INT88924

Context Info Confidence 0.41 First Reported 2000 Last Reported 2004 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 1.77 Pain Relevance 0.20

peptidase activity (FAP) extracellular space (FAP) plasma membrane (FAP)

FAP (Homo sapiens)

Pain Link Frequency Relevance Heat Opioid 1 96.04 cINOD 2 51.60

Disease Link Frequency Relevance Heat Familial Adenomatous Polyposis 8 100.00 Polyps 5 99.96 Cancer 5 99.60 Colon Cancer 3 88.60 Carcinoma 1 65.20 Adenoma 2 64.64 INFLAMMATION 1 51.04 Adenomatous Polyps 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Adduct levels in colonic epithelia decreased in the order: FAP polyps > tumor-adjacent tissue > tumor, normal and tumor-distal tissue.

Negative_regulation (decreased) of FAP associated with cancer, familial adenomatous polyposis and polyps

1) Confidence 0.41 Published 2000 Journal Int. J. Cancer Section Abstract Doc Link 10861445 Disease Relevance 1.77 Pain Relevance 0.10

In this paper, we report an inhibitory effect of these peptides on dipeptidyl peptidase IV (DPPIV) activity, known to be involved in regulatory functions such as the activation or inactivation of peptides.

Negative_regulation (effect) of DPPIV

2) Confidence 0.03 Published 2004 Journal Biochimie Section Abstract Doc Link 14987798 Disease Relevance 0 Pain Relevance 0.10

General Comments

This test has worked.