INT88694

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Context Info
Confidence 0.75
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 17
Total Number 23
Disease Relevance 21.88
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (WT1) nucleolus (WT1) RNA binding (WT1)
nucleus (WT1) intracellular (WT1) cytoplasm (WT1)
Anatomy Link Frequency
bone marrow 4
neurons 2
mesoderm 1
mesothelium 1
hematopoietic cells 1
WT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 9 99.70 Very High Very High Very High
endometriosis 2 99.20 Very High Very High Very High
Pain 19 95.08 Very High Very High Very High
Angina 1 88.48 High High
abdominal pain 19 72.44 Quite High
fibrosis 9 42.56 Quite Low
Freund adjuvant 7 35.28 Quite Low
chemokine 56 5.00 Very Low Very Low Very Low
cytokine 49 5.00 Very Low Very Low Very Low
antagonist 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 406 100.00 Very High Very High Very High
Cancer 775 99.96 Very High Very High Very High
Cold Sores 432 99.84 Very High Very High Very High
Malignant Neoplastic Disease 60 99.62 Very High Very High Very High
Leukemia 98 99.60 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 464 99.28 Very High Very High Very High
Endometriosis (extended) 2 99.20 Very High Very High Very High
Myeloid Leukemia 287 99.08 Very High Very High Very High
Infection 131 98.52 Very High Very High Very High
Carcinoma 13 97.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Wilms' tumor gene 1 (WT1) overexpression in neurons in deep endometriosis: a pilot study.
Gene_expression (overexpression) of WT1 in neurons associated with endometriosis and cancer
1) Confidence 0.75 Published 2009 Journal Fertil. Steril. Section Title Doc Link 18722603 Disease Relevance 0.39 Pain Relevance 0.19
The high frequency of DSRCTs with WT1 protein expression suggests that in consensus with clinical tomographic and cytological findings, this antibody may be used to confirm the diagnosis of DSRCT in cytological samples.
Gene_expression (expression) of WT1
2) Confidence 0.75 Published 2005 Journal Cytojournal Section Body Doc Link PMC555739 Disease Relevance 0.98 Pain Relevance 0.04
Normal WT1 protein is expressed in tissues, which undergo mesenchymal-epithelial conversion derived from mesoderm, in a specific period of development [20] and it plays a role in mesothelial formation in embryonic development [21].
Gene_expression (expressed) of WT1 in mesoderm
3) Confidence 0.75 Published 2005 Journal Cytojournal Section Body Doc Link PMC555739 Disease Relevance 0.55 Pain Relevance 0.03
This translocation produces the chimeric transcript EWS/WT1 and the related WT1 protein, which can be detected by immunohistochemical method.
Gene_expression (produces) of WT1
4) Confidence 0.75 Published 2005 Journal Cytojournal Section Body Doc Link PMC555739 Disease Relevance 0.29 Pain Relevance 0
This translocation produces the chimeric transcript EWS/WT1 and the related WT1 protein, which can be detected by immunohistochemical method.
Gene_expression (produces) of WT1
5) Confidence 0.75 Published 2005 Journal Cytojournal Section Body Doc Link PMC555739 Disease Relevance 0.28 Pain Relevance 0
In addiction to consistent WT1 expression, the typical serosal involvement in DSRCT has raised the possibility that this tumor might be a blastematous tumour derived of primitive mesothelium [24].
Gene_expression (expression) of WT1 in mesothelium associated with addiction and cancer
6) Confidence 0.75 Published 2005 Journal Cytojournal Section Body Doc Link PMC555739 Disease Relevance 0.78 Pain Relevance 0.05
Immunohistochemically, the tumor cells were positive for anti-epithelial membrane antigen, vimentin, desmin, neuron-specific enolase and WT1 protein antibodies.
Gene_expression (antibodies) of WT1 in neuron associated with cancer
7) Confidence 0.65 Published 2000 Journal Pathol. Int. Section Abstract Doc Link 10849332 Disease Relevance 0.95 Pain Relevance 0.07
Immunohistochemical detection of WT1 in DSRCTs is predictive of the translocation and it also demonstrates that the chimeric protein is expressed in significant amount in tumour cells 22, 23.
Gene_expression (detection) of WT1 associated with cancer
8) Confidence 0.65 Published 2005 Journal Cytojournal Section Body Doc Link PMC555739 Disease Relevance 0.63 Pain Relevance 0.04
We detected WT1 immunoreactivity in all tumors tissues and in 2 out of 3 serous effusions with malignant cells, as well as on FNAB smears.
Gene_expression (detected) of WT1 associated with malignant neoplastic disease and cancer
9) Confidence 0.65 Published 2005 Journal Cytojournal Section Body Doc Link PMC555739 Disease Relevance 0.83 Pain Relevance 0.04
Only 10 of these patients could be evaluated with regard to clinical responses: (i) 2 patients showed decreased residual AML; (ii) stable disease was seen for 2 patients; (iii) bone marrow expression of WT1 was used as a surrogate marker of residual disease for those patients without detectable AML blasts, and for 5 of these patients decreased expression was detected following vaccination; (iv) 1 patient showed progressive disease.
Gene_expression (expression) of WT1 in bone marrow associated with myeloid leukemia and disease
10) Confidence 0.61 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896720 Disease Relevance 0.95 Pain Relevance 0
All patients were HLA-A2402 positive and their malignant cells showed high WT1 expression.
Gene_expression (expression) of WT1 associated with malignant neoplastic disease
11) Confidence 0.61 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896720 Disease Relevance 1.00 Pain Relevance 0
Reduction of bone marrow WT1 levels was observed for a subset of patients following vaccination.
Gene_expression (levels) of WT1 in bone marrow
12) Confidence 0.61 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896720 Disease Relevance 0.64 Pain Relevance 0
All patients were HLA-A2 positive and had high expression of WT1 in their leukemia cells, 17 out of the 19 included patients had received previous chemotherapy and all patients had detectable AML with increased bone marrow blasts.
Gene_expression (expression) of WT1 in bone marrow associated with leukemia and myeloid leukemia
13) Confidence 0.61 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896720 Disease Relevance 0.67 Pain Relevance 0
This translocation produces the chimeric transcript EWS/WT1 and the related WT1 protein, which can be detected by immunohistochemical method.
Gene_expression (detected) of WT1
14) Confidence 0.58 Published 2005 Journal Cytojournal Section Body Doc Link PMC555739 Disease Relevance 0.29 Pain Relevance 0
Tumor cells also expressed WT1 protein.


Gene_expression (expressed) of WT1 associated with cancer
15) Confidence 0.58 Published 2005 Journal Cytojournal Section Body Doc Link PMC555739 Disease Relevance 0.62 Pain Relevance 0
HIV incidence was highest among HSV-2 seroconverters, particularly if they reported GUD symptoms, and the risk of HIV acquisition was lower but not statistically significant in circumcised compared to uncircumcised men who acquired HSV-2 (IRR?
Gene_expression (symptoms) of GUD associated with cold sores, acquired immune deficiency syndrome or hiv infection and disease
16) Confidence 0.54 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2771764 Disease Relevance 1.60 Pain Relevance 0
0.89, 95% CI 0.49–1.60), irrespective of whether the prevalent HSV-2 positive men reported GUD symptoms (IRR?
Gene_expression (symptoms) of GUD associated with cold sores and disease
17) Confidence 0.54 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2771764 Disease Relevance 1.39 Pain Relevance 0
It is noteworthy that the efficacy of circumcision for prevention of clinically observed GUD at time of a study visit (PRR?
Gene_expression (observed) of GUD associated with disease
18) Confidence 0.54 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2771764 Disease Relevance 1.07 Pain Relevance 0
Circumcision significantly reduced symptomatic GUD in HSV-2-seronegative men (PRR?
Gene_expression (symptomatic) of GUD associated with cold sores and disease
19) Confidence 0.54 Published 2009 Journal PLoS Medicine Section Abstract Doc Link PMC2771764 Disease Relevance 3.17 Pain Relevance 0
Bone marrow expression of WT1 was used as a surrogate marker for residual disease, and these levels decreased when immunological responses became detectable.
Gene_expression (expression) of WT1 in Bone marrow associated with disease
20) Confidence 0.47 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896720 Disease Relevance 0.85 Pain Relevance 0

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