INT9125

Context Info Confidence 0.79 First Reported 1990 Last Reported 1992 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 0.43 Pain Relevance 0.84

cytosol (Hal) lyase activity (Hal) biosynthetic process (Hal) cytoplasm (Hal)

Anatomy Link Frequency liver 2 blood 1 Hal (Rattus norvegicus)

Pain Link Frequency Relevance Heat narcan 16 99.70 Enkephalin 3 86.16 antagonist 1 76.52 Serotonin 1 76.08 Neuropeptide 2 72.08

Disease Link Frequency Relevance Heat Gallstones 6 75.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A combined injection of dalargin and naloxone promoted high release of histidase and urokaninase in blood and did not change histidase activity in the liver in all cases.

Localization (release) of histidase in liver associated with narcan

1) Confidence 0.79 Published 1992 Journal Biull Eksp Biol Med Section Abstract Doc Link 1391860 Disease Relevance 0.14 Pain Relevance 0.36

Dalargin injection elucidated a marked tendency to lowering of blood release of the liver-specific enzymes histidase and urokaninase in line with enhancement of their activity in the liver.

Localization (release) of histidase in liver

2) Confidence 0.79 Published 1992 Journal Biull Eksp Biol Med Section Abstract Doc Link 1391860 Disease Relevance 0.14 Pain Relevance 0.34

The administration of dalargin reveals a distinct tendency towards reduction of the release of the hepatospecific enzymes histidase and urokanase into the blood and increase of their activity in the hepatic tissue.

Localization (release) of histidase in blood

3) Confidence 0.75 Published 1990 Journal Patol Fiziol Eksp Ter Section Abstract Doc Link 2080086 Disease Relevance 0.15 Pain Relevance 0.15

General Comments

This test has worked.