INT89103

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Context Info
Confidence 0.56
First Reported 2000
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 8.11
Pain Relevance 4.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (TGFB1) enzyme binding (TGFB1) embryo development (TGFB1)
cytoplasm (TGFB1) extracellular space (TGFB1) extracellular region (TGFB1)
Anatomy Link Frequency
fibroblast 4
endometrium 4
articular 2
epithelial cells 2
TGFB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 16 99.90 Very High Very High Very High
aspirin 101 99.20 Very High Very High Very High
endometriosis 46 98.88 Very High Very High Very High
Snapping jaw 5 97.36 Very High Very High Very High
cytokine 52 96.88 Very High Very High Very High
Arthritis 21 96.28 Very High Very High Very High
Osteoarthritis 20 95.64 Very High Very High Very High
Inflammation 107 93.60 High High
antagonist 3 86.96 High High
Pain 5 86.08 High High
Disease Link Frequency Relevance Heat
Injury 24 99.98 Very High Very High Very High
Adhesions 54 99.06 Very High Very High Very High
Endometriosis 48 98.88 Very High Very High Very High
Metastasis 2 97.68 Very High Very High Very High
Temporomandibular Joint Syndrome 5 97.36 Very High Very High Very High
Endometriosis (extended) 5 97.00 Very High Very High Very High
Colitis 8 96.48 Very High Very High Very High
Arthritis 30 96.28 Very High Very High Very High
Cancer 79 96.08 Very High Very High Very High
Osteoarthritis 20 95.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since these two systems interact in several other tissues we postulated that opioids may affect the production of TGFbeta1 in human endometrium.
Spec (may) Regulation (affect) of Gene_expression (production) of TGFbeta1 in endometrium associated with opioid
1) Confidence 0.56 Published 2000 Journal Mol. Hum. Reprod. Section Abstract Doc Link 10871647 Disease Relevance 0.08 Pain Relevance 0.67
The nitrate levels also directly correlated with the levels of TGF-?
Regulation (correlated) of Gene_expression (levels) of TGF
2) Confidence 0.44 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165041 Disease Relevance 0.88 Pain Relevance 0.34
IL-1beta etiologically correlated with joint pathology, whereas TGFbeta expression associated with IL-1beta down-regulation and improvement of articular pathology.
Regulation (regulation) of Gene_expression (expression) of TGFbeta in articular
3) Confidence 0.42 Published 2009 Journal J. Dent. Res. Section Abstract Doc Link 19587162 Disease Relevance 1.16 Pain Relevance 0.74
Hyaluronic acid modulates gene expression of connective tissue growth factor (CTGF), transforming growth factor-beta1 (TGF-beta1), and vascular endothelial growth factor (VEGF) in human fibroblast-like synovial cells from advanced-stage osteoarthritis in vitro.
Regulation (modulates) of Gene_expression (expression) of TGF-beta1 in fibroblast associated with osteoarthritis
4) Confidence 0.40 Published 2010 Journal J. Orthop. Res. Section Title Doc Link 19890996 Disease Relevance 0.58 Pain Relevance 0.30
Hyaluronic acid modulates gene expression of connective tissue growth factor (CTGF), transforming growth factor-beta1 (TGF-beta1), and vascular endothelial growth factor (VEGF) in human fibroblast-like synovial cells from advanced-stage osteoarthritis in vitro.
Regulation (modulates) of Gene_expression (expression) of transforming growth factor-beta1 in fibroblast associated with osteoarthritis
5) Confidence 0.40 Published 2010 Journal J. Orthop. Res. Section Title Doc Link 19890996 Disease Relevance 0.58 Pain Relevance 0.30
Gu[12] reported a stimulatory effect in proteoglycan core protein gene expression of TGF-?
Regulation (effect) of Gene_expression (expression) of TGF
6) Confidence 0.38 Published 2006 Journal J Orthop Surg Section Body Doc Link PMC1636034 Disease Relevance 0.26 Pain Relevance 0
At the same time, however, aspirin therapy at antiplatelet doses does not change the serum levels of TGF-?
Neg (not) Regulation (change) of Gene_expression (levels) of TGF associated with aspirin
7) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842433 Disease Relevance 0.57 Pain Relevance 0.28
An altered expression of c-myc, TGF-beta1 and bax was observed in eutopic endometrium from endometriosis, suggesting its participation in the regulation of cell survival in this disease.
Regulation (altered) of Gene_expression (expression) of TGF-beta1 in endometrium associated with endometriosis and disease
8) Confidence 0.25 Published 2005 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1262771 Disease Relevance 1.06 Pain Relevance 0.29
We have found that kappa opioids exerted a time- and dose-dependent inhibitory effect on TGFbeta1 production from endometrial stromal and epithelial cells and from the Ishikawa human endometrial adenocarcinoma cell line.
Regulation (effect) of Gene_expression (production) of TGFbeta1 in epithelial cells associated with endometriosis (extended) and opioid
9) Confidence 0.25 Published 2000 Journal Mol. Hum. Reprod. Section Abstract Doc Link 10871647 Disease Relevance 0.10 Pain Relevance 0.72
We found that patient classification models built on the expression values of TGFB1 and PTEN could correctly classify 72% of these samples using a linear support vector machine classifier (SVM) and leave-one-out cross-validation (LOO).
Regulation (values) of Gene_expression (expression) of TGFB1
10) Confidence 0.21 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC2890499 Disease Relevance 0.13 Pain Relevance 0
regulates the production of growth factors including TGF- ?
Regulation (regulates) of Gene_expression (production) of TGF
11) Confidence 0.17 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 0.82 Pain Relevance 0
Alpha-MSH did not interfere with TGF-beta1 signaling, because TGF-beta1-induced expression of collagen mRNA was not affected, implying a posttranscriptional mechanism.
Neg (not) Regulation (affected) of Gene_expression (expression) of TGF-beta1-induced
12) Confidence 0.11 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14645373 Disease Relevance 0.08 Pain Relevance 0.21
However, the production of IL-10 and TGF-beta by Tregs has been challenged by others [56].
Regulation (challenged) of Gene_expression (production) of TGF-beta
13) Confidence 0.07 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2821644 Disease Relevance 0.41 Pain Relevance 0.32
Previous studies have shown that myometrial stretch also can activate focal adhesion signaling [3], [4], MAP kinase [31], [32] and regulate expression of transforming growth factor [33].
Regulation (regulate) of Gene_expression (expression) of transforming growth factor associated with adhesions
14) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0.42 Pain Relevance 0.07
In addition, the post-wound regulation of expression of these factors and of TGF-?
Regulation (regulation) of Gene_expression (expression) of TGF associated with injury
15) Confidence 0.02 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2939531 Disease Relevance 0.85 Pain Relevance 0.04
The clones were not cytolytic, but responded in an autoreactive HLA class I-restricted fashion, by proliferation and production of IL-4, IL-5, IL-13 and TGFbeta1, but not IFN-gamma.
Neg (not) Regulation (responded) of Gene_expression (production) of TGFbeta1
16) Confidence 0.01 Published 2005 Journal Eur. J. Immunol. Section Abstract Doc Link 16180249 Disease Relevance 0.13 Pain Relevance 0.10

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