INT90748

Context Info Confidence 0.69 First Reported 2000 Last Reported 2000 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0.48 Pain Relevance 1.33

cytosol (Gpd1) mitochondrion (Gpd1) carbohydrate metabolic process (Gpd1) cytoplasm (Gpd1)

Anatomy Link Frequency spinal cord 2 Gpd1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Spinal cord 4 97.84 Morphine 4 92.52 Analgesic 4 92.08 narcan 2 91.40 antagonist 2 91.04 opioid receptor 2 90.60 aspirin 2 86.40 Pain 2 77.76 analgesia 2 75.00

Disease Link Frequency Relevance Heat Convulsion 4 90.68 INFLAMMATION 2 88.24 Pain 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Nevertheless, in all cases, induction of the GPDH gene requires adrenal steroids and new protein synthesis, as the induction was blocked in adrenalectomized rats and by cycloheximide treatment, respectively.

Positive_regulation (requires) of Positive_regulation (induction) of GPDH gene

1) Confidence 0.69 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10987821 Disease Relevance 0.23 Pain Relevance 0.75

Northern blot and in situ hybridization analysis confirmed the differential display results; they also showed, in a separate model of neuronal activation, that after thermal noxious stimulation of the hind-paws, a similar increase in GPDH mRNA occurs in the areas of somatotopic projection in the lumbar spinal cord.

Positive_regulation (occurs) of Positive_regulation (increase) of GPDH in spinal cord associated with spinal cord

2) Confidence 0.50 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10987821 Disease Relevance 0.25 Pain Relevance 0.58

General Comments

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