INT89606

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Context Info
Confidence 0.70
First Reported 2000
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 8.34
Pain Relevance 3.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ALOX15) oxidoreductase activity (ALOX15) nucleolus (ALOX15)
nucleus (ALOX15) lipid metabolic process (ALOX15) cytoplasm (ALOX15)
Anatomy Link Frequency
RKO 2
ALOX15 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 56 99.98 Very High Very High Very High
COX-2 inhibitor 1 86.08 High High
Inflammation 1 50.00 Quite Low
COX2 4 25.00 Low Low
cOX1 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Esophageal Cancer 18 99.74 Very High Very High Very High
Apoptosis 54 99.72 Very High Very High Very High
INFLAMMATION 15 99.72 Very High Very High Very High
Colon Cancer 25 99.56 Very High Very High Very High
Stomach Cancer 12 99.02 Very High Very High Very High
Cancer 7 98.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Sulindac and NS-398 progressively increased 15-LOX-1 protein expression in RKO cells (at 24, 48, and 72 hours) in association with subsequent growth inhibition and apoptosis.
Positive_regulation (increased) of Gene_expression (expression) of 15-LOX-1 in RKO
1) Confidence 0.70 Published 2000 Journal J. Natl. Cancer Inst. Section Body Doc Link 10904086 Disease Relevance 0.16 Pain Relevance 0
Cancer Inst., 92: 1136-1142, 2000) that (a) 15-lipoxygenase-1 (15-LOX-1) protein and its product 13-S-hydroxyoctadecadienoic acid (13-S-HODE) are decreased; and (b) nonsteroidal anti-inflammatory drug (NSAID)-induced 15-LOX-1 expression is critical to NSAID-induced apoptosis in colorectal cancer cells expressing cyclooxygenase-2 (COX-2).
Positive_regulation (induced) of Gene_expression (expression) of 15-LOX-1 associated with inflammation, cancer, colon cancer, cinod and apoptosis
2) Confidence 0.67 Published 2000 Journal Cancer Res. Section Abstract Doc Link 11156377 Disease Relevance 0.90 Pain Relevance 0.86
We found that: (a) 15-LOX-1 was down-regulated in human esophageal carcinomas; (b) NSAIDs induced 15-LOX-1 expression during apoptosis in esophageal cancer cells; and (c) 15-LOX-1 inhibition suppressed NSAID-induced apoptosis, which was restored by 13-S-hydroxyoctadecadienoic acid but not by its parent compound, linoleic acid.
Positive_regulation (induced) of Gene_expression (expression) of 15-LOX-1 associated with cinod, apoptosis and esophageal cancer
3) Confidence 0.61 Published 2001 Journal Cancer Res. Section Abstract Doc Link 11406566 Disease Relevance 1.70 Pain Relevance 0.68
We tested the hypothesis that NSAIDs induce apoptosis in colorectal cancer cells by increasing the protein expression and enzymatic activity of 15-LOX-1.
Positive_regulation (increasing) of Gene_expression (expression) of 15-LOX-1 associated with colon cancer, cinod and apoptosis
4) Confidence 0.50 Published 2000 Journal J. Natl. Cancer Inst. Section Abstract Doc Link 10904086 Disease Relevance 0.89 Pain Relevance 0.48
We found previously that NSAIDs induce apoptosis in these cells by restoring 15-lipoxygenase-1 (15-LOX-1) expression.
Positive_regulation (restoring) of Gene_expression (expression) of 15-LOX-1 associated with cinod and apoptosis
5) Confidence 0.49 Published 2002 Journal Cancer Res. Section Abstract Doc Link 11861401 Disease Relevance 0.69 Pain Relevance 0.83
The effects of the transient transfection of 15-LOX-1 cDNA on indomethacin-induced apoptosis were certified in HCT-116 cells.
Positive_regulation (transfection) of Gene_expression (transfection) of 15-LOX-1
6) Confidence 0.49 Published 2007 Journal J. Gastroenterol. Hepatol. Section Body Doc Link 17559385 Disease Relevance 0.25 Pain Relevance 0
We found that: (i) SC-236 inhibited growth of gastric cancer cells mainly by inducing apoptosis; (ii) SC-236 induced 15-LOX-1 expression and increased endogenous 13-S-HODE product, instead of 15-S-HETE during apoptosis; (iii) SC-236 did not affect expression of COX-1, COX-2, 5-LOX and 12-LOX; and (iv) 15-LOX-1 inhibition suppressed SC-236 induced apoptosis.
Positive_regulation (induced) of Gene_expression (expression) of 15-LOX-1 associated with apoptosis and stomach cancer
7) Confidence 0.44 Published 2003 Journal Carcinogenesis Section Abstract Doc Link 12584173 Disease Relevance 1.40 Pain Relevance 0.16
In previous studies, we have found that expression of 15-lipoxygenase-1 (15-LOX-1) and its main product, 13-S-hydroxyoctadecadienoic acid, are decreased in human colorectal cancers and that nonsteroidal anti-inflammatory drugs (NSAIDs) can therapeutically induce 15-LOX-1 expression to trigger apoptosis in human colorectal cancer cells.
Positive_regulation (induce) of Gene_expression (expression) of 15-LOX-1 associated with inflammation, colon cancer, cinod and apoptosis
8) Confidence 0.41 Published 2001 Journal Cancer Res. Section Abstract Doc Link 11406566 Disease Relevance 1.27 Pain Relevance 0.55
It has been found that expression of 15-lipoxygenase-1 (15-LOX-1) and its main product, 13-S-hydroxyoctadecadienoic acid (13-S-HODE), are decreased in human colorectal and esophageal cancers and that non-steroidal anti-inflammatory drugs (NSAIDs) can therapeutically induce 15-LOX-1 expression to trigger apoptosis in those cancer cells.
Positive_regulation (induce) of Gene_expression (expression) of 15-LOX-1 associated with inflammation, cancer, cinod, apoptosis and esophageal cancer
9) Confidence 0.30 Published 2003 Journal Carcinogenesis Section Abstract Doc Link 12584173 Disease Relevance 1.09 Pain Relevance 0.20

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