INT89288

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Context Info
Confidence 0.40
First Reported 2000
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 4.84
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOS1) oxidoreductase activity (NOS1) cytoskeleton (NOS1)
cytoplasm (NOS1)
Anatomy Link Frequency
lung 4
coronary artery 2
muscle 2
NOS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 7 99.44 Very High Very High Very High
tetrodotoxin 6 94.48 High High
bradykinin 9 78.88 Quite High
ischemia 19 77.60 Quite High
Bioavailability 3 75.36 Quite High
Spinal cord 1 72.16 Quite High
alcohol 1 39.76 Quite Low
Inflammation 19 12.72 Low Low
Inflammatory response 1 8.04 Low Low
Migraine 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperlipidemia 4 99.84 Very High Very High Very High
Increased Venous Pressure Under Development 123 98.36 Very High Very High Very High
Coronary Artery Disease 3 97.68 Very High Very High Very High
Pneumonia 62 97.44 Very High Very High Very High
Sepsis 54 96.84 Very High Very High Very High
Hyperglycemia 2 96.68 Very High Very High Very High
Stress 11 96.44 Very High Very High Very High
Hypoxia 10 95.36 Very High Very High Very High
Glaucoma 103 94.40 High High
Reperfusion Injury 10 85.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These reports suggest that improvement of oxygenation with inhaled NO may be augmented by blockade of endogenous nitric oxide synthase (NOS) in the setting of increased NO synthesis in the lung, such as pneumonia (9) or sepsis (10).
Positive_regulation (augmented) of Negative_regulation (blockade) of NOS in lung associated with pneumonia and sepsis
1) Confidence 0.40 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721948 Disease Relevance 1.37 Pain Relevance 0
These reports suggest that improvement of oxygenation with inhaled NO may be augmented by blockade of endogenous nitric oxide synthase (NOS) in the setting of increased NO synthesis in the lung, such as pneumonia (9) or sepsis (10).
Positive_regulation (augmented) of Negative_regulation (blockade) of nitric oxide synthase in lung associated with pneumonia and sepsis
2) Confidence 0.40 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721948 Disease Relevance 1.37 Pain Relevance 0
topical formulation of the nonselective NOS inhibitor,
Positive_regulation (formulation) of Negative_regulation (inhibitor) of NOS
3) Confidence 0.34 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC555773 Disease Relevance 0.63 Pain Relevance 0.07
Plasma levels of asymmetric dimethylarginine, an endogenous inhibitor of NOS, are disproportionately elevated in hyperlipidemia, hyperhomocystinemia, atherosclerosis, coronary artery disease, hyperglycemia, and other disorders affected by endothelial dysfunction (Miyazaki et al 1999; Delaney et al 2006).
Positive_regulation (elevated) of Negative_regulation (inhibitor) of NOS in coronary artery associated with hyperglycemia, coronary artery disease, increased venous pressure under development and hyperlipidemia
4) Confidence 0.32 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699797 Disease Relevance 1.43 Pain Relevance 0.11
Blockade of nitric oxide synthase (NOS) enhanced NK1 receptor agonist evoked contractions of duodenal circular muscle, indicating that the agonists excite inhibitory motor neurones in duodenum.
Positive_regulation (enhanced) of Negative_regulation (Blockade) of nitric oxide synthase in muscle associated with agonist
5) Confidence 0.09 Published 2000 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 10886673 Disease Relevance 0 Pain Relevance 0.78
We speculate a possible mechanism of thalidomide mediated blocking of NO driven endothelial functions, which attributes, at least in part, to the thalidomide associated cytoskeleton rearrangement causing NOS inactivation.
Positive_regulation (causing) of Negative_regulation (inactivation) of NOS
6) Confidence 0.07 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1456963 Disease Relevance 0 Pain Relevance 0

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