INT9098

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Context Info
Confidence 0.69
First Reported 1982
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 30
Total Number 31
Disease Relevance 15.77
Pain Relevance 4.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (DBP)
Anatomy Link Frequency
blood 2
poly 1
cerebrospinal fluid 1
skin 1
ACC neurons 1
DBP (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 8 100.00 Very High Very High Very High
Anterior cingulate cortex 53 99.68 Very High Very High Very High
adenocard 4 99.40 Very High Very High Very High
Multiple sclerosis 124 99.16 Very High Very High Very High
Angina 15 99.12 Very High Very High Very High
Inflammation 78 98.68 Very High Very High Very High
Dopamine 100 97.80 Very High Very High Very High
narcan 1 94.40 High High
Catecholamine 10 93.52 High High
long-term potentiation 43 92.68 High High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 57 100.00 Very High Very High Very High
Seborrhea 1 100.00 Very High Very High Very High
Obesity 60 99.76 Very High Very High Very High
Stress 287 99.36 Very High Very High Very High
Disorder Of Lipid Metabolism 59 99.22 Very High Very High Very High
Demyelinating Disease 129 99.16 Very High Very High Very High
Neuromyelitis Optica 81 99.12 Very High Very High Very High
Disease 68 99.12 Very High Very High Very High
Coronary Heart Disease 24 99.12 Very High Very High Very High
INFLAMMATION 94 98.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Smaller increases in SBP, DBP, and HR were seen in all groups after skin incision and sternotomy.
Positive_regulation (increases) of DBP in skin
1) Confidence 0.69 Published 1985 Journal Anesthesiology Section Abstract Doc Link 3159311 Disease Relevance 0.09 Pain Relevance 0.26
Following intubation there were significant (P less than 0.05) increases in SBP in all groups, in DBP in the 5 micrograms/kg group, and in HR in the 5 micrograms/kg and 10 micrograms/kg groups.
Positive_regulation (increases) of DBP
2) Confidence 0.60 Published 1985 Journal Anesthesiology Section Abstract Doc Link 3159311 Disease Relevance 0.09 Pain Relevance 0.21
A one dB(A) increase in noise level in the ICU was associated with an increase of HR, SABP, DABP, and MABP by 0.07 beats/min, 0.58 mmHg, 0.15 mmHg, and 0.53 mmHg on average, respectively (Table 4).
Positive_regulation (increase) of DABP
3) Confidence 0.50 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2972598 Disease Relevance 0.30 Pain Relevance 0
By comparison, mean increases in SBP, DBP, and PR for 10 normotensive subjects at our facility were 12.7 mmHg, 10.5 mmHg, and 7.7 beats/min, respectively.
Positive_regulation (increases) of DBP
4) Confidence 0.49 Published 2007 Journal Biopsychosoc Med Section Body Doc Link PMC2045659 Disease Relevance 1.13 Pain Relevance 0.15
Although consistent increases in SBP and DBP were observed in patients after baseline, these differences were not significant.
Positive_regulation (increases) of DBP
5) Confidence 0.47 Published 2004 Journal J. Urol. Section Body Doc Link 15201780 Disease Relevance 0.05 Pain Relevance 0
Significantly higher levels of urinary DBP were observed in the Cd group compared to the reference group.
Positive_regulation (levels) of DBP
6) Confidence 0.47 Published 2007 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 17347552 Disease Relevance 0.48 Pain Relevance 0.07
SBP, DBP and MAP were significantly increased in the novelty stress and stress periods compared to the resting periods.
Positive_regulation (increased) of DBP associated with stress
7) Confidence 0.45 Published 2005 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1185546 Disease Relevance 1.46 Pain Relevance 0
When expressed as percent change from the resting period, the SBP, DBP, MAP and HR were significantly elevated in the novelty stress and stress periods compared to the control period.
Positive_regulation (elevated) of DBP associated with stress
8) Confidence 0.45 Published 2005 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1185546 Disease Relevance 1.65 Pain Relevance 0
The SI, which provides information about the homogeneity of the antihypertensive effect,20,21 also showed significantly higher values for both SBD and DBP with the valsartan/amlodipine combination.
Positive_regulation (values) of DBP associated with seborrhea
9) Confidence 0.43 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835558 Disease Relevance 0.42 Pain Relevance 0
Similarly, there was an increase in the mean sBP (p < 0.001) and dBP (p = 0.001), as depicted in Figure 2.
Positive_regulation (increase) of dBP
10) Confidence 0.41 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2844382 Disease Relevance 0.15 Pain Relevance 0
The direction of gelsolin and DBP concentration changes in CSF (average values calculated based on 40 MS patients included in each group) suggests the possibility that depletion of CSF gelsolin levels might be compensated for by an increase in DBP concentration (Figure 2), but this statement is not supported by r (r = 0.4242) and p (p < 0.005) values calculated using Pearson's correlation test (it included 24 subjects in which GSN and DBP was analyzed in the same samples) indicating occurrence of positive correlation between those values in the same patients, potentially meaning that in subjects with higher CSF gelsolin concentration, higher DBP concentration is more likely to be observed (Figure 3).


Positive_regulation (increase) of DBP associated with multiple sclerosis
11) Confidence 0.35 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.48 Pain Relevance 0.24
Interestingly, in one recent study, up-regulation of gelsolin and DBP in CSF was reported for a pediatric MS group (n = 12) [35] suggesting that in the course of MS development, cerebrospinal fluid GSN and DBP concentrations may indeed increase in some stage of the disease.
Positive_regulation (increase) of DBP in cerebrospinal fluid associated with multiple sclerosis and disease
12) Confidence 0.35 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.91 Pain Relevance 0.41
Finally, no statistically significant increase in HR, SBP, or DBP was noted with capsaicinoid supplementation (Table 2).
Neg (no) Positive_regulation (increase) of DBP
13) Confidence 0.33 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2912905 Disease Relevance 0 Pain Relevance 0
These two latter aspects, as well as many others (the greater predictive value of the SBP, rather that that of the DBP, the increasing cardiovascular risk parallel with rising BP from values as low as 115/75 mmHg, the results of a multitude of randomized clinical trials), have forged a big quantum leap in our understanding of hypertension and seem to bring about the need for radical change, a real paradigm shift in the way we see and deal with blood pressure and with hypertension.
Positive_regulation (increasing) of DBP in blood associated with hypertension
14) Confidence 0.28 Published 2005 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC1087862 Disease Relevance 0.37 Pain Relevance 0
In addition, DBP increases due to enhanced vasoconstriction.15,19 For the first 2 min of dopa-mine infusion, SBP and DBP showed an identical increase with the HR.
Positive_regulation (increases) of DBP associated with increased venous pressure under development
15) Confidence 0.23 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2852789 Disease Relevance 0.10 Pain Relevance 0.13
10 mmHg) and to sustained hand grip (increase in diastolic blood pressure [DBP]; normal values ?
Positive_regulation (increase) of DBP in blood
16) Confidence 0.22 Published 2010 Journal Diabetologia Section Body Doc Link PMC2910895 Disease Relevance 0.19 Pain Relevance 0
The SBP, DBP, MAP and HR increased with 15.2 ± 8.9%, 13.5 ± 9.4%, 14,3 ± 8.5% and 10.2 ± 11.6%, respectively in the stress period and with 12.4 ± 7.5%, 9.3 ± 9.4%, 10.6 ± 7.9% and 9.9 ± 12.6%, respectively, in the novelty stress period compared to the resting period (Figure 3).


Positive_regulation (increased) of DBP associated with stress
17) Confidence 0.20 Published 2005 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1185546 Disease Relevance 1.54 Pain Relevance 0
In addition, DBP increases due to enhanced vasoconstriction.15,19 For the first 2 min of dopa-mine infusion, SBP and DBP showed an identical increase with the HR.
Positive_regulation (increases) of DBP associated with increased venous pressure under development
18) Confidence 0.19 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2852789 Disease Relevance 0.10 Pain Relevance 0.13
In addition, DBP increases due to enhanced vasoconstriction.15,19 For the first 2 min of dopa-mine infusion, SBP and DBP showed an identical increase with the HR.
Positive_regulation (enhanced) of DBP associated with increased venous pressure under development
19) Confidence 0.19 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2852789 Disease Relevance 0.10 Pain Relevance 0.13
MEASUREMENTS AND MAIN RESULTS: No significant differences were found between the methods in the frequency of elevated SBP, elevated DBP, and tachycardia.
Positive_regulation (elevated) of DBP
20) Confidence 0.18 Published 1992 Journal J Clin Anesth Section Body Doc Link 1389193 Disease Relevance 0 Pain Relevance 0

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