INT9012

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Context Info
Confidence 0.81
First Reported 1980
Last Reported 2011
Negated 1
Speculated 7
Reported most in Abstract
Documents 283
Total Number 290
Disease Relevance 31.71
Pain Relevance 106.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Vip)
Anatomy Link Frequency
nerves 14
neurons 13
muscle 9
pituitary 9
ileum 7
Vip (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neurotransmitter 521 100.00 Very High Very High Very High
substance P 374 100.00 Very High Very High Very High
Somatostatin 323 100.00 Very High Very High Very High
gABA 307 100.00 Very High Very High Very High
Neuropeptide 249 100.00 Very High Very High Very High
Glutamate 213 100.00 Very High Very High Very High
Enkephalin 209 100.00 Very High Very High Very High
Calcitonin gene-related peptide 162 100.00 Very High Very High Very High
qutenza 116 100.00 Very High Very High Very High
Dopamine 97 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Obesity 47 100.00 Very High Very High Very High
Pressure And Volume Under Development 13 100.00 Very High Very High Very High
Cancer 154 99.96 Very High Very High Very High
Syndrome 13 99.90 Very High Very High Very High
Aging 21 99.76 Very High Very High Very High
Carcinoid 32 99.72 Very High Very High Very High
Diarrhoea 28 99.66 Very High Very High Very High
Diabetes Mellitus 108 99.64 Very High Very High Very High
Vipoma 5 99.64 Very High Very High Very High
Headache 14 99.54 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Met]enkephalin and TTX inhibited basal VIP release by 43 +/- 8% (P less than .001) and 65 +/- 13% (P less than .01), respectively.
Localization (release) of VIP associated with tetrodotoxin and enkephalin
1) Confidence 0.81 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3668852 Disease Relevance 0 Pain Relevance 0.95
Exposure to veratridine (3-100 microM) also induced concentration-dependent increases in VIP-LI release, an effect that was Ca(2+)-dependent and tetrodotoxin (TTX)-sensitive.
Localization (release) of VIP associated with tetrodotoxin
2) Confidence 0.78 Published 2001 Journal Neurochem. Int. Section Abstract Doc Link 11137631 Disease Relevance 0 Pain Relevance 0.13
Specific ligands for the L, N, and P/Q-type voltage-operated Ca(2+) channels (VOCCs) were used to determine which channel subtypes were involved in the K(+)-evoked VIP-LI release.
Localization (release) of VIP
3) Confidence 0.78 Published 2001 Journal Neurochem. Int. Section Abstract Doc Link 11137631 Disease Relevance 0 Pain Relevance 0.17
Under conditions of noradrenergic blockade, exposure to high K(+) (40-100 mM) produced dose-dependent increases in the VIP-LI release in a Ca(2+)-dependent manner.
Localization (release) of VIP
4) Confidence 0.78 Published 2001 Journal Neurochem. Int. Section Abstract Doc Link 11137631 Disease Relevance 0 Pain Relevance 0.12
The release of vasoactive intestinal polypeptide (VIP) induced by electrical field stimulation (EFS) of rabbit ileum was studied in vitro.
Localization (release) of VIP in ileum
5) Confidence 0.77 Published 1981 Journal Regul. Pept. Section Abstract Doc Link 7255769 Disease Relevance 0 Pain Relevance 0.08
The aim of this study was to investigate the effect of opioid peptides and depolarizing concentrations of K+ on the release of both vasoactive intestinal polypeptide (VIP) and thyrotropin releasing hormone (TRH) from perifused rat hypothalami.
Localization (release) of VIP associated with opioid
6) Confidence 0.77 Published 1987 Journal Life Sci. Section Abstract Doc Link 3102870 Disease Relevance 0 Pain Relevance 0.54
Toluidine blue improved method (TBI) and immunohistochemistry have also been involved in observations of mucous mast cells in the colon, change of c-fos positive cells, and secretion of SP, SPR, VIP, VIPR in the local colon.
Localization (secretion) of VIP in colon
7) Confidence 0.75 Published 2008 Journal Dig. Dis. Sci. Section Abstract Doc Link 17999187 Disease Relevance 0.31 Pain Relevance 0.43
Regulatory mechanism of electroacupuncture in irritable bowel syndrome: preventing MC activation and decreasing SP VIP secretion.
Localization (secretion) of VIP in bowel associated with spastic colon and electroacupuncture
8) Confidence 0.75 Published 2008 Journal Dig. Dis. Sci. Section Title Doc Link 17999187 Disease Relevance 0.35 Pain Relevance 0.45
The aim of this study was to explore the relationship between the effect of EA on treating IBS rats and the activation and proliferation of mast cell (MC), the secretion of substance P(SP), and vasoactive intestinal polypeptide (VIP).
Localization (secretion) of VIP in mast cell associated with electroacupuncture and substance p
9) Confidence 0.75 Published 2008 Journal Dig. Dis. Sci. Section Abstract Doc Link 17999187 Disease Relevance 0.33 Pain Relevance 0.42
The relaxatory responses elicited by both PACAP-27 and PACAP-38 are abolished by apamin and thus mediated through small conductance Ca2+-activated K+ channels. (3) A VIP-specific receptor localised on smooth muscle cells.
Localization (localised) of VIP in smooth muscle cells
10) Confidence 0.74 Published 1999 Journal Regul. Pept. Section Abstract Doc Link 10651061 Disease Relevance 0 Pain Relevance 0.05
Mucosal HCO3- secretion is thus very probably important in mucosal protection and VIP and endogenous opioid peptides may have a role in its control.
Localization (secretion) of VIP associated with endogenous opioid
11) Confidence 0.73 Published 1985 Journal Dig. Dis. Sci. Section Abstract Doc Link 2932324 Disease Relevance 0 Pain Relevance 0.45
These findings indicate that N and P-type Ca(2+) channels play predominant roles in the high K(+)-evoked release of VIP-LI from the rat hypothalamus.
Localization (release) of VIP in hypothalamus
12) Confidence 0.73 Published 2001 Journal Neurochem. Int. Section Abstract Doc Link 11137631 Disease Relevance 0 Pain Relevance 0.15
The sections were incubated overnight with antisera to tyrosine hydroxylase, choline acetyl transferase, substance P, calcitonin-gene-related peptide, vasoactive intestinal peptide, somatostatin, neuropeptide Y, leucine-enkephalin, cholecystokinin octapeptide, brain-nitric oxide synthase, and endothelium-nitric oxide synthase.
Localization (antisera) of vasoactive intestinal peptide in endothelium
13) Confidence 0.73 Published 2009 Journal Spine Section Body Doc Link 19404173 Disease Relevance 0 Pain Relevance 0
Effects of vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase activating polypeptide (PACAP) on the spontaneous release of acetylcholine from the rat hippocampus by brain microdialysis.
Localization (release) of VIP in hippocampus associated with neuropeptide and hippocampus
14) Confidence 0.72 Published 1993 Journal Brain Res. Section Title Doc Link 8334515 Disease Relevance 0 Pain Relevance 0.31
Isolated perfused segments of canine ileum have no spontaneous motor activity and release large quantities of vasoactive intestinal polypeptide (VIP) continuously.
Localization (release) of VIP in ileum
15) Confidence 0.72 Published 1995 Journal Am. J. Physiol. Section Abstract Doc Link 7631789 Disease Relevance 0 Pain Relevance 0.26
Isolated perfused segments of canine ileum have no spontaneous motor activity and release large quantities of vasoactive intestinal polypeptide (VIP) continuously.
Localization (release) of vasoactive intestinal polypeptide in ileum
16) Confidence 0.72 Published 1995 Journal Am. J. Physiol. Section Abstract Doc Link 7631789 Disease Relevance 0 Pain Relevance 0.26
Somatostatin perfusion was shown to decrease VIP release, accompanied by increased contractions and amplification of responses to low-frequency electrical field stimulation.
Localization (release) of VIP associated with somatostatin
17) Confidence 0.72 Published 1995 Journal Am. J. Physiol. Section Abstract Doc Link 7631789 Disease Relevance 0 Pain Relevance 0.27
VIP is extensively localized in the brain, spinal cord and peripheral neurons, and is especially rich in the nerves innervating the cerebral vasculature.
Localization (localized) of VIP in peripheral neurons associated with spinal cord
18) Confidence 0.71 Published 1991 Journal Zhongguo Yi Xue Ke Xue Yuan Xue Bao Section Abstract Doc Link 1831732 Disease Relevance 0.27 Pain Relevance 0.19
Vasoactive intestinal polypeptide (VIP), but not adenosine 5'-triphosphate (ATP), stimulated protein secretion in a manner almost identical to that observed in response to FS.
Localization (secretion) of VIP associated with adenocard
19) Confidence 0.71 Published 1988 Journal Q J Exp Physiol Section Abstract Doc Link 3347693 Disease Relevance 0.17 Pain Relevance 0.27
It was concluded that VIP was the neurotransmitter responsible for the dominant inhibitory neural input to intestinal circular muscle and that opioid peptides induce phasic contractions by suppressing VIP release.
Localization (release) of VIP in muscle associated with neurotransmitter and opioid
20) Confidence 0.71 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3668852 Disease Relevance 0 Pain Relevance 0.84

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