INT90743

Context Info Confidence 0.69 First Reported 2000 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 9 Total Number 13 Disease Relevance 2.29 Pain Relevance 6.06

cytosol (Gpd1) mitochondrion (Gpd1) carbohydrate metabolic process (Gpd1) cytoplasm (Gpd1)

Anatomy Link Frequency spinal cord 2 pituitary 1 brain 1 Gpd1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Morphine 16 99.98 narcan 8 99.42 antagonist 8 99.24 Spinal cord 16 99.20 aspirin 8 99.08 opioid receptor 8 99.02 Analgesic 16 97.70 Pain 8 96.88 monoamine 15 84.32 Neurotransmitter 30 83.20

Disease Link Frequency Relevance Heat Convulsion 16 99.04 INFLAMMATION 8 98.80 Pain 8 96.88 Stress 5 96.04 Shock 10 70.12 Urological Neuroanatomy 40 50.00 Repression 10 42.80 Poisoning 20 38.88 Osteogenic Sarcomas 10 36.52 Drug Induced Neurotoxicity 15 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The opioid receptor antagonist naloxone completely blocked morphine induction of GPDH but had no effect on GPDH induction by noxious heat stimulation or metamizol treatment, implicating different mechanisms of GPDH induction.

Positive_regulation (induction) of GPDH associated with antagonist, narcan, opioid receptor and morphine

1) Confidence 0.69 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10987821 Disease Relevance 0.24 Pain Relevance 0.77

The opioid receptor antagonist naloxone completely blocked morphine induction of GPDH but had no effect on GPDH induction by noxious heat stimulation or metamizol treatment, implicating different mechanisms of GPDH induction.

Positive_regulation (induction) of GPDH associated with antagonist, narcan, opioid receptor and morphine

2) Confidence 0.69 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10987821 Disease Relevance 0.23 Pain Relevance 0.76

Surprisingly, administration of analgesic doses of morphine or the nonsteroidal antiinflammatory drugs aspirin, metamizol (dipyrone), and indomethacin also increased GPDH mRNA levels in rat spinal cord.

Positive_regulation (increased) of GPDH in spinal cord associated with aspirin, inflammation, analgesic, spinal cord and morphine

3) Confidence 0.69 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10987821 Disease Relevance 0.25 Pain Relevance 0.71

Nevertheless, in all cases, induction of the GPDH gene requires adrenal steroids and new protein synthesis, as the induction was blocked in adrenalectomized rats and by cycloheximide treatment, respectively.

Positive_regulation (induction) of GPDH gene

4) Confidence 0.69 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10987821 Disease Relevance 0.23 Pain Relevance 0.75

Northern blot and in situ hybridization analysis confirmed the differential display results; they also showed, in a separate model of neuronal activation, that after thermal noxious stimulation of the hind-paws, a similar increase in GPDH mRNA occurs in the areas of somatotopic projection in the lumbar spinal cord.

Positive_regulation (increase) of GPDH in spinal cord associated with spinal cord

5) Confidence 0.69 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10987821 Disease Relevance 0.25 Pain Relevance 0.57

Our results suggest that the induction of the GPDH gene upon peripheral noxious stimulation is related to the endogenous response to pain as it is mimicked by exogenously applied analgesic drugs.

Positive_regulation (induction) of GPDH gene associated with pain and analgesic

6) Confidence 0.69 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10987821 Disease Relevance 0.31 Pain Relevance 0.74

The transcriptional upregulation of glycerol-3-phosphate dehydrogenase 1 (Gpd1) and FK506-binding protein (Fkbp51) mRNA (Table 4, Figure 4) indicate: 1) that pyrethroid exposure activates the hypothalamic-pituitary-adrenal (HPA) axis and 2) that non-neuronal cell populations in the CNS are sensitive to pyrethroids.

Positive_regulation (upregulation) of Gpd1 in pituitary

7) Confidence 0.65 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0 Pain Relevance 0

The potential impact of increased Gpd1 and Fkbp51 expression on the health and function of affected glia, to date, is unclear.

Positive_regulation (increased) of Gpd1

8) Confidence 0.47 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.10 Pain Relevance 0.26

For deltamethrin, both Camk1g and Gpd1 mRNA had maximally induced expression at 3 h followed by persistent elevations at 6 h (Figure 4).

Positive_regulation (induced) of Gpd1

9) Confidence 0.47 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.07 Pain Relevance 0.11

The opioid receptor antagonist naloxone completely blocked morphine induction of GPDH but had no effect on GPDH induction by noxious heat stimulation or metamizol treatment, implicating different mechanisms of GPDH induction.

Positive_regulation (induction) of GPDH associated with antagonist, narcan, opioid receptor and morphine

10) Confidence 0.47 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10987821 Disease Relevance 0.24 Pain Relevance 0.76

Using mRNA differential display, we found that the gene for NAD(+)-dependent glycerol phosphate dehydrogenase (GPDH; EC 1.1.1.8) is induced in rat brain following seizure activity.

Positive_regulation (induced) of phosphate dehydrogenase in brain associated with convulsion

11) Confidence 0.44 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10987821 Disease Relevance 0.24 Pain Relevance 0.44

For permethrin, both Camk1g and Gpd1 had maximal induction at 6 h preceded by slight elevations at 3 h.

Positive_regulation (induction) of Gpd1

12) Confidence 0.43 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.06 Pain Relevance 0.10

Permethrin-mediated Gpd1 induction was statistically significant while Camk1g induction reflected the trends observed in the dose-response cohorts but did not reach statistical significance.

Positive_regulation (induction) of Gpd1

13) Confidence 0.43 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.06 Pain Relevance 0.10

General Comments

This test has worked.