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Context Info
Confidence 0.61
First Reported 2000
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 7.65
Pain Relevance 3.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl5) aging (Ccl5) extracellular region (Ccl5)
cell-cell signaling (Ccl5) cytoplasm (Ccl5)
Anatomy Link Frequency
T-cell 3
peritoneal fluid 1
macrophage 1
sciatic nerves 1
Ccl5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 88 100.00 Very High Very High Very High
Inflammatory mediators 4 100.00 Very High Very High Very High
Sciatic nerve 8 99.80 Very High Very High Very High
Inflammation 69 98.16 Very High Very High Very High
Pain 19 97.36 Very High Very High Very High
Neuritis 4 96.92 Very High Very High Very High
dorsal root ganglion 42 95.04 Very High Very High Very High
endometriosis 5 94.44 High High
Migraine 2 93.16 High High
cytokine 18 88.36 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 86 100.00 Very High Very High Very High
Necrosis 8 100.00 Very High Very High Very High
Cancer 4 100.00 Very High Very High Very High
Cirrhosis 24 99.98 Very High Very High Very High
Experimental Autoimmune Neuritis 4 97.88 Very High Very High Very High
Neurogenic Inflammation 2 97.80 Very High Very High Very High
Leukemia 2 97.78 Very High Very High Very High
Disease 15 97.72 Very High Very High Very High
Hypertension 52 97.52 Very High Very High Very High
Repression 4 97.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Regulated upon activation, normal T-cell expressed and secreted (RANTES) is a small protein and a prototype member of the CC chemokine-beta subfamily with chemoattractant and inflammatory properties.
Localization (secreted) of RANTES in T-cell associated with chemokine and inflammation
1) Confidence 0.61 Published 2006 Journal Int. J. Biol. Markers Section Abstract Doc Link 17177158 Disease Relevance 0.64 Pain Relevance 0.28
Rat basophilic leukemia cells (RBL-2H3) generate prostaglandin D2 (PGD2) after regulated upon activation, normal T-cell expressed and secreted (RANTES) activation.
Localization (secreted) of RANTES in T-cell associated with leukemia
2) Confidence 0.61 Published 2006 Journal Int. J. Biol. Markers Section Title Doc Link 17177158 Disease Relevance 0.62 Pain Relevance 0.26
We studied the effect (subchronic administration: 5 days) of HIVgp120, and a few immune-response mediators: regulated upon activation normal T-cell expressed and presumably secreted (RANTES), stromal derived factor-1alpha (SDF-1alpha), macrophage-derived chemokine (MDC), and their combination, on food and water intake in rats, motor control and pain perception.
Localization (secreted) of RANTES in macrophage associated with pain and chemokine
3) Confidence 0.52 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16343773 Disease Relevance 0.36 Pain Relevance 0.30
The apparently "negative" results on ICAM-1, VCAM-1 and RANTES should not be misinterpreted to exclude a role of these factors.
Neg (not) Localization (misinterpreted) of RANTES
4) Confidence 0.42 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 1.23 Pain Relevance 0.03
These cells may release RANTES within the perineural environment and release of TNF?
Localization (release) of RANTES
5) Confidence 0.17 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.69 Pain Relevance 0.35
In particular, HSCs secrete a broad spectrum of inflammatory mediators, (that is, chemokines, MCP-1 and RANTES).
Localization (secrete) of RANTES associated with chemokine, inflammatory mediators and cirrhosis
6) Confidence 0.14 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2637833 Disease Relevance 1.17 Pain Relevance 0.33
RANTES protein was localized immunohistologically to invading T lymphocytes.
Localization (localized) of RANTES in T lymphocytes
7) Confidence 0.07 Published 2000 Journal J. Neuroimmunol. Section Abstract Doc Link 11024541 Disease Relevance 0.59 Pain Relevance 0.57
In the present study we report the expression pattern of the chemokines interferon-gamma-inducible protein (IP)-10, monocyte chemoattractant protein (MCP)-1, macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and regulated upon activation normal T cell expressed and secreted (RANTES) in sciatic nerves from animals with myelin-induced experimental autoimmune neuritis, using a semiquantitative reverse transcriptase-PCR dot-blot hybridization assay.
Localization (secreted) of RANTES in sciatic nerves associated with chemokine, inflammation, experimental autoimmune neuritis, sciatic nerve and neuritis
8) Confidence 0.05 Published 2000 Journal J. Neuroimmunol. Section Abstract Doc Link 11024541 Disease Relevance 0.74 Pain Relevance 0.59
The same rank order was found for inhibition of RANTES release.
Localization (release) of RANTES
9) Confidence 0.05 Published 2000 Journal Am. J. Respir. Crit. Care Med. Section Abstract Doc Link 10903220 Disease Relevance 0.45 Pain Relevance 0.15
Endometriosis affects 10-20% of women during reproductive age and is a common cause of infertility and pain leading to work absenteeism and reduced quality of life.The objective of this study was to investigate the association between the presence and concentration of interleukin-8 (IL-8), RANTES, osteoprotegerin (OPG), pregnancy-associated plasma protein A (PAPP-A), tumour necrosis factor-alpha (TNF-alpha), midkine and glycodelin in the peritoneal fluid (PF) and the intensity of pain reported by patients undergoing laparoscopy in our clinic.
Localization (midkine) of RANTES in peritoneal fluid associated with pain, endometriosis, necrosis, reprotox - general 3 and cancer
10) Confidence 0.04 Published 2009 Journal Gynecol. Endocrinol. Section Abstract Doc Link 19903048 Disease Relevance 1.17 Pain Relevance 0.76

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