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Context Info
Confidence 0.78
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 27
Total Number 35
Disease Relevance 14.07
Pain Relevance 4.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gast)
Anatomy Link Frequency
chief cells 2
muscle 2
neck cells 2
parietal cells 2
endocrine cells 2
Gast (Mus musculus)
Pain Link Frequency Relevance Heat
Somatostatin 39 99.98 Very High Very High Very High
gABA 117 99.80 Very High Very High Very High
Inflammatory mediators 10 99.56 Very High Very High Very High
nMDA receptor 108 99.24 Very High Very High Very High
isoflurane 171 98.36 Very High Very High Very High
substance P 3 98.08 Very High Very High Very High
Inflammation 66 97.36 Very High Very High Very High
peptic ulcer disease 15 96.60 Very High Very High Very High
analgesia 27 96.40 Very High Very High Very High
halothane 171 96.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Syndrome 70 99.90 Very High Very High Very High
Targeted Disruption 176 99.88 Very High Very High Very High
Colon Cancer 3 99.36 Very High Very High Very High
Helicobacter Infection 7 99.32 Very High Very High Very High
INFLAMMATION 81 99.16 Very High Very High Very High
Frailty 42 98.68 Very High Very High Very High
Infection 154 98.52 Very High Very High Very High
Ganglion Cysts 9 96.98 Very High Very High Very High
Stomach Cancer 12 96.96 Very High Very High Very High
Ulcers 31 96.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpression of glycine-extended gastrin inhibits parietal cell loss and atrophy in the mouse stomach.
Gene_expression (Overexpression) of gastrin in stomach associated with frailty
1) Confidence 0.78 Published 2004 Journal Cancer Res. Section Title Doc Link 15548680 Disease Relevance 0.69 Pain Relevance 0
Transgenic mice overexpressing amidated gastrin (INS-GAS mice), G-gly (MTI/G-gly mice), and both peptides (INS-GAS/G-gly mice) were used for assessment of acid secretion and ulcer susceptibility and histologic examination and scoring of preneoplastic lesions in response to the 3 and 6 months Helicobacter felis (H. felis) infection.
Gene_expression (overexpressing) of gastrin associated with targeted disruption, ulcers and infection
2) Confidence 0.78 Published 2004 Journal Cancer Res. Section Abstract Doc Link 15548680 Disease Relevance 0.69 Pain Relevance 0
Altered gastrin expression associated with Helicobacter pylori infection may contribute to the pathogenesis of peptic ulcer disease or gastric cancer in man, but gastrin has not been investigated in a murine model of Helicobacter infection.
Gene_expression (expression) of gastrin associated with peptic ulcer disease, helicobacter infection, disease, stomach cancer and infection
3) Confidence 0.77 Published 2000 Journal Dig. Dis. Sci. Section Abstract Doc Link 10961708 Disease Relevance 0.64 Pain Relevance 0.16
Other workers have also observed that Cox-2 inhibition influenced gastrin expression in an in vitro colorectal cancer model [34] and also in H. pylori positive gastric cancer patients [36].
Gene_expression (expression) of gastrin associated with colon cancer and stomach cancer
4) Confidence 0.68 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2667483 Disease Relevance 1.22 Pain Relevance 0.10
A single dose administration of RC-3095 at the highest dose level (96 ug/kg) was tested in a clearly hypergastrinemic individual with the Zollingen-Ellison syndrome and produced a decrease in plasma gastrin down to 50% of basal levels in 6 h.
Gene_expression (produced) of gastrin in plasma associated with syndrome
5) Confidence 0.60 Published 2006 Journal Invest New Drugs Section Abstract Doc Link 16505950 Disease Relevance 0.67 Pain Relevance 0.07
Epithelial cells containing gastrin and somatostatin are found during the early period of gastric and small-intestinal development.
Gene_expression (containing) of gastrin in Epithelial cells associated with somatostatin
6) Confidence 0.58 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2408929 Disease Relevance 0.51 Pain Relevance 0.13
Strategies targeting the vimentin-GAS interaction may prevent or attenuate GAS myonecrosis.
Gene_expression (myonecrosis) of GAS
7) Confidence 0.55 Published 2008 Journal J. Infect. Dis. Section Body Doc Link 18939933 Disease Relevance 0 Pain Relevance 0
Use of NSAIDs should increase suspicion of cryptic GAS infection in patients with increasing pain at sites of nonpenetrating muscle injury.


Gene_expression (infection) of GAS in muscle
8) Confidence 0.55 Published 2008 Journal J. Infect. Dis. Section Body Doc Link 18939933 Disease Relevance 0 Pain Relevance 0
In separate experiments, ketorolac tromethamine (Toradol) was given 1 h before GAS infusion.
Gene_expression (infusion) of GAS
9) Confidence 0.55 Published 2008 Journal J. Infect. Dis. Section Body Doc Link 18939933 Disease Relevance 0 Pain Relevance 0
Transgenic mice overexpressing amidated gastrin (INS-GAS mice), G-gly (MTI/G-gly mice), and both peptides (INS-GAS/G-gly mice) were used for assessment of acid secretion and ulcer susceptibility and histologic examination and scoring of preneoplastic lesions in response to the 3 and 6 months Helicobacter felis (H. felis) infection.
Gene_expression (overexpressing) of INS-GAS associated with targeted disruption, ulcers and infection
10) Confidence 0.53 Published 2004 Journal Cancer Res. Section Abstract Doc Link 15548680 Disease Relevance 0.69 Pain Relevance 0
Gastrin (Gast) is an important mediator in the stomach [30-34] and expression in the mucosa was strongly influenced, not only by infection with H. pylori, but also by suppression of Cox-2 activity (Figure 3, Additional File 1, Table S4).
Gene_expression (expression) of Gast in stomach associated with infection
11) Confidence 0.51 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2667483 Disease Relevance 0.75 Pain Relevance 0.14
Vimentin gene expression and homing of GAS were followed by real-time reverse-transcriptase polymerase chain reaction and quantitative bacteriology of muscle homogenates, respectively.
Gene_expression (expression) of GAS in muscle
12) Confidence 0.49 Published 2008 Journal J. Infect. Dis. Section Body Doc Link 18939933 Disease Relevance 0 Pain Relevance 0
In SSTR2 knockout mice, gastrin and histamine stimulated acid secretion with similar efficacy, while in wild-type mice histamine was more effective than gastrin.
Gene_expression (effective) of gastrin associated with targeted disruption
13) Confidence 0.49 Published 2004 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 15599710 Disease Relevance 0.66 Pain Relevance 0.62
On application of pressures up to 274 atm by increasing the amount of helium (a non-anaesthetic gas at these pressures) in the container, these changes were reversed: S?
Gene_expression (pressures) of gas
14) Confidence 0.19 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989583 Disease Relevance 0 Pain Relevance 0.04
The site of action was not the sympathetic nerves in the superior cervical ganglion (Kendig et al., 1975); nor the neuromuscular junction (Kendig and Cohen, 1976); nor the effect caused by a combination of pentobarbitone, N2O or high-pressure N2 gas and GABA on its receptors (Little and Thomas, 1986).
Gene_expression (pressure) of gas in neuromuscular junction associated with ganglion cysts and gaba
15) Confidence 0.19 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989583 Disease Relevance 0.10 Pain Relevance 0.17
Subsections GABAA receptors and NMDA receptor will briefly review the evidence for grouping GAs into the following classes: (i) haloalkanes; (ii) propofol; (iii) etomidate; (iv) barbiturates; (v) neurosteroids; (vi) xenon and N2O (vii) alkanols.
Gene_expression (grouping) of GAs associated with nmda receptor
16) Confidence 0.19 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989583 Disease Relevance 0 Pain Relevance 0.11
It was not limited to GAs (Halsey and Wardley-Smith, 1975); some other compounds exhibited this effect, and some GAs did not exhibit pressure reversal (Smith et al., 1984).
Neg (not) Gene_expression (limited) of GAs
17) Confidence 0.19 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989583 Disease Relevance 0.09 Pain Relevance 0.17
It would seem that it might be unable to account for the effect of GAs of larger sizes, such as diethyl ether, isoflurane or enflurane.
Gene_expression (effect) of GAs associated with isoflurane
18) Confidence 0.19 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989583 Disease Relevance 0 Pain Relevance 0.14
On application of pressures up to 274 atm by increasing the amount of helium (a non-anaesthetic gas at these pressures) in the container, these changes were reversed: S?
Gene_expression (anaesthetic) of gas
19) Confidence 0.19 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989583 Disease Relevance 0 Pain Relevance 0.04
Because pathways mediating immobility (Sukhotinsky et al., 2005) and analgesia (Sukhotinsky et al., 2007a) also project from the mesopontine tegmental anaesthesia area, they suggested that the mesopontine tegmental anaesthesia area could be important in the effect of GAs.
Gene_expression (effect) of GAs associated with analgesia
20) Confidence 0.17 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989583 Disease Relevance 0.15 Pain Relevance 0.43

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