INT90584

Context Info Confidence 0.14 First Reported 2000 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 15 Total Number 17 Disease Relevance 13.81 Pain Relevance 1.86

cytosol (GZMB) peptidase activity (GZMB) nucleus (GZMB) cytoplasm (GZMB)

Anatomy Link Frequency T cells 3 NK cells 2 blood 1 adaptive Treg 1 cytotoxic T-cells 1 GZMB (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 191 99.84 Prostatitis 14 98.52 spinal inflammation 47 97.56 Inflammation 128 92.28 withdrawal 6 75.56 pain pelvic 4 75.00 chemokine 17 65.80 iatrogenic 4 59.20 Pain 5 50.08 cINOD 5 49.04

Disease Link Frequency Relevance Heat Cancer 415 99.92 Necrosis 13 99.64 Leishmaniasis 150 98.90 Prostatitis 14 98.52 Pulmonary Disease 87 97.64 Low Back Pain 53 97.56 Emphysema 7 97.28 Apoptosis 83 97.04 Glioma 50 95.00 Metastasis 11 94.80

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The expression of perforin and granzyme B provided insight into the lytic activity of infiltrating T and NK cells.

Gene_expression (expression) of granzyme B in NK cells

1) Confidence 0.14 Published 2009 Journal J Transl Med Section Body Doc Link PMC2714296 Disease Relevance 0.75 Pain Relevance 0

In fact granzyme B has not been shown to be expressed in naive Treg cells but it is highly expressed in 5%–30% of Tregs in the tumor environment.

Gene_expression (expressed) of granzyme B associated with cancer

2) Confidence 0.13 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2821644 Disease Relevance 0.46 Pain Relevance 0.06

Tregs can also control the immune response mediating the perforin/granzyme pathway; in fact Grossman et al. have shown that human adaptive Treg cells preferentially express granzyme B and can kill allogeneic target cells in a perforin-dependent manner.

Gene_expression (express) of granzyme B in adaptive Treg

3) Confidence 0.13 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2821644 Disease Relevance 0.23 Pain Relevance 0.03

CD8+CD28- T cells have been reported to be effector cells, producing perforin, granzyme B, tumour necrosis factor-?

Gene_expression (producing) of granzyme B in T cells associated with necrosis and cancer

4) Confidence 0.13 Published 2002 Journal Arthritis Res Section Body Doc Link PMC64855 Disease Relevance 1.25 Pain Relevance 0.38

In humans, when Tregs are activated, they express granzyme A, but very little granzyme B [53].

Gene_expression (express) of granzyme B

5) Confidence 0.10 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2821644 Disease Relevance 0.34 Pain Relevance 0.03

We demonstrate an intense infiltration of the affected lymph node by cytotoxic T-cells expressing CD8, perforin, and granzymeB.

Gene_expression (expressing) of granzymeB in cytotoxic T-cells

6) Confidence 0.09 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2853499 Disease Relevance 1.62 Pain Relevance 0.09

Many mechanisms have been proposed for the functional inactivation of tumor associated NK cells including the over-expression of Fas ligand, the loss of mRNA for granzyme B [2] and decreased CD16 and its associated zeta chain [15].

Gene_expression (expression) of granzyme B in NK cells associated with cancer

7) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.97 Pain Relevance 0

Colonocyte-derived products after leptin treatment stimulated perforin and granzyme B expressions in normal CD8 (+) T cells in vitro [68].

Gene_expression (expressions) of granzyme B in T cells

8) Confidence 0.08 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2846344 Disease Relevance 0.44 Pain Relevance 0.24

and granzyme B expression.

Gene_expression (expression) of granzyme B

9) Confidence 0.08 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2952949 Disease Relevance 0.62 Pain Relevance 0.04

Morissette et al did reported, however, no difference in expression of perforin, granzyme B and FasL of CD8+ T lymphocytes in peripheral blood in emphysematous subjects [28], supporting the notion that CD8+ T cells are not activated in the circulation of smokers and subjects with COPD.

Gene_expression (expression) of granzyme B in blood associated with pulmonary disease and nicotine addiction

10) Confidence 0.03 Published 2010 Journal Respir Res Section Body Doc Link PMC2955660 Disease Relevance 1.27 Pain Relevance 0

HO-1 and granzyme B expression was highest in men with category II prostatitis than in men with either category III prostatitis or asymptomatic controls.

Gene_expression (expression) of granzyme B associated with prostatitis

11) Confidence 0.03 Published 2000 Journal J. Androl. Section Abstract Doc Link 10975414 Disease Relevance 1.39 Pain Relevance 0.34

In the third phase, the effector phase, activated donor T cells mediate cytotoxicity against target host cells through Fas-Fas ligand interactions, perforin-granzyme B, and the additional production of cytokines, such as TNF-?

Gene_expression (production) of perforin-granzyme B in T cells associated with cytokine

12) Confidence 0.03 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2018687 Disease Relevance 0.62 Pain Relevance 0.29

Good prognosis in patients with cutaneous leishmaniasis, infected with L. major, has been associated with the expression of granzyme B in tissue lesions [34].

Gene_expression (expression) of granzyme B associated with leishmaniasis

13) Confidence 0.03 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970528 Disease Relevance 0.74 Pain Relevance 0

To determine the mechanism by which CD8 kill MOi, we measured the expression of granzyme B and FasL, before and after cytotoxic challenge with autologous MOi from LCL patients, which were the only ones that had exhibited cytotoxic capacity.

Gene_expression (expression) of granzyme B associated with leishmaniasis

14) Confidence 0.03 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970528 Disease Relevance 0.99 Pain Relevance 0

Thus, compared to their nodal counterparts, ALCLs that present as bone lesions are distinguished by their uniform expression of EMA and granzyme B, and a relatively poor clinical outcome.

Gene_expression (expression) of granzyme B

15) Confidence 0.02 Published 2000 Journal Mod. Pathol. Section Abstract Doc Link 11048810 Disease Relevance 0.66 Pain Relevance 0.05

Total RNA from EPS was used for gene expression of heme oxygenase-1 (HO-1) and granzyme B.

Gene_expression (expression) of granzyme B

16) Confidence 0.02 Published 2000 Journal J. Androl. Section Abstract Doc Link 10975414 Disease Relevance 1.46 Pain Relevance 0.31

In a parallel experiment, the expressions of FasL and Granzyme B were evaluated using Ab anti-FasL – PE (BD) and anti-granzyme – Alexa Fluor 647 (BD).

Gene_expression (expressions) of Granzyme B

17) Confidence 0.01 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970528 Disease Relevance 0 Pain Relevance 0

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