INT89691

Context Info Confidence 0.23 First Reported 2000 Last Reported 2000 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.56 Pain Relevance 0.13

cell proliferation (Brca2) chromosome organization (Brca2) nucleus (Brca2) cell cycle (Brca2) DNA binding (Brca2) protein complex (Brca2)

Brca2 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 2 64.56 Dismenorea 1 63.44 fibrosis 1 62.08

Disease Link Frequency Relevance Heat Ovarian Cancer 1 96.32 Breast Cancer 1 92.20 Hyperplasia 1 67.76 INFLAMMATION 1 64.56 Dysmenorrhea 1 63.44 Fibrosis 1 62.08 Hypertrophy 1 58.48 Sprains And Strains 3 54.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We used mice with a Brca1 mutation on a BALB/cJ inbred background (BALB/cB1+/- mice) or a Brca2 genetic alteration on the 129/SvEv genetic background (129B2+/- mice) to investigate potential gene-environment interactions between defects in these genes and treatment with the highly estrogenic compound diethylstilbestrol (DES).

Regulation (alteration) of Brca2

1) Confidence 0.23 Published 2000 Journal Cancer Res. Section Abstract Doc Link 10910057 Disease Relevance 0.56 Pain Relevance 0.13

General Comments

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