INT88868

Context Info Confidence 0.40 First Reported 2000 Last Reported 2010 Negated 2 Speculated 5 Reported most in Body Documents 45 Total Number 52 Disease Relevance 37.43 Pain Relevance 7.98

Anatomy Link Frequency blood 1 sulcus 1 MCS 1 upper 1 Body 1 MCS (Homo sapiens)

Pain Link Frequency Relevance Heat Fibrositis 544 99.88 depression 489 99.76 antidepressant 76 99.76 Inflammation 14 99.40 Pain 389 99.26 alcohol 47 97.68 visual analogue scale 52 96.16 qutenza 7 95.60 nud 54 93.34 headache 25 84.96

Disease Link Frequency Relevance Heat Chronic Fatigue Syndrome 742 100.00 Multiple Chemical Sensitivity 344 100.00 Obesity 186 100.00 Syndrome 23 100.00 Fibromyalgia 184 99.88 Depression 571 99.76 Cancer 117 99.60 Mental Disorders 339 99.58 INFLAMMATION 12 99.40 Neurosis 12 99.34

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

There was, however, a significant interaction of MCS action with the patients' age, reflecting a significant delay during MCS of the cognitive responses N2 and P3 (N200 and P300) in the group of patients older than 50 years exclusively.

MCS Binding (interaction) of in MCS associated with cognitive disorder

1) Confidence 0.40 Published 2002 Journal Neurophysiol Clin Section Abstract Doc Link 12490329 Disease Relevance 0.62 Pain Relevance 0.36

Post hoc analyses revealed that individuals with CFS-MCS-FM had significantly more interference in functioning due to pain than individuals with CFS alone and individuals with CFS-MCS.

CFS-MCS Binding (individuals) of associated with multiple chemical sensitivity, pain, chronic fatigue syndrome and fibrositis

2) Confidence 0.35 Published 2007 Journal Dyn Med Section Body Doc Link PMC1890280 Disease Relevance 3.70 Pain Relevance 0.96

Our findings regarding the two groups that included individuals with MCS (CFS- MCS and CFS-MCS-FM) are consistent with previous research suggesting that individuals with MCS tend to have low scores on the SF-36 health status scales [56].

MCS Binding (individuals) of associated with multiple chemical sensitivity, chronic fatigue syndrome and fibrositis

3) Confidence 0.35 Published 2007 Journal Dyn Med Section Body Doc Link PMC1890280 Disease Relevance 2.72 Pain Relevance 0.41

AIMS: To examine associations between fatigue, depression and MCs of the colonic mucosa in IBS.

MCs Binding (associations) of in MCs

4) Confidence 0.35 Published 2008 Journal Gut Section Body Doc Link 18194987 Disease Relevance 0 Pain Relevance 0

The only physical signs associated with MCS (upper airway inflammation and obstruction) can aggravate SA. 3.

MCS Binding (associated) of in upper associated with apnoea, inflammation and syndrome

5) Confidence 0.31 Published 2000 Journal Med. Hypotheses Section Abstract Doc Link 10859679 Disease Relevance 2.45 Pain Relevance 0.13

SIGNIFICANCE: The present findings suggest that an intra-central sulcus is one of the favorable targets for MCS.

MCS Binding (targets) of in sulcus

6) Confidence 0.31 Published 2008 Journal Clin Neurophysiol Section Body Doc Link 18329955 Disease Relevance 0 Pain Relevance 0

Our findings regarding the two groups that included individuals with MCS (CFS- MCS and CFS-MCS-FM) are consistent with previous research suggesting that individuals with MCS tend to have low scores on the SF-36 health status scales [56].

MCS Binding (individuals) of associated with multiple chemical sensitivity, chronic fatigue syndrome and fibrositis

7) Confidence 0.30 Published 2007 Journal Dyn Med Section Body Doc Link PMC1890280 Disease Relevance 2.71 Pain Relevance 0.45

Individuals with CFS-MCS, and individuals with CFS-MCS-FM used significantly more self distraction than individuals with CFS alone.

CFS-MCS Binding (Individuals) of associated with multiple chemical sensitivity, chronic fatigue syndrome and fibrositis

8) Confidence 0.30 Published 2007 Journal Dyn Med Section Body Doc Link PMC1890280 Disease Relevance 3.67 Pain Relevance 1.05

It has been hypothesized that individuals with MCS may consider chemical exposure to be unavoidable, leading them to utilize passive coping [58].

MCS Binding (individuals) of associated with multiple chemical sensitivity

9) Confidence 0.30 Published 2007 Journal Dyn Med Section Body Doc Link PMC1890280 Disease Relevance 3.19 Pain Relevance 0.75

Internalizing behavior symptoms were associated with only a small effect on caregiver's MCS score, again with wide confidence intervals around the beta coefficients for both samples.

MCS Binding (associated) of

10) Confidence 0.27 Published 2004 Journal BMC Pediatr Section Body Doc Link PMC544865 Disease Relevance 0.35 Pain Relevance 0

Education was also associated with MCS.

MCS Binding (associated) of

11) Confidence 0.26 Published 2004 Journal BMC Pediatr Section Body Doc Link PMC544865 Disease Relevance 0.22 Pain Relevance 0

Although other interaction terms with NICU status did not add any more significant results in the pooled model (non-significant partial F-test), we examined separate models for the NICU and the healthy baby group to further explore the association between gender and MCS score, and to evaluate the potential influence of congenital anomalies in NICU group.

MCS Spec (examined) Binding (association) of associated with congenital anomalies

12) Confidence 0.26 Published 2004 Journal BMC Pediatr Section Body Doc Link PMC544865 Disease Relevance 0.25 Pain Relevance 0

Lower parent-reported child quality of life was also associated with a lower parental MCS.

MCS Binding (associated) of

13) Confidence 0.26 Published 2004 Journal BMC Pediatr Section Body Doc Link PMC544865 Disease Relevance 0.15 Pain Relevance 0

The magnitude of these changes was 9 points for SF-36 MCS and 16 points for MH.

SF-36 MCS Binding (points) of associated with mental disorders

14) Confidence 0.18 Published 2010 Journal Advances in Physiotherapy Section Body Doc Link PMC2956448 Disease Relevance 0.97 Pain Relevance 0.03

Finally, regression analyses were applied to determine the effects of variables associated with PCS and MCS.

MCS Binding (associated) of

15) Confidence 0.18 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2819993 Disease Relevance 0.75 Pain Relevance 0.03

CONCLUSION: The results of this study have shown that musculoskeletal pain was strongly associated with lower scores on the PCS and MCS, and depression was strongly associated with a lower score on the MCS.

MCS Binding (associated) of

16) Confidence 0.17 Published 2009 Journal Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery Section Body Doc Link 19342310 Disease Relevance 0 Pain Relevance 0

Mental health problems, sexual abuse, physical abuse, the use of sedatives, the use of cocaine, the number of days of cocaine use, sedative use and multiple substance use in the past month were significantly associated with MCS.

MCS Binding (associated) of

17) Confidence 0.16 Published 2006 Journal Eur Addict Res Section Body Doc Link 16543742 Disease Relevance 0 Pain Relevance 0

In order to investigate its association to the number of infiltrated MCs, the drug-related fatalities were divided into two groups according to their level of blood tryptase.

MCs Binding (association) of in blood

18) Confidence 0.16 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350147 Disease Relevance 0.22 Pain Relevance 0.03

Average pixel intensity = mCS

mCS Binding (intensity) of

19) Confidence 0.12 Published 2002 Journal BMC Public Health Section Body Doc Link PMC128828 Disease Relevance 0.47 Pain Relevance 0.05

The results suggest that the C5 is not reliable for diagnosing MCS but C5 can be used to verify presence of lower airway symptoms related to odorous chemicals.

MCS Binding (diagnosing) of

20) Confidence 0.09 Published 2010 Journal Int J Hyg Environ Health Section Abstract Doc Link 19773199 Disease Relevance 0.92 Pain Relevance 0.35

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