INT89765

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Context Info
Confidence 0.69
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 8.13
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NR4A1) signal transduction (NR4A1) nucleus (NR4A1)
DNA binding (NR4A1)
Anatomy Link Frequency
colon 3
uterus 1
Caco-2 1
NR4A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 4 97.24 Very High Very High Very High
cINOD 20 96.80 Very High Very High Very High
Inflammation 8 87.28 High High
Paracetamol 1 73.60 Quite High
cytokine 1 66.96 Quite High
calcitonin gene related peptide 1 18.80 Low Low
medulla 1 18.04 Low Low
aspirin 5 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 99 99.98 Very High Very High Very High
Rheumatoid Arthritis 29 99.70 Very High Very High Very High
Apoptosis 62 99.36 Very High Very High Very High
Colon Cancer 68 98.16 Very High Very High Very High
Cv Unclassified Under Development 4 97.24 Very High Very High Very High
INFLAMMATION 17 96.60 Very High Very High Very High
Cancer 195 95.28 Very High Very High Very High
Aggression 3 89.84 High High
Prostate Cancer 55 87.88 High High
Adhesions 21 86.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among the two potential trans-acting factors that activate Nur77-promoter, indomethacin induced DNA binding and reporter gene activity of AP-1, but not that of related serum response factor (RSRF), suggesting that the transcriptional induction of Nur77 may be mediated through activation of AP-I.
Positive_regulation (activate) of Nur77-promoter
1) Confidence 0.69 Published 2000 Journal Biol. Pharm. Bull. Section Abstract Doc Link 10919358 Disease Relevance 0.88 Pain Relevance 0.16
Among the two potential trans-acting factors that activate Nur77-promoter, indomethacin induced DNA binding and reporter gene activity of AP-1, but not that of related serum response factor (RSRF), suggesting that the transcriptional induction of Nur77 may be mediated through activation of AP-I.
Positive_regulation (induction) of Nur77
2) Confidence 0.69 Published 2000 Journal Biol. Pharm. Bull. Section Abstract Doc Link 10919358 Disease Relevance 0.86 Pain Relevance 0.14
Transcriptional induction of Nur77 by indomethacin that results in apoptosis of colon cancer cells.
Positive_regulation (induction) of Nur77 in colon associated with colon cancer and apoptosis
3) Confidence 0.69 Published 2000 Journal Biol. Pharm. Bull. Section Title Doc Link 10919358 Disease Relevance 0.95 Pain Relevance 0.19
Further, we showed that all trans-RA repressed the induction of Nur77 as well as the apoptosis-induced by indomethacin, providing evidence that transcriptional induction of Nur77 may be an important mechanism by which indomethacin induces apoptosis in colon cancer cells.
Positive_regulation (induction) of Nur77 in colon associated with colon cancer, rheumatoid arthritis and apoptosis
4) Confidence 0.69 Published 2000 Journal Biol. Pharm. Bull. Section Abstract Doc Link 10919358 Disease Relevance 1.01 Pain Relevance 0.12
Further, we showed that all trans-RA repressed the induction of Nur77 as well as the apoptosis-induced by indomethacin, providing evidence that transcriptional induction of Nur77 may be an important mechanism by which indomethacin induces apoptosis in colon cancer cells.
Positive_regulation (induction) of Nur77 in colon associated with colon cancer, rheumatoid arthritis and apoptosis
5) Confidence 0.60 Published 2000 Journal Biol. Pharm. Bull. Section Abstract Doc Link 10919358 Disease Relevance 1.03 Pain Relevance 0.13
The transcript- and protein-level, the transcriptional activity of Nur77 promoter, and the DNA binding of Nur77 were significantly induced following indomethacin treatment.
Positive_regulation (induced) of Nur77
6) Confidence 0.50 Published 2000 Journal Biol. Pharm. Bull. Section Abstract Doc Link 10919358 Disease Relevance 0.91 Pain Relevance 0.17
Since the n10 is a negative potential, it indicates excitation
Positive_regulation (negative) of n10
7) Confidence 0.32 Published 2010 Journal Acta Otorhinolaryngologica Italica Section Body Doc Link PMC3008154 Disease Relevance 0.08 Pain Relevance 0
This gene list includes DUSP1, BTG2, IER2, PTGS2, NR4A1, AMD1, C20orf35, KLF4, RAB4A, KLF6, CTGF and GOLPH2.
Positive_regulation (includes) of NR4A1
8) Confidence 0.31 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1865555 Disease Relevance 0.94 Pain Relevance 0.17
Using Northern blot RNA analysis Cicatiello et al [37] reported that NR4A1 was transiently activated in the uterus (up to 20-fold) within 30–120 min after treatment of adult ovariectomized rats with estrogen.
Positive_regulation (activated) of NR4A1 in uterus
9) Confidence 0.24 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 0.32 Pain Relevance 0.03
In Caco-2 cells several transcription factors were upregulated by curcumin, like NR2F1, NR4A1 and MTF1, whereas transcription factor FOSB and transcription-related genes HNRPA0 and POLR1C were downregulated (Table 3).
Positive_regulation (upregulated) of NR4A1 in Caco-2
10) Confidence 0.20 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0 Pain Relevance 0
activates the nuclear hormone receptor nuclear receptor subfamily 1, group D, member 2 (NR1D2), blocking signaling from the orphan receptor-?
Positive_regulation (activates) of nuclear hormone receptor nuclear receptor subfamily 1
11) Confidence 0.15 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2290973 Disease Relevance 0.26 Pain Relevance 0.12
Hence, this seminal paper identified specific subtypes of breast tumours based upon hormone receptor and HER2 status.
Positive_regulation (based) of upon hormone receptor associated with breast cancer
12) Confidence 0.03 Published 2006 Journal Proteome Sci Section Body Doc Link PMC1456950 Disease Relevance 0.88 Pain Relevance 0

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