INT90688

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Context Info
Confidence 0.59
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 5.82
Pain Relevance 2.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Tdo2)
Anatomy Link Frequency
liver 2
plasma 1
brain 1
T cell 1
hippocampus 1
Tdo2 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 67 99.70 Very High Very High Very High
Hippocampus 150 99.48 Very High Very High Very High
antidepressant 26 99.18 Very High Very High Very High
Paracetamol 5 98.72 Very High Very High Very High
Eae 82 98.16 Very High Very High Very High
depression 72 97.16 Very High Very High Very High
Analgesic 1 74.84 Quite High
midbrain 32 74.20 Quite High
nMDA receptor antagonist 2 61.12 Quite High
cytokine 20 55.24 Quite High
Disease Link Frequency Relevance Heat
Anxiety Disorder 236 99.64 Very High Very High Very High
Stress 188 97.44 Very High Very High Very High
Depression 74 97.16 Very High Very High Very High
Neurodegenerative Disease 162 84.32 Quite High
Sepsis 4 78.80 Quite High
Targeted Disruption 27 77.80 Quite High
Disease 30 76.80 Quite High
Obesity 8 76.40 Quite High
Tourette's Syndrome 16 75.36 Quite High
Injury 4 74.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In agreement with our data, Yamasaki et al. reported marked reduction of the level of tdo mRNA in the hippocampus of alpha-CaMKII deficient mice (alpha-CaMKII+/-) that show anxiolytic phenotype [31].
Negative_regulation (reduction) of tdo in hippocampus associated with anxiety disorder and hippocampus
1) Confidence 0.59 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0.54 Pain Relevance 0.05
Taken together, these findings demonstrate that the loss of TDO induces the proliferation of both neural progenitors and neural stem cells in the SVZ, and hence might contribute, either fully or partly, to a decrease in the size of the LV.


Negative_regulation (loss) of TDO in neural
2) Confidence 0.51 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0.19 Pain Relevance 0
Further, antidepressants have been postulated to act by directly inhibiting the activity of tryptophan 2,3-dioxygenase (TDO/tryptophan pyrolase) [8-10], one of two rate-limiting enzymes for the kynurenine pathway of Trp metabolism (Figure 1A), in turn enhancing the availability of cerebral Trp [11,12].
Negative_regulation (inhibiting) of TDO associated with antidepressant
3) Confidence 0.43 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0.91 Pain Relevance 0.21
Further, antidepressants have been postulated to act by directly inhibiting the activity of tryptophan 2,3-dioxygenase (TDO/tryptophan pyrolase) [8-10], one of two rate-limiting enzymes for the kynurenine pathway of Trp metabolism (Figure 1A), in turn enhancing the availability of cerebral Trp [11,12].
Negative_regulation (inhibiting) of tryptophan 2,3-dioxygenase associated with antidepressant
4) Confidence 0.43 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0.86 Pain Relevance 0.21
The disruption of tdo was verified by the absence of tdo mRNA transcripts and TDO protein in the liver, as assessed by quantitative real-time PCR and Western blot analyses, respectively (Figure 1D and 1E).
Negative_regulation (absence) of TDO protein in liver
5) Confidence 0.43 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0.71 Pain Relevance 0.03
These results clearly indicate that depletion of TDO induced anxiolytic effects without affecting locomotor activity or the behavioral phenotype of Tdo-/- mice.


Negative_regulation (depletion) of TDO associated with eae and anxiety disorder
6) Confidence 0.38 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0.79 Pain Relevance 0.42
The disruption of tdo was verified by the absence of tdo mRNA transcripts and TDO protein in the liver, as assessed by quantitative real-time PCR and Western blot analyses, respectively (Figure 1D and 1E).
Negative_regulation (disruption) of tdo in liver
7) Confidence 0.38 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0.72 Pain Relevance 0.03
In contrast to our findings for Trp, plasma levels of Kyn and KYNA, which are downstream Trp metabolites generated by TDO (Figure 1), were sustained at physiological levels despite the absence of TDO.
Negative_regulation (absence) of TDO in plasma
8) Confidence 0.37 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0 Pain Relevance 0.07
The expression level of TDO in the DG of CaMKII?
Negative_regulation (level) of TDO
9) Confidence 0.37 Published 2010 Journal Mol Brain Section Body Doc Link PMC2945337 Disease Relevance 0 Pain Relevance 0
Increased intake of tryptophan leads to an acute increase of cerebral 5-HT and/or 5-HIAA in various species [29] and a rapid depletion of tryptophan which results in impaired cerebral 5-HT formation in mammals and humans [29], [53].
Negative_regulation (depletion) of tryptophan
10) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.68 Pain Relevance 0.19
It was demonstrated that increased tryptophan depletion via the IDO1 pathway increases the generation of kynurenines (see Fig. 1) which inhibit T cell responses and cause the development of dendritic cells with tolerogenic properties [22], [27].
Negative_regulation (depletion) of tryptophan in T cell
11) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911374 Disease Relevance 0.42 Pain Relevance 0.13
These results suggest that acetaminophen use is accompanied by changes in brain serotonin levels due to inhibition of hepatic tryptophan-2,3-dioxygenase activity.
Negative_regulation (inhibition) of tryptophan-2 in brain associated with paracetamol and serotonin
12) Confidence 0.04 Published 2000 Journal Life Sci. Section Abstract Doc Link 10983867 Disease Relevance 0 Pain Relevance 0.67

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