INT90044

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Context Info
Confidence 0.22
First Reported 2000
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.32
Pain Relevance 1.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 1
P9Ehs1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 8 98.88 Very High Very High Very High
opioid receptor 14 98.72 Very High Very High Very High
antinociception 2 97.64 Very High Very High Very High
medulla 1 96.92 Very High Very High Very High
antagonist 3 96.76 Very High Very High Very High
Cannabinoid receptor 1 96.54 Very High Very High Very High
Enkephalin 1 94.72 High High
Cannabinoid 1 90.72 High High
Intracerebroventricular 1 90.64 High High
tail-flick 1 85.68 High High
Disease Link Frequency Relevance Heat
Diabetes Mellitus-type I 2 96.00 Very High Very High Very High
Ocular Hypertension 70 95.96 Very High Very High Very High
Diabetes Mellitus 7 88.56 High High
Hyperglycemia 1 87.24 High High
Obesity 1 81.88 Quite High
Bordatella Infection 2 75.00 Quite High
Targeted Disruption 5 73.76 Quite High
Ganglion Cysts 28 50.00 Quite Low
Open-angle Glaucoma 1 12.68 Low Low
Glaucoma 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This suggests that a G-protein defect in signaling cannot account for the hyporesponsiveness of antinociception in this genetic model of IDDM.
Negative_regulation (defect) of G-protein associated with antinociception and diabetes mellitus-type i
1) Confidence 0.22 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10936496 Disease Relevance 0.91 Pain Relevance 0.67
This MOR-induced inhibition of IPSCs was presynaptically mediated, because MOR agonist invariably decreased IPSC amplitudes when postsynaptic G-protein was inactivated, significantly increased the paired-pulse ratio of the IPSCs, and decreased the frequency but not the amplitude of miniature IPSCs.
Negative_regulation (inactivated) of G-protein associated with agonist and opioid receptor
2) Confidence 0.03 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17804632 Disease Relevance 0.07 Pain Relevance 0.65
Because TM and CM are smooth muscle-like, we hypothesized that regulator of G-protein signaling 2 (RGS2), a regulatory protein that promotes vascular smooth muscle relaxation and blood pressure homeostasis [12-15], might control IOP.
Negative_regulation (regulator) of G-protein in blood associated with ocular hypertension
3) Confidence 0.02 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2650719 Disease Relevance 0.19 Pain Relevance 0.07
The CB(1) cannabinoid receptor antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide hydrochloride (SR141716) has been shown by many investigators to inhibit basal G-protein activity, i.e., to display inverse agonism at high concentrations.
Spec (investigators) Negative_regulation (inhibit) of G-protein associated with cannabinoid receptor and antagonist
4) Confidence 0.01 Published 2009 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19448142 Disease Relevance 0.14 Pain Relevance 0.36

General Comments

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