INT90385

Context Info Confidence 0.00 First Reported 2000 Last Reported 2000 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 1.10 Pain Relevance 0.98

peptidase activity (Ctsl) histone binding (Ctsl) nucleolus (Ctsl) endoplasmic reticulum (EXTL3) vacuole (Ctsl) lysosome (Ctsl)

Anatomy Link Frequency knee joint 1 EXTL3 (Homo sapiens) Ctsl (Mus musculus)

Pain Link Frequency Relevance Heat antagonist 7 99.88 Thermal hyperalgesia 5 95.44 aspirin 1 92.88 Morphine 1 85.76 Hyperalgesia 7 75.00 Inflammation 4 75.00 Potency 2 69.40 Analgesic 2 60.96 withdrawal 2 39.00

Disease Link Frequency Relevance Heat Hyperalgesia 18 99.12 INFLAMMATION 4 75.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In addition to the anti-hyperalgesic effects of NK(1) receptor antagonists, the effects of SDZ NKT 343 and RPR100893 on plasma protein extravasation were measured in the FCA-treated knee joint of the guinea-pig.

RPR100893 Regulation (effects) of NKT in knee joint associated with hyperalgesia and antagonist

1) Confidence 0.00 Published 2000 Journal Pain Section Abstract Doc Link 10963905 Disease Relevance 1.10 Pain Relevance 0.98

General Comments

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