INT89505

Context Info Confidence 0.05 First Reported 2000 Last Reported 2000 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 1.07 Pain Relevance 0.34

cytoplasm (Nos2, Ptgs2) nucleus (Nos2, Ptgs2) nuclear envelope (Ptgs2) aging (Nos2) endoplasmic reticulum (Ptgs2) peroxisome (Nos2)

Nos2 (Rattus norvegicus) Ptgs2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat qutenza 3 93.44 agonist 2 88.48 substance P 1 86.72 Inflammation 1 76.88 COX2 1 25.00

Disease Link Frequency Relevance Heat Ulcers 4 100.00 Necrosis 1 98.22 Cancer 1 98.04 Peptic Ulcer 4 90.88 Diarrhoea 2 75.00 Insect Bites And Stings 1 68.88 Gastritis 1 67.16 INFLAMMATION 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The expression of proinflammatory genes tumor necrosis factor-alpha, inducible nitric oxide synthase (iNOS), interleukin (IL)-1beta, IL-6, and cyclooxygenase-2 was upregulated by ulcer induction but reduced by sangre de grado treatment, particularly iNOS and IL-6.

iNOS Positive_regulation (upregulated) of cyclooxygenase-2 associated with necrosis, cancer and ulcers

1) Confidence 0.05 Published 2000 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 10898763 Disease Relevance 1.07 Pain Relevance 0.34

General Comments

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