INT91210

Context Info Confidence 0.41 First Reported 2000 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 2.76 Pain Relevance 0.52

signal transduction (Mrgpre) plasma membrane (Mrgpre) molecular_function (Mrgpre) cellular_component (Mrgpre) biological_process (Mrgpre) signal transducer activity (Mrgpre)

Mrgpre (Mus musculus)

Pain Link Frequency Relevance Heat Pain 23 100.00 Bile 3 75.00 Neuropathic pain 3 66.72 allodynia 17 5.00 Eae 11 5.00 Sciatic nerve 11 5.00 Spinal cord 9 5.00 fibrosis 5 5.00 agonist 5 5.00 withdrawal 4 5.00

Disease Link Frequency Relevance Heat Pain 25 100.00 Prostate Cancer 56 99.02 Recurrence 15 96.64 Nociception 4 96.52 Pancreatic Cancer 3 94.92 Cancer 48 87.52 Bile Duct Neoplasms 2 69.40 Sarcoma 35 68.96 Neuropathic Pain 22 66.72 Gallstones 1 61.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

EBRT is indicated at best for local pain control and is limited by the high radiation sensitivity of the adjacent organs.

Negative_regulation (limited) of EBRT associated with pain

1) Confidence 0.41 Published 2000 Journal Praxis Section Abstract Doc Link 11014129 Disease Relevance 0.77 Pain Relevance 0.21

We generated mutant mice lacking MrgE and examined the effects of deletion of this gene in three pain behavioural models.

Negative_regulation (lacking) of MrgE associated with pain

2) Confidence 0.38 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2242784 Disease Relevance 0.53 Pain Relevance 0.32

brachytherapy, two patients declined EBRT, and one patient died of

Negative_regulation (declined) of EBRT

3) Confidence 0.19 Published 2006 Journal Sarcoma Section Body Doc Link PMC1557794 Disease Relevance 0.63 Pain Relevance 0

The issue of RT–HT in low-risk PC patients was also indirectly addressed by a retrospective analysis conducted by Ciezki et al.28 The study included 1,668 patients with low- and intermediate-risk PC treated at The Cleveland Clinic Foundation with EBRT, RP, or prostate brachytherapy with or without androgen deprivation during 1996–2001.

Negative_regulation (deprivation) of EBRT associated with prostate cancer

4) Confidence 0.12 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004567 Disease Relevance 0.83 Pain Relevance 0

General Comments

This test has worked.