INT88778

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Context Info
Confidence 0.21
First Reported 2000
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.56
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1, Pomc) cell-cell signaling (Pomc) cytoplasm (Pomc)
signal transducer activity (Oprm1) extracellular space (Pomc) generation of precursor metabolites and energy (Pomc)
Anatomy Link Frequency
T cells 1
Oprm1 (Mus musculus)
Pomc (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 13 100.00 Very High Very High Very High
narcan 1 95.44 Very High Very High Very High
Visceral pain 2 87.60 High High
Endogenous opioid 2 86.08 High High
Opioid 3 84.08 Quite High
cytokine 1 82.80 Quite High
Pain 1 59.16 Quite High
nud 1 58.92 Quite High
Antinociceptive 1 50.04 Quite High
Disease Link Frequency Relevance Heat
Neuroblastoma 2 98.36 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

2 87.60 High High
Pain 1 59.16 Quite High
Dyspepsia 1 58.92 Quite High
Immunodeficiency 1 57.72 Quite High
Severe Combined Immunodeficiency 1 56.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, our results suggest that nonpolarized CD4+ T cells release beta-endorphin, which, through an interaction with MOR, stimulates an upregulation of beta-endorphin expression in the myenteric plexus.
MOR Binding (interaction) of beta-endorphin in T cells associated with opioid receptor
1) Confidence 0.21 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16959949 Disease Relevance 0.23 Pain Relevance 0.69
To determine if this protein is indeed a degraded receptor fragment, (125)I-beta-endorphin was cross-linked to the (His)(6) epitope-tagged mu-opioid receptor (His-mu) stably expressed in the murine neuroblastoma Neuro(2A) cells.
epitope-tagged mu-opioid receptor Binding (cross-linked) of I-beta-endorphin associated with neuroblastoma and opioid receptor
2) Confidence 0.13 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10854259 Disease Relevance 0.10 Pain Relevance 0.21
Initial cross-linking experiments indicated the absolute requirement of the high-affinity (125)I-beta-endorphin binding to the mu-opioid receptor prior to the appearance of the low molecular weight species, suggesting that the 22-kDa protein could be a degraded fragment of the receptor.
mu-opioid receptor Binding (binding) of I-beta-endorphin associated with opioid receptor
3) Confidence 0.12 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10854259 Disease Relevance 0.09 Pain Relevance 0.24

General Comments

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