INT91147

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Context Info
Confidence 0.69
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 30
Total Number 31
Disease Relevance 19.31
Pain Relevance 5.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ppara) nucleus (Ppara) DNA binding (Ppara)
lipid metabolic process (Ppara)
Anatomy Link Frequency
macrophages 5
liver 4
cardiomyocyte 2
heart 2
A-2 2
Ppara (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 399 99.98 Very High Very High Very High
Inflammation 442 99.52 Very High Very High Very High
Paracetamol 19 98.88 Very High Very High Very High
Endocannabinoid 62 98.80 Very High Very High Very High
Eae 18 97.76 Very High Very High Very High
antagonist 49 93.52 High High
fibrosis 147 92.40 High High
cytokine 103 92.40 High High
COX2 14 91.36 High High
Antihyperalgesic 1 90.36 High High
Disease Link Frequency Relevance Heat
Obesity 358 100.00 Very High Very High Very High
Diabetes Mellitus 127 100.00 Very High Very High Very High
Neurodegenerative Disease 33 100.00 Very High Very High Very High
Stress 88 99.82 Very High Very High Very High
Cancer 454 99.60 Very High Very High Very High
INFLAMMATION 510 99.52 Very High Very High Very High
Hepatotoxicity 15 99.18 Very High Very High Very High
Repression 18 99.12 Very High Very High Very High
Targeted Disruption 183 99.06 Very High Very High Very High
Disorder Of Lipid Metabolism 380 98.38 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is evident that DNA-damaging oxidants are generated by enzymes induced after activation of PPAR?
Positive_regulation (induced) of Positive_regulation (activation) of PPAR
1) Confidence 0.69 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.34 Pain Relevance 0
Fenofibrate not only elevated the transcriptional activation of PPAR?
Positive_regulation (elevated) of Positive_regulation (activation) of PPAR
2) Confidence 0.69 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 0.99 Pain Relevance 0
According to Yoon et al. [20], fenofibrate elevated the transcriptional activation of PPAR?
Positive_regulation (elevated) of Positive_regulation (activation) of PPAR
3) Confidence 0.69 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 0.63 Pain Relevance 0
The insulin-resistant and diabetic heart is characterized by increased fatty acid oxidation rates that may be related to chronic stimulation of the PPAR?
Positive_regulation (related) of Positive_regulation (stimulation) of PPAR in heart associated with diabetes mellitus
4) Confidence 0.50 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1570084 Disease Relevance 1.05 Pain Relevance 0
Based on these observations, it is concluded that chronic exposure to synthetic peroxisome proliferators results in sustained activation of PPAR?
Positive_regulation (results) of Positive_regulation (activation) of PPAR
5) Confidence 0.50 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.40 Pain Relevance 0
These findings demonstrate that the protection against APAP hepatotoxicity by peroxisome proliferator treatment is mediated by the activation of PPARalpha.
Positive_regulation (mediated) of Positive_regulation (activation) of PPARalpha associated with paracetamol and hepatotoxicity
6) Confidence 0.50 Published 2000 Journal Toxicol. Sci. Section Abstract Doc Link 11006363 Disease Relevance 0.55 Pain Relevance 0.69
ligand binding domain directly and induce transcriptional activation of PPAR?
Positive_regulation (induce) of Positive_regulation (activation) of PPAR
7) Confidence 0.49 Published 2007 Journal PPAR Research Section Body Doc Link PMC2220031 Disease Relevance 0 Pain Relevance 0.06
ligands in modulating the radiation-induced microglial proinflammatory response, along with the negative correlation between microglial activation and hippocampal neurogenesis, led to the hypothesis that activation of PPAR?
Positive_regulation (induced) of Positive_regulation (activation) of PPAR associated with neurodegenerative disease
8) Confidence 0.49 Published 2010 Journal PPAR Research Section Body Doc Link PMC2748193 Disease Relevance 0.56 Pain Relevance 0.24
Remarkably, also AP-1-mediated gene transcription depends on the loss of NCoR complexes, suggesting a similar mechanism of PPAR?
Positive_regulation (suggesting) of Positive_regulation (mechanism) of PPAR
9) Confidence 0.48 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443396 Disease Relevance 0.27 Pain Relevance 0.14
significant excitement about a potential role of PPAR?
Positive_regulation (excitement) of Positive_regulation (role) of PPAR
10) Confidence 0.44 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408682 Disease Relevance 1.03 Pain Relevance 0.18
differentiation markers resulting from ligand activation of PPAR?
Positive_regulation (resulting) of Positive_regulation (activation) of PPAR
11) Confidence 0.44 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408682 Disease Relevance 0.36 Pain Relevance 0.09
Stress stimuli exert an increase in PPAR?
Positive_regulation (exert) of Positive_regulation (increase) of PPAR associated with stress
12) Confidence 0.41 Published 2010 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2858266 Disease Relevance 0.19 Pain Relevance 0.13
activation through activation of PPAR-?
Positive_regulation (activation) of Positive_regulation (activation) of PPAR
13) Confidence 0.38 Published 2008 Journal PPAR Research Section Body Doc Link PMC2441778 Disease Relevance 0.15 Pain Relevance 0.05
Furthermore, agonist-induced activation of PPAR?
Positive_regulation (induced) of Positive_regulation (activation) of PPAR associated with agonist
14) Confidence 0.37 Published 2008 Journal PPAR Research Section Body Doc Link PMC2293414 Disease Relevance 0.90 Pain Relevance 0.37
Although OEA is a (albeit relatively low-affinity) CB receptor agonist and could enhance the activity of other endocannabinoids via an “entourage” effect by inhibiting the metabolism of other endocannabinoids, its regulation of feeding behaviour in rats appears to be due to its activation on PPAR?
Positive_regulation (due) of Positive_regulation (activation) of PPAR associated with endocannabinoid and agonist
15) Confidence 0.35 Published 2007 Journal PPAR Research Section Body Doc Link PMC2220031 Disease Relevance 0.64 Pain Relevance 0.26
are upregulated in activated microglia and macrophages [35, 39, 40] and activation of PPAR?
Positive_regulation (upregulated) of Positive_regulation (activation) of PPAR in macrophages
16) Confidence 0.35 Published 2008 Journal PPAR Research Section Body Doc Link PMC2288640 Disease Relevance 1.07 Pain Relevance 0.35
Although increased cardiac OPN expression could result from increased macrophage accumulation, isolated cPPAR??
Positive_regulation (increased) of Positive_regulation (accumulation) of cPPAR in macrophage
17) Confidence 0.33 Published 2008 Journal Diabetes Section Body Doc Link PMC2518499 Disease Relevance 0.65 Pain Relevance 0.18
Several in vivo and in vitro studies have reported increased expression of VEGF in response to PPAR-?
Positive_regulation (reported) of Positive_regulation (response) of PPAR
18) Confidence 0.32 Published 2008 Journal PPAR Research Section Body Doc Link PMC2276614 Disease Relevance 0.77 Pain Relevance 0.11
ligands are also cardiomyocyte protective in diabetes and obesity and whether weaker insulin-sensitizing PPAR?
Spec (whether) Positive_regulation (protective) of Spec (whether) Positive_regulation (insulin-sensitizing) of PPAR in cardiomyocyte associated with diabetes mellitus and obesity
19) Confidence 0.31 Published 2008 Journal Diabetes Section Body Doc Link PMC2518499 Disease Relevance 1.27 Pain Relevance 0.46
We have demonstrated that the inhibition of inflammatory pain behaviour associated with the increase in levels of AEA and NAEs, produced by inhibition of FAAH and COX-2, is mediated at least in part through activation of PPAR-?
Positive_regulation (mediated) of Positive_regulation (activation) of PPAR associated with eae
20) Confidence 0.28 Published 2009 Journal Mol Pain Section Body Doc Link PMC2770047 Disease Relevance 0.22 Pain Relevance 0.66

General Comments

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