INT9033

Context Info Confidence 0.39 First Reported 1985 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 14 Total Number 14 Disease Relevance 3.88 Pain Relevance 0.86

lyase activity (Pcbd1) nucleolus (Pcbd1) nucleus (Pcbd1) molecular_function (Pcbd1) cellular_component (Pcbd1) biological_process (Pcbd1)

Anatomy Link Frequency neuronal 1 cerebellar granule cells 1 plasma 1 hepatocyte 1 Pcbd1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat cytokine 8 99.98 agonist 185 99.36 Nicotine 2 89.12 Perioperative pain 1 87.76 Central nervous system 29 76.24 cINOD 26 75.56 Nerve growth factor 8 52.28 Paracetamol 1 25.60 potassium channel 3 25.00 anesthesia 1 25.00

Disease Link Frequency Relevance Heat Apoptosis 229 100.00 Cv Unclassified Under Development 4 99.68 Death 135 97.78 Atherosclerosis 88 95.98 Disease 25 95.40 Umbilical Hernia 4 94.52 Alzheimer's Dementia 12 92.00 Neurodegenerative Disease 14 91.76 Stress 35 90.36 Post Operative Pain 1 87.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The preperitoneal space was dissected to accumulate the underlay patch of the PHS.

Positive_regulation (accumulate) of PHS

1) Confidence 0.39 Published 2003 Journal Hernia Section Abstract Doc Link 12690534 Disease Relevance 0.75 Pain Relevance 0.09

There were minimal changes in the ECG and no change in the level of plasma alpha-hydroxy-butyrate-dehydrogenase, a cardiac specific enzyme which increases during ischaemia.

Positive_regulation (increases) of alpha-hydroxy-butyrate-dehydrogenase in plasma associated with cv unclassified under development

2) Confidence 0.35 Published 1992 Journal J Auton Pharmacol Section Abstract Doc Link 1385437 Disease Relevance 0.19 Pain Relevance 0.04

Eugenol stimulated Fe-PHS activity at low concentrations and inhibited at higher concentrations, an activity typical of many phenolic compounds.

Positive_regulation (stimulated) of Fe-PHS

3) Confidence 0.27 Published 1989 Journal Mol. Pharmacol. Section Abstract Doc Link 2511429 Disease Relevance 0 Pain Relevance 0

Chromatographic analysis of the metabolism of 14C-labeled arachidonic acid in this system revealed that PB-dependent inactivation of PHS is markedly increased in the presence of 100 microM H2O2.

Positive_regulation (increased) of PHS

4) Confidence 0.21 Published 1985 Journal Mol. Pharmacol. Section Abstract Doc Link 3917545 Disease Relevance 0.08 Pain Relevance 0.08

As PB undergoes peroxide-dependent co-oxygenation catalyzed by PHS, we propose that it is an oxygenated derivative of PB, rather than the parent compound, which is responsible for the inactivation of PHS and prostacyclin synthase.

Positive_regulation (inactivation) of PHS

5) Confidence 0.15 Published 1985 Journal Mol. Pharmacol. Section Abstract Doc Link 3917545 Disease Relevance 0 Pain Relevance 0

A precedent event, apoptotic volume decrease (AVD), is ubiquitously observed in various forms of PCD induced by different cellular insults.

Positive_regulation (induced) of PCD associated with apoptosis

6) Confidence 0.05 Published 2008 Journal Current Neuropharmacology Section Abstract Doc Link PMC2647147 Disease Relevance 0.88 Pain Relevance 0

It has been suggested that a dysregulation of MAP kinases is responsible for the growth factor deprivation [15] or chemotherapeutic agent [16] induced PCD.

Positive_regulation (induced) of PCD

7) Confidence 0.04 Published 2001 Journal BMC Pharmacol Section Body Doc Link PMC60650 Disease Relevance 0.22 Pain Relevance 0

agonists were shown to protect cytokine-induced PCD in cerebellar granule cells [59].

Positive_regulation (induced) of PCD in cerebellar granule cells associated with agonist and cytokine

8) Confidence 0.03 Published 2001 Journal BMC Pharmacol Section Body Doc Link PMC60650 Disease Relevance 0.29 Pain Relevance 0.25

During growth factor deprivation induced PCD in neuronal PC12 cells, there is a sustained activation of the JNK and p38 pathways while the activities of ERK pathway is inhibited.

Positive_regulation (induced) of PCD in neuronal

9) Confidence 0.03 Published 2001 Journal BMC Pharmacol Section Body Doc Link PMC60650 Disease Relevance 0.21 Pain Relevance 0.03

It should be noted that addition of cholesterol does not prevent cholesterol oxide induced cell death, which leads to the suggestion that inhibition of cholesterol synthesis is not the cause of cholesterol oxide induced PCD [50,51].

Positive_regulation (induced) of PCD associated with death

10) Confidence 0.02 Published 2001 Journal BMC Pharmacol Section Body Doc Link PMC60650 Disease Relevance 0.17 Pain Relevance 0

PPARs are important in atherosclerosis but the effect of PPAR activation on cholesterol oxide induced PCD has not been determined, this study was designed to test if a dysregulation of MAP kinases was associated with the cholesterol oxide induced PCD, and to determine if PPAR activation could modulate the cholesterol oxide induced PCD.

Positive_regulation (induced) of PCD associated with atherosclerosis

11) Confidence 0.02 Published 2001 Journal BMC Pharmacol Section Body Doc Link PMC60650 Disease Relevance 0.38 Pain Relevance 0.07

PPARs are important in atherosclerosis but the effect of PPAR activation on cholesterol oxide induced PCD has not been determined, this study was designed to test if a dysregulation of MAP kinases was associated with the cholesterol oxide induced PCD, and to determine if PPAR activation could modulate the cholesterol oxide induced PCD.

Positive_regulation (induced) of PCD associated with atherosclerosis

12) Confidence 0.02 Published 2001 Journal BMC Pharmacol Section Body Doc Link PMC60650 Disease Relevance 0.37 Pain Relevance 0.07

activation was shown to suppress both spontaneous rat hepatocyte PCD and the PCD induced by transforming growth factor-?

Positive_regulation (induced) of PCD in hepatocyte

13) Confidence 0.02 Published 2001 Journal BMC Pharmacol Section Body Doc Link PMC60650 Disease Relevance 0.19 Pain Relevance 0.23

Whether cholesterol oxides, the main toxic components in oxidized LDL, can induce MAP kinase activation, and whether MAP kinase activation has a role in cholesterol oxide induced PCD remain to be investigated, and is the subject of this study.

Positive_regulation (induced) of PCD

14) Confidence 0.02 Published 2001 Journal BMC Pharmacol Section Body Doc Link PMC60650 Disease Relevance 0.17 Pain Relevance 0

General Comments

This test has worked.