INT90746

Context Info Confidence 0.72 First Reported 2000 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 6 Disease Relevance 0.61 Pain Relevance 1.08

cytosol (Gpd1) mitochondrion (Gpd1) carbohydrate metabolic process (Gpd1) cytoplasm (Gpd1)

Anatomy Link Frequency oligodendrocytes 1 Gpd1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat analgesia 1 99.20 monoamine 15 86.08 Neurotransmitter 30 84.96 Spinal cord 2 79.36 Analgesic 2 77.56 Morphine 2 76.80 Dopamine 20 76.00 Serotonin 10 74.96 aspirin 1 74.72 opioid receptor 1 70.56

Disease Link Frequency Relevance Heat Convulsion 2 99.68 Stress 5 98.00 Osteogenic Sarcomas 10 91.20 INFLAMMATION 1 75.64 Shock 10 61.04 Urological Neuroanatomy 40 50.00 Repression 10 44.56 Poisoning 20 26.04 Drug Induced Neurotoxicity 15 5.00 Neuroblastoma 10 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It is likely that increases in Gpd1 and Fkbp51 expression may be components of a generalized, non-specific stress response brought about by overstimulation of the HPA axis by pyrethroids.

Gene_expression (expression) of Gpd1 associated with stress

1) Confidence 0.72 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.10 Pain Relevance 0.19

The potential impact of increased Gpd1 and Fkbp51 expression on the health and function of affected glia, to date, is unclear.

Gene_expression (expression) of Gpd1

2) Confidence 0.72 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.10 Pain Relevance 0.26

Induction of glycerol phosphate dehydrogenase gene expression during seizure and analgesia.

Gene_expression (expression) of phosphate dehydrogenase associated with convulsion and analgesia

3) Confidence 0.68 Published 2000 Journal J. Neurochem. Section Title Doc Link 10987821 Disease Relevance 0.27 Pain Relevance 0.54

Permethrin-mediated Gpd1 induction was statistically significant while Camk1g induction reflected the trends observed in the dose-response cohorts but did not reach statistical significance.

Gene_expression (induction) of Gpd1

4) Confidence 0.63 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.06 Pain Relevance 0.10

The qRT-PCR expression values for Gpd1 and Fkbp51 closely match those observed in the microarray study.

Gene_expression (expression) of Gpd1

5) Confidence 0.56 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.09 Pain Relevance 0

The proteins encoded by Gpd1 and Fkbp51 are expressed in the brain exclusively in oligodendrocytes [86] and T-cell lymphocytes [87].

Gene_expression (expressed) of Gpd1 in oligodendrocytes

6) Confidence 0.56 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0 Pain Relevance 0

General Comments

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