INT89938

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Context Info
Confidence 0.25
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 1.30
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4, TNF) plasma membrane (Tlr4, TNF) intracellular (Tlr4, TNF)
extracellular space (TNF) extracellular region (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
macrophages 6
brain 2
Kupffer cells 2
Tlr4 (Mus musculus)
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 74 100.00 Very High Very High Very High
cytokine 63 100.00 Very High Very High Very High
adenocard 4 99.76 Very High Very High Very High
Inflammatory response 13 90.28 High High
Analgesic 2 82.64 Quite High
IPN 1 81.88 Quite High
Intracerebroventricular 1 79.00 Quite High
cINOD 2 58.28 Quite High
agonist 16 54.40 Quite High
Cannabinoid receptor 6 50.00 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 74 100.00 Very High Very High Very High
Necrosis 10 100.00 Very High Very High Very High
Cancer 10 100.00 Very High Very High Very High
Death 5 98.16 Very High Very High Very High
Shock 19 97.96 Very High Very High Very High
Inflammatory Pain 1 81.88 Quite High
Pneumonia 24 51.80 Quite High
Peptic Ulcer 1 47.28 Quite Low
Injury 7 37.84 Quite Low
Mycobacterial Infection 3 21.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lps induces IL-6 in the brain and in serum largely through TNF production.
Lps Positive_regulation (induces) of Gene_expression (production) of TNF in brain
1) Confidence 0.25 Published 2000 Journal Cytokine Section Title Doc Link 10930297 Disease Relevance 0.06 Pain Relevance 0.10
Published data on the contribution of CD14 to R-LPS- induced cytokine release are inconsistent: CD14 has been reported to be irrelevant for R-LPS-induced TNF production [14], whereas other investigations found that CD14 augmented R-LPS-induced cytokine secretion by macrophages [12], [21] as well as plasma TNF levels triggered by intravenous R-LPS [12].
LPS Spec (investigations) Positive_regulation (induced) of Gene_expression (production) of TNF in macrophages associated with cytokine
2) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855719 Disease Relevance 0.14 Pain Relevance 0.22
Thus, we could attribute the higher response of LPS-induced elevation of IL-10 and suppression of TNF in serum from GF mice to the ability of Kupffer cells in IL-10 production.
LPS Positive_regulation (elevation) of Gene_expression (suppression) of TNF in Kupffer cells
3) Confidence 0.06 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2243250 Disease Relevance 0 Pain Relevance 0.10
Previous studies have demonstrated that LPS treatment of macrophages can induce a concomitant increase in TNF synthesis and PGE2 production, and that LPS-induced TNF production by macrophages is suppressed by submicromolar concentrations of exogenous PGE2 [14, 15].
LPS Positive_regulation (induced) of Gene_expression (production) of TNF in macrophages
4) Confidence 0.06 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2243250 Disease Relevance 0 Pain Relevance 0
LPS is well known to induce production of proinflammatory mediators such as nitric oxide (NO) and cytokines including tumor necrosis factor-?
LPS Positive_regulation (induce) of Gene_expression (production) of tumor necrosis factor associated with necrosis, cancer and cytokine
5) Confidence 0.01 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872229 Disease Relevance 0.56 Pain Relevance 0.16
LPS induced an increase in TNF (17 kD [monomer] and 34 kD [dimer]) expression at the 60 min incubation time point compared to the medium control (34 kD = 1.15 ± 0.03, and 17 kD = 1.43 ± 0.03 of medium control group, p < 0.05, Figures 2A, D and 2E).
LPS Positive_regulation (increase) of Gene_expression (expression) of TNF
6) Confidence 0.01 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704199 Disease Relevance 0.10 Pain Relevance 0.05
In contrast, adenosine attenuated LPS-induced production of the pro-inflammatory cytokines TNF [58-61] and IL-12 [60,62] in mouse and human macrophages.
LPS Positive_regulation (induced) of Gene_expression (production) of TNF in macrophages associated with adenocard, inflammation and cytokine
7) Confidence 0.01 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.45 Pain Relevance 0.51

General Comments

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