INT89966

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Context Info
Confidence 0.58
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 26
Total Number 28
Disease Relevance 24.83
Pain Relevance 3.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fas) extracellular region (Fas) plasma membrane (Fas)
nucleus (Fas) cytoplasm (Fas)
Anatomy Link Frequency
liver 4
T cells 4
brain 2
Mouse 2
poly 2
Fas (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 18 99.82 Very High Very High Very High
cerebral cortex 2 99.68 Very High Very High Very High
opioid receptor 6 97.64 Very High Very High Very High
Inflammation 119 97.20 Very High Very High Very High
fibrosis 14 96.84 Very High Very High Very High
Opioid 10 95.40 Very High Very High Very High
Morphine 3 94.00 High High
Endogenous opioid 2 89.64 High High
cytokine 102 89.00 High High
Chronic pancreatitis 6 87.96 High High
Disease Link Frequency Relevance Heat
Apoptosis 916 100.00 Very High Very High Very High
Ulcers 4 100.00 Very High Very High Very High
Lymphadenopathy 42 99.96 Very High Very High Very High
Death 325 99.20 Very High Very High Very High
Sprains And Strains 30 99.16 Very High Very High Very High
Hepatitis 16 98.96 Very High Very High Very High
Injury 117 98.84 Very High Very High Very High
Cerebral Toxoplasmosis 6 98.80 Very High Very High Very High
Parkinson's Disease 4 98.72 Very High Very High Very High
Infection 172 98.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In Balb/c mice, dosing with ISIS 22023 reduced Fas mRNA and protein expressions in liver by 90%.
Negative_regulation (reduced) of Fas in liver
1) Confidence 0.58 Published 2000 Journal Nat. Biotechnol. Section Abstract Doc Link 10932156 Disease Relevance 0.73 Pain Relevance 0.06
Deregulation of Fas/FasL leads to various severe clinical disorders associated with uncontrolled T cell proliferation, such as organ transplantation graft rejection, systemic lupus erythematosus, Sjogren's syndrome, and lymphoid tumors [37].
Negative_regulation (Deregulation) of Fas/FasL in T cell associated with cancer, syndrome, organ transplantation, systemic lupus erythematosus and graft vs host disease
2) Confidence 0.56 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440798 Disease Relevance 1.18 Pain Relevance 0
In conclusion, opioid receptor blockade improves the resistance of mice to Fas-induced hepatitis via a peripheral mechanism that does not involve a down-modulation of Fas mRNA in hepatocytes nor a decrease in proinflammatory activity of neutrophils.
Negative_regulation (down-modulation) of Fas in neutrophils associated with opioid receptor and hepatitis
3) Confidence 0.50 Published 2004 Journal Hepatology Section Abstract Doc Link 15389866 Disease Relevance 0.52 Pain Relevance 0.78
Western blotting showed that a single injection of naltrexone (1 mg/kg) induced a down-regulation of the pro-apototic proteins Fas, FasL, Bad and Bax.
Negative_regulation (down-regulation) of Fas
4) Confidence 0.47 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16716514 Disease Relevance 0.24 Pain Relevance 0.27
Acetaminophen-induced inhibition of Fas receptor-mediated liver cell apoptosis: mitochondrial dysfunction versus glutathione depletion.
Negative_regulation (inhibition) of Fas receptor in liver associated with parkinson's disease, paracetamol and apoptosis
5) Confidence 0.43 Published 2002 Journal Toxicol. Appl. Pharmacol. Section Title Doc Link 12051997 Disease Relevance 0.75 Pain Relevance 0.62
Mouse Fas-Fc- a competitive inhibitor of Fas-Fas-L interactions effectively inhibited apoptosis in the lymphomas studied confirming the involvement of the Fas-Fas-L pathway in apoptosis induced by bacterial Sags.
Negative_regulation (inhibitor) of Fas in Mouse associated with lymphatic system cancer and apoptosis
6) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 1.11 Pain Relevance 0
Combined loss of Fas and Bim also synergized in causing lymphadenopathy, demonstrating that these two pathways cooperate not only in the killing of T cells chronically activated by pathogen-borne antigens but also those stimulated by self-antigens.
Negative_regulation (loss) of Fas in T cells associated with lymphadenopathy
7) Confidence 0.42 Published 2008 Journal Immunity Section Body Doc Link PMC2270348 Disease Relevance 0.43 Pain Relevance 0.04
Loss of either Bim or Fas both lead to marked lymphadenopathy.
Negative_regulation (Loss) of Fas associated with lymphadenopathy
8) Confidence 0.42 Published 2008 Journal Immunity Section Body Doc Link PMC2270348 Disease Relevance 0.91 Pain Relevance 0
Some studies showed that deletion of SEB-activated T cells in mice was in part FasL-Fas dependent (Mogil et al., 1995; Renno et al., 1996), whereas others found that Fas deficiency (in Faslpr/lpr mutant mice) had no impact but that loss of Bim provided profound protection (Hildeman et al., 2002).
Negative_regulation (deficiency) of Fas in T cells
9) Confidence 0.42 Published 2008 Journal Immunity Section Body Doc Link PMC2270348 Disease Relevance 0.30 Pain Relevance 0
An analogue of viral double-stranded RNA, polyinosinic:polycytidylic acid (poly I:C), which is recognized by TLR3, was injected into autoimmune-prone strains: MRL/Mp mice (MRL/+), MRL/Mp mice with a deficit of Fas (MRL/lpr) and MRL/Mp mice with a deficit of functional FasL (MRL/gld).
Negative_regulation (deficit) of lpr in poly associated with sprains and strains
10) Confidence 0.41 Published 2009 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 19282652 Disease Relevance 0.44 Pain Relevance 0.16
An analogue of viral double-stranded RNA, polyinosinic:polycytidylic acid (poly I:C), which is recognized by TLR3, was injected into autoimmune-prone strains: MRL/Mp mice (MRL/+), MRL/Mp mice with a deficit of Fas (MRL/lpr) and MRL/Mp mice with a deficit of functional FasL (MRL/gld).
Negative_regulation (deficit) of Fas in poly associated with sprains and strains
11) Confidence 0.41 Published 2009 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 19282652 Disease Relevance 0.44 Pain Relevance 0.16
Upregulation of Bcl-2 and downregulation of Fas in injured fB-/- brains
Negative_regulation (downregulation) of Fas in brains
12) Confidence 0.39 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1540436 Disease Relevance 0.99 Pain Relevance 0.09
When present on the MRL genetic background, the loss of FAS-mediated apoptosis results in massive lymphoproliferation with expansion of the B220+CD3+CD4-CD8- cell population and the generation of autoreactive T cells [34].
Negative_regulation (loss) of FAS-mediated in T cells associated with apoptosis
13) Confidence 0.39 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 1.37 Pain Relevance 0.09
In mu-KO mice, but not in delta- or kappa-KO mice, the basal immunodensity of native Fas (35 kDa monomeric form) was decreased in the cerebral cortex (33%) when compared with WT littermates.
Negative_regulation (decreased) of Fas in cerebral cortex associated with cerebral cortex
14) Confidence 0.36 Published 2007 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 17030115 Disease Relevance 0.30 Pain Relevance 0.58
Mouse Fas-Fc- a competitive inhibitor of Fas-Fas-L interactions effectively inhibited apoptosis in the lymphomas studied confirming the involvement of the Fas-Fas-L pathway in apoptosis induced by bacterial Sags.
Negative_regulation (inhibitor) of Fas-Fc in Mouse associated with lymphatic system cancer and apoptosis
15) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 1.12 Pain Relevance 0
Finally, mouse Fas-Fc protein was used as a competitive inhibitor of Fas/Fas-L interactions [36].
Negative_regulation (inhibitor) of Fas
16) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 0.70 Pain Relevance 0
Furthermore, a strong upregulation of the anti-apoptotic mediator Bcl-2 and downregulation of the pro-apoptotic Fas receptor was detected in brain homogenates of head-injured fB-/- vs. fB+/+ mice by Western blot analysis.


Negative_regulation (downregulation) of Fas in brain associated with apoptosis
17) Confidence 0.29 Published 2006 Journal BMC Neurosci Section Abstract Doc Link PMC1540436 Disease Relevance 0.99 Pain Relevance 0.03
However, at 24 hours, Fas mRNA levels were significantly suppressed in the treatment group, reaching similar low levels as the sham controls (P < 0.05, mAb1379 vs.
Negative_regulation (suppressed) of Fas mRNA associated with apoptosis
18) Confidence 0.28 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC1867808 Disease Relevance 0.92 Pain Relevance 0
To test this, lpr mice and gld mice which have defective Fas and FasL expressions respectively, were used [32,47].
Negative_regulation (defective) of Fas
19) Confidence 0.25 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2995786 Disease Relevance 1.86 Pain Relevance 0.14
Fas-L expression of macrophages and T cells may induce apoptosis and contribute to ulcer formation in Fas-expressing keratinocytes during L. major infection.


Negative_regulation (ulcer) of Fas in keratinocytes associated with ulcers, apoptosis and infection
20) Confidence 0.25 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2995786 Disease Relevance 1.38 Pain Relevance 0

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