INT90749

Context Info Confidence 0.65 First Reported 2000 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 0.45 Pain Relevance 0.94

cytosol (Gpd1) mitochondrion (Gpd1) carbohydrate metabolic process (Gpd1) cytoplasm (Gpd1)

Anatomy Link Frequency spinal cord 2 Gpd1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Spinal cord 2 99.68 aspirin 1 99.08 Morphine 2 98.06 opioid receptor 1 98.00 Analgesic 2 97.70 antagonist 1 96.72 narcan 1 95.84 bDMF 10 81.80 analgesia 1 75.00 Neurobehavioral 2 65.44

Disease Link Frequency Relevance Heat INFLAMMATION 1 98.80 Convulsion 2 80.64 Shock 4 75.36 Poisoning 8 66.32 Repression 4 54.28 Urological Neuroanatomy 16 50.00 Osteogenic Sarcomas 4 41.76 Stress 2 20.76 Drug Induced Neurotoxicity 6 5.00 Neuroblastoma 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The increased expression of Gpd1 and Fkbp51 mRNA indicates an indirect effect on glia due to non-specific activation of the HPA-axis.

Positive_regulation (increased) of Transcription (expression) of Gpd1

1) Confidence 0.65 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.12 Pain Relevance 0.12

Treatment-related increases in Camk1g and Gpd1 mRNA expression were observed for both deltamethrin and permethrin.

Positive_regulation (increases) of Transcription (expression) of Gpd1

2) Confidence 0.47 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.08 Pain Relevance 0.12

Surprisingly, administration of analgesic doses of morphine or the nonsteroidal antiinflammatory drugs aspirin, metamizol (dipyrone), and indomethacin also increased GPDH mRNA levels in rat spinal cord.

Positive_regulation (increased) of Transcription (levels) of GPDH in spinal cord associated with aspirin, inflammation, analgesic, spinal cord and morphine

3) Confidence 0.47 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10987821 Disease Relevance 0.25 Pain Relevance 0.71

General Comments

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