INT89834

Context Info Confidence 0.49 First Reported 2000 Last Reported 2010 Negated 1 Speculated 1 Reported most in Body Documents 8 Total Number 9 Disease Relevance 1.89 Pain Relevance 2.77

transmembrane transport (SCN2A)

Anatomy Link Frequency plasma 1 SCN2A (Homo sapiens)

Pain Link Frequency Relevance Heat Nav1.1 8 100.00 Nav1.2 6 100.00 sodium channel 15 99.96 tetrodotoxin 13 99.44 nav1.3 7 98.16 lidocaine 1 96.00 Nav1.6 7 95.76 Nav1.7 7 94.40 Nerve growth factor 1 92.28 Root ganglion neuron 2 92.12

Disease Link Frequency Relevance Heat Diabetes Mellitus 15 99.60 Cognitive Disorder 2 98.48 Repression 1 97.92 Hyperglycemia 2 95.20 Disease 1 94.72 Epilepsy 2 93.88 Febrile Convulsions 1 92.64 Convulsion 1 91.92 Ganglion Cysts 2 91.80 Pain 5 89.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the presence of REST, the CoREST/HDAC2 complex occupied the native Nav1.2 sodium channel gene in chromatin.

Positive_regulation (occupied) of Nav1.2 associated with sodium channel and nav1.2

1) Confidence 0.49 Published 2001 Journal Neuron Section Abstract Doc Link 11516394 Disease Relevance 0.10 Pain Relevance 0.24

Both Na(V)1.2 and Na(V)1.6 were strongly blocked; within experimental wash times of 40-60 min, block was reversed very little for Na(V)1.2 and only partially for Na(V)1.6.

Neg (little) Spec (partially) Positive_regulation (little) of Na(V)1.2

2) Confidence 0.49 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17724025 Disease Relevance 0.26 Pain Relevance 1.07

subunits are inhibited by TTX in the nanomolar range and include SCN1A (also known as Nav1.1), SCN2A (also known as Nav1.2), SCN3A (also known as Nav1.3), SCN4A (also known as Nav1.4), SCN8A (also known as Nav1.6), and SCN9A (also known as Nav1.7).

Positive_regulation (include) of SCN2A associated with nav1.3, tetrodotoxin, nav1.1, nav1.2, nav1.7 and nav1.6

3) Confidence 0.48 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724540 Disease Relevance 0 Pain Relevance 1.27

"Cognitive functioning" was the only HRQoL scale on which diabetic subjects with high levels of HbA(1c) (HbA(1c)>7.0%) scored worse than those with acceptable levels (HbA(1c)<7.0%).

Positive_regulation (levels) of HbA associated with cognitive disorder and diabetes mellitus

4) Confidence 0.45 Published 2000 Journal J. Diabetes Complicat. Section Abstract Doc Link 10925063 Disease Relevance 0.89 Pain Relevance 0.09

METHODS AND RESULTS: We compared HbA(1c) (percentage) and the time to onset of a > or =1% increase in HbA(1c) among 4918 patients with acute coronary syndrome randomized to ranolazine or placebo in the MERLIN-TIMI 36 trial.

Positive_regulation (increase) of HbA

5) Confidence 0.45 Published 2009 Journal Circulation Section Body Doc Link 19349325 Disease Relevance 0.10 Pain Relevance 0

METHODS AND RESULTS: We compared HbA(1c) (percentage) and the time to onset of a > or =1% increase in HbA(1c) among 4918 patients with acute coronary syndrome randomized to ranolazine or placebo in the MERLIN-TIMI 36 trial.

Positive_regulation (increase) of HbA

6) Confidence 0.45 Published 2009 Journal Circulation Section Body Doc Link 19349325 Disease Relevance 0.09 Pain Relevance 0

We screened SCN2A for mutations and carried out in vitro electrophysiologic analyses to study the consequences of the identified mutation.

Positive_regulation (screened) of SCN2A

7) Confidence 0.40 Published 2010 Journal Neurology Section Body Doc Link 20956790 Disease Relevance 0.28 Pain Relevance 0

OGTT was often elevated, whereas both fasting plasma glucose and HbA(1c) were normal.

Positive_regulation (elevated) of HbA in plasma

8) Confidence 0.20 Published 2001 Journal Diabetes Care Section Body Doc Link 11473085 Disease Relevance 0.17 Pain Relevance 0

At the end of a ramp to -20 mV, a sudden repolarization to approximately -35 mV fully deactivated I(Na2).

Positive_regulation (deactivated) of Na2

9) Confidence 0.05 Published 2008 Journal Exp. Physiol. Section Abstract Doc Link 17993508 Disease Relevance 0 Pain Relevance 0.10

General Comments

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