INT90747

Context Info Confidence 0.43 First Reported 2000 Last Reported 2000 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.25 Pain Relevance 0.77

cytosol (Gpd1) mitochondrion (Gpd1) carbohydrate metabolic process (Gpd1) cytoplasm (Gpd1)

Gpd1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Morphine 2 100.00 narcan 1 99.76 antagonist 1 99.58 opioid receptor 1 99.36 Spinal cord 2 97.88 aspirin 1 94.24 Analgesic 2 91.48 analgesia 1 75.00 Pain 1 61.44

Disease Link Frequency Relevance Heat INFLAMMATION 1 93.68 Convulsion 2 76.72 Pain 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The opioid receptor antagonist naloxone completely blocked morphine induction of GPDH but had no effect on GPDH induction by noxious heat stimulation or metamizol treatment, implicating different mechanisms of GPDH induction.

Negative_regulation (blocked) of Positive_regulation (induction) of GPDH associated with antagonist, narcan, opioid receptor and morphine

1) Confidence 0.43 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10987821 Disease Relevance 0.25 Pain Relevance 0.77

General Comments

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