP release induced by noxious heat (47 degrees C) from the isolated rat skin.
PGE Neg (failed) Positive_regulation (increase) of Localization (release) of iCGRP in skin
1) Confidence 0.05 Published 2007 Journal Life Sci. Section Abstract Doc Link 17976660 Disease Relevance 0 Pain Relevance 0.75
Independent of NGF treatment, exposure to 100 nM PGE(2) augmented capsaicin- or potassium-stimulated release of iCGRP by 1. 5-fold compared with cells not exposed to PGE(2).
PGE Positive_regulation (augmented) of Localization (release) of iCGRP associated with qutenza and nerve growth factor
2) Confidence 0.03 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10841984 Disease Relevance 0 Pain Relevance 0.49

General Comments

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