INT88734

Context Info Confidence 0.27 First Reported 2000 Last Reported 2010 Negated 1 Speculated 1 Reported most in Body Documents 10 Total Number 11 Disease Relevance 2.01 Pain Relevance 0.21

cell differentiation (CREM) signal transduction (CREM) nucleus (CREM) DNA binding (CREM)

CREM (Homo sapiens)

Pain Link Frequency Relevance Heat agonist 30 82.32 Pain 73 56.04 Post herpetic neuralgia 110 50.00 cINOD 6 50.00 nud 3 50.00 rheumatoid arthritis 2 50.00 antagonist 2 40.00 beta blocker 1 37.44 Neuropathic pain 5 32.76 Osteoarthritis 40 5.00

Disease Link Frequency Relevance Heat Malaria 279 98.88 Disease 50 94.24 Polyps 31 87.88 Death 33 81.52 Obesity 15 80.16 Herpes Zoster 123 72.88 Disorder Of Lipid Metabolism 14 70.16 Fever 51 68.80 Ulcers 4 61.20 Pain 70 56.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Each ICER was highly sensitive to variation in the cost of the tests themselves.

Regulation (sensitive) of ICER

1) Confidence 0.27 Published 2000 Journal Can. J. Gastroenterol. Section Body Doc Link 10851277 Disease Relevance 0.06 Pain Relevance 0

According to the sensitivity analyses, QALYs had the highest influence on ICER.

Regulation (influence) of ICER

2) Confidence 0.12 Published 2009 Journal Int J Technol Assess Health Care Section Body Doc Link 19366498 Disease Relevance 0 Pain Relevance 0

The 95% confidence interval for this ratio was estimated using Fieller's Theorem, a technique that includes any correlation between cost and outcome.12 Cost-effectiveness acceptability curves (CEACs), which allow decision-makers to assess the overall probability of a particular threshold, were also estimated.13 A CEAC shows combinations of ceiling values for the ICER and the probabilities that the ICER falls below any given ceiling ratio based on the observed size and variance of differences in cost and events in the trial.

Spec (probabilities) Regulation (values) of ICER

3) Confidence 0.10 Published 2010 Journal European Journal of Heart Failure Section Body Doc Link PMC2796144 Disease Relevance 0 Pain Relevance 0

ICER was sensitive to changes in cost of RDT.

Regulation (sensitive) of ICER

4) Confidence 0.08 Published 2009 Journal Malar J Section Body Doc Link PMC2787522 Disease Relevance 0.27 Pain Relevance 0

ICER was sensitive to deterministic values of malaria prevalence.

Regulation (sensitive) of ICER associated with malaria

5) Confidence 0.08 Published 2009 Journal Malar J Section Body Doc Link PMC2787522 Disease Relevance 0.45 Pain Relevance 0

ICER was very sensitive to a 50% rise in cost of ACT (Table 11).

Regulation (sensitive) of ICER

6) Confidence 0.08 Published 2009 Journal Malar J Section Body Doc Link PMC2787522 Disease Relevance 0.32 Pain Relevance 0

However, using the yardstick that any intervention whose ICER is in excess of three times the per capita GNP is not cost effective, then adding any of the screening programmes to treatment will not be considered as being cost effective.

Neg (not) Regulation (effective) of ICER

7) Confidence 0.06 Published 2010 Journal Cost Eff Resour Alloc Section Body Doc Link PMC2850877 Disease Relevance 0.29 Pain Relevance 0

In women less than age 55, the ICER of MoM HRA is less sensitive to the incremental cost of the HRA implants compared to THA, due to the higher probability of HRA failure in women than in men.Fig. 5A–DThese graphs show two-way sensitivity analyses of incremental cost of HRA compared to primary THA and difference in QoL after conversion from HRA to THA compared to primary THA for (A) men younger than 55 years, (B) men aged 65 to 74 years, (C) women younger than 55 years, and (D) women aged 65 to 74 years.

Regulation (sensitive) of ICER

8) Confidence 0.04 Published 2010 Journal Clin Orthop Relat Res Section Body Doc Link PMC2914258 Disease Relevance 0 Pain Relevance 0

The one-way sensitivity analysis of the ICER to the difference in QoL after conversion from HRA to THA compared to primary THA indicated that the ICER for MoM HRA was very sensitive to the differences in QoL after conversion from HRA to THA for both men and women less than age 55, but not for men age 55–64 (Fig. 3).

Regulation (sensitive) of ICER

9) Confidence 0.04 Published 2010 Journal Clin Orthop Relat Res Section Body Doc Link PMC2914258 Disease Relevance 0 Pain Relevance 0

The sensitivity of the base case ICER to alternative values of significant input parameters was explored by varying these within feasible ranges.

Regulation (sensitivity) of ICER

10) Confidence 0.04 Published 2010 Journal Cost Eff Resour Alloc Section Body Doc Link PMC2881001 Disease Relevance 0.28 Pain Relevance 0.11

The DNA response element conferring PPAR regulation was located to intron 3 of the Angptl4 gene [127].

Regulation (regulation) of DNA response element

11) Confidence 0.00 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.34 Pain Relevance 0.11

General Comments

This test has worked.