INT89406

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Context Info
Confidence 0.22
First Reported 2000
Last Reported 2000
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 2
Disease Relevance 0.93
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRS1) signal transduction (IRS1) plasma membrane (IRS1)
nucleus (IRS1) cytoplasm (IRS1) signal transducer activity (IRS1)
Anatomy Link Frequency
muscle 2
skeletal muscle 2
IRS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 4 99.72 Very High Very High Very High
Pain 2 99.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 4 99.38 Very High Very High Very High
Insulin Resistance 8 94.92 High High
Necrosis 2 73.00 Quite High
Cancer 2 72.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, the physiological stress associated with muscle damage impairs insulin stimulation of IRS-1, PI 3-kinase, and Akt-kinase, presumably leading to decreased insulin-mediated glucose uptake.
Negative_regulation (impairs) of Positive_regulation (stimulation) of IRS-1 in muscle associated with stress
1) Confidence 0.22 Published 2000 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 10893341 Disease Relevance 0.36 Pain Relevance 0.03
Muscle damage impairs insulin stimulation of IRS-1, PI 3-kinase, and Akt-kinase in human skeletal muscle.
Negative_regulation (impairs) of Positive_regulation (stimulation) of IRS-1 in skeletal muscle associated with cytokine
2) Confidence 0.22 Published 2000 Journal Am. J. Physiol. Endocrinol. Metab. Section Title Doc Link 10893341 Disease Relevance 0.57 Pain Relevance 0.19

General Comments

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