INT8921

Context Info Confidence 0.36 First Reported 1992 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 0.18 Pain Relevance 0.33

plasma membrane (Trpc4) protein complex (Trpc4) transmembrane transport (Trpc4) cytoplasm (Trpc4)

Anatomy Link Frequency plasma 1 Trpc4 (Rattus norvegicus)

Pain Link Frequency Relevance Heat agonist 3 90.48 amygdala 4 85.36 Substantia nigra 4 83.92 Action potential 3 78.20 Hippocampus 24 67.04 Pyramidal cell 11 53.72 Neuronal excitability 1 51.52 Calcium channel 4 42.00 tetrodotoxin 10 36.12 sodium channel 2 33.84

Disease Link Frequency Relevance Heat Hypertrophy 1 91.00 Vibrio Infection 1 84.56 Depression 1 28.40 Urological Neuroanatomy 6 5.00 Hypersensitivity 2 5.00 Death 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The blockade of the sADP by the TRPC channel blocker, SKF96395 and the ability of the TRPC4 and 5 potentiator, La 3+ to induce the sADP in the absence of any group 1 mGluR simulation provides evidence for TRPC4 and 5 involvement in mediating the sADP.

Negative_regulation (blockade) of TRPC4

1) Confidence 0.36 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1892805 Disease Relevance 0 Pain Relevance 0.20

Second, the single-cell RT-PCR investigation demonstrated that mRNAs for many TRPC subunits are present in hcrt/orx cells and that for at least two of them, TRPC4 and 5, they are present in the vast majority (?

Negative_regulation (present) of TRPC4

2) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3002943 Disease Relevance 0 Pain Relevance 0.08

Nifedipine-induced blockade of the plasma membrane L-type calcium entry channel prevented induction of skeletal alpha-actin mRNA by isoproterenol.

Negative_regulation (blockade) of calcium entry channel in plasma

3) Confidence 0.07 Published 1992 Journal J. Biol. Chem. Section Abstract Doc Link 1383212 Disease Relevance 0.18 Pain Relevance 0.05

General Comments

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