INT89842

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Context Info
Confidence 0.69
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 34
Total Number 35
Disease Relevance 9.57
Pain Relevance 13.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Src) enzyme binding (Src) response to stress (Src)
cytoplasm (Src) cytosol (Src) cell proliferation (Src)
Anatomy Link Frequency
spinal cord 5
neurons 4
urethra 4
tails 1
external 1
Src (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 613 100.00 Very High Very High Very High
Opioid 11 100.00 Very High Very High Very High
Delta opioid receptors 2 100.00 Very High Very High Very High
Spinal cord 474 99.68 Very High Very High Very High
Hippocampus 103 99.68 Very High Very High Very High
Enkephalin 4 99.34 Very High Very High Very High
intrathecal 249 99.32 Very High Very High Very High
Lasting pain 105 99.30 Very High Very High Very High
MU agonist 3 99.20 Very High Very High Very High
opioid receptor 18 99.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 3 99.60 Very High Very High Very High
Stress 4 99.44 Very High Very High Very High
Stress Incontinence 25 99.38 Very High Very High Very High
Pain 203 99.30 Very High Very High Very High
Bordatella Infection 2 98.58 Very High Very High Very High
Inflammatory Pain 105 98.04 Very High Very High Very High
Low Back Pain 5 97.44 Very High Very High Very High
Hyperalgesia 429 96.20 Very High Very High Very High
Hypersensitivity 1 95.68 Very High Very High Very High
Nociception 216 94.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phosphorylation of a subunit of N-methyl-D-aspartate (NMDA) receptor by protein tyrosine kinase (PTK) Src or Trk is known to enhance its channel activity.
Phosphorylation (Phosphorylation) of Src
1) Confidence 0.69 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12754057 Disease Relevance 0.53 Pain Relevance 0.50
Interestingly, PDGF-BB treatment increased the phosphorylation of Src at both tyrosine 416 (tyrosine phosphorylation here potentiates Src activity) and 527 (tyrosine phosphorylation inhibits Src activity) [39].
Phosphorylation (phosphorylation) of Src
2) Confidence 0.46 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0 Pain Relevance 0.11
The increases in tyrosine phosphorylation at both the inhibitory and activation tyrosine residues of Src in the hippocampus suggest the intriguing possibility that two or more pools of Src may be present in neurons as well.
Phosphorylation (phosphorylation) of Src in neurons associated with hippocampus
3) Confidence 0.46 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0 Pain Relevance 0.35
Activation of Src kinase via the phosphorylation of tyrosine 416 is associated with a potentiation of NMDA receptor currents and an increase in long-term potentiation [40-42].
Phosphorylation (phosphorylation) of Src associated with nmda receptor and long-term potentiation
4) Confidence 0.45 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0 Pain Relevance 0.15
Interestingly, PDGF-BB treatment increased the phosphorylation of Src at both tyrosine 416 (tyrosine phosphorylation here potentiates Src activity) and 527 (tyrosine phosphorylation inhibits Src activity) [39].
Phosphorylation (phosphorylation) of Src
5) Confidence 0.45 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0 Pain Relevance 0.14
Interestingly, PDGF-BB treatment increased the phosphorylation of Src at both tyrosine 416 (tyrosine phosphorylation here potentiates Src activity) and 527 (tyrosine phosphorylation inhibits Src activity) [39].
Phosphorylation (phosphorylation) of Src
6) Confidence 0.45 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0 Pain Relevance 0.14
Interestingly, Takasu et al. (2002) showed that in primary cortical neurons in culture EphB activation by ephrinB2-Fc (immunoglobulin Fc fusion protein of ephrinB2) induced Src-dependent NR2B phosphorylation and furthermore we showed that intrathecal injection of ephrinB2-Fc induces Src phosphorylation in the spinal cord of adult rats (Battaglia et al., 2003).
Phosphorylation (phosphorylation) of Src in spinal cord associated with spinal cord and intrathecal
7) Confidence 0.40 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.34 Pain Relevance 0.66
Src phosphorylation is required for phosphorylation of the NR2B subunit of the NMDA receptor and for induction of thermal hyperalgesia by ephrinB2.
Phosphorylation (phosphorylation) of Src associated with thermal hyperalgesia and nmda receptor
8) Confidence 0.40 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.97 Pain Relevance 0.92
Takasu et al. (2002), working with cultured embryonic cortical neurons, established that EphB receptor activation in these neurons, obtained with treatment with ephrinB2-Fc chimeras, induced Src family kinases phosphorylation at residue Tyr416, with consequent NR2B receptor phosphorylation and increased Ca2+ influx through NMDA receptors upon glutamate administration.
Phosphorylation (phosphorylation) of Src in neurons associated with glutamate and nmda receptor
9) Confidence 0.40 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.18 Pain Relevance 0.25
Pertussis toxin has no effect on the level of STAT5A phosphorylation, while the Src inhibitor PP1 abolishes opioid-dependent STAT5A phosphorylation.
Phosphorylation (phosphorylation) of Src associated with bordatella infection and opioid
10) Confidence 0.39 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15857395 Disease Relevance 0.10 Pain Relevance 0.64
Results were expressed as the level of phosphorylation for each sample i.e. as the ratio (in arbitrary units) of the phosphorylated form (phospho-tyrosine-NR2B/phospho-Src/phospho-Ser1303/phospho-Tyr1472) over total form of NR2B.


Phosphorylation (phosphorylation) of phospho-Src
11) Confidence 0.39 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.05 Pain Relevance 0.08
Intrathecally administered ephrinB2 induces NR2B phosphorylation via Src
Phosphorylation (phosphorylation) of Src
12) Confidence 0.30 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.17 Pain Relevance 0.28
We therefore formulated the hypothesis that EphB receptors are involved in synaptic plasticity in vivo in the spinal cord (underlying chronic pain states) via a mechanism involving Src activation and NR2B phosphorylation.
Phosphorylation (phosphorylation) of Src in spinal cord associated with lasting pain and spinal cord
13) Confidence 0.30 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.48 Pain Relevance 0.77
Phosphorylation levels of Src-family kinases bound to NR2B were significantly elevated following ephrinB2-Fc application onto the dorsal horn (Fig. 2A).
Phosphorylation (Phosphorylation) of Src in dorsal horn associated with dorsal horn
14) Confidence 0.30 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.14 Pain Relevance 0.25
Our findings (Battaglia et al., 2003, and present work) support the idea of an activation by ephrinB2 of postsynaptic EphB receptors in neurons of the dorsal horn, since we showed that EphB1 receptors are present in dorsal horn neurons, where they are found in close association with NMDA receptors, and intrathecal administration of ephrinB2-Fc induces an increase in phosphorylated Src kinase associated with the EphB receptor itself.
Phosphorylation (phosphorylated) of Src in neurons associated with nmda receptor, dorsal horn, dorsal horn neuron and intrathecal
15) Confidence 0.30 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 1.01 Pain Relevance 0.93
Interestingly, Takasu et al. (2002) showed that in primary cortical neurons in culture EphB activation by ephrinB2-Fc (immunoglobulin Fc fusion protein of ephrinB2) induced Src-dependent NR2B phosphorylation and furthermore we showed that intrathecal injection of ephrinB2-Fc induces Src phosphorylation in the spinal cord of adult rats (Battaglia et al., 2003).
Phosphorylation (phosphorylation) of Src in spinal cord associated with spinal cord and intrathecal
16) Confidence 0.30 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.32 Pain Relevance 0.57
In the present study we provide more direct evidence supporting the hypothesis of a role of EphB receptors in physiological synaptic plasticity in vivo, via modulation of NMDA receptor activity, and in particular via Src-mediated phosphorylation of the NR2B subunit.
Phosphorylation (phosphorylation) of Src associated with nmda receptor
17) Confidence 0.30 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.60 Pain Relevance 0.97
Evidence exists for a role at least of Fyn and Src in NMDA receptor phosphorylation (Salter and Kalia, 2004), therefore we cannot exclude that a combination of at least these two Src family kinases is responsible for ephrinB2-mediated NR2B phosphorylation in our spinal cord plasticity model.
Phosphorylation (phosphorylation) of Src in spinal cord associated with nmda receptor and spinal cord
18) Confidence 0.30 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.21 Pain Relevance 0.32
Indeed, EphB2 activation of Src by phosphorylation in cultured hippocampal and cortical neurons could induce NR2A phosphorylation (Grunwald et al., 2001).
Phosphorylation (phosphorylation) of Src in neurons
19) Confidence 0.30 Published 2008 Journal Neuroscience Section Body Doc Link PMC2568875 Disease Relevance 0.15 Pain Relevance 0.32
NR2 is tyrosine phosphorylated at its C-terminal tails by Src-family tyrosine kinases, such as Src, Fyn [28,29].
Phosphorylation (phosphorylated) of Src in tails
20) Confidence 0.29 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.63 Pain Relevance 1.13

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