INT91274

Context Info Confidence 0.42 First Reported 2000 Last Reported 2007 Negated 0 Speculated 0 Reported most in Title Documents 2 Total Number 2 Disease Relevance 1.12 Pain Relevance 0.74

extracellular space (Il2) extracellular region (Il2)

Anatomy Link Frequency locus coeruleus 2 prefrontal 2 Il2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat narcan 2 100.00 Pain 2 100.00 withdrawal 1 100.00 Locus ceruleus 6 99.60 cerebral cortex 9 97.80 Intracerebroventricular 1 88.96 Dorsal horn 1 80.32 Neurotransmitter 1 77.36 amygdala 2 74.24 opioid receptor 1 67.80

Disease Link Frequency Relevance Heat Nociception 4 100.00 Anxiety Disorder 85 98.60 Cancer 1 84.56 Necrosis 1 84.08 Targeted Disruption 2 81.08 Hypertrophy 1 38.88 Syndrome 3 21.32 Endometriosis (extended) 10 20.04 Depression 6 11.76 Hyperlipidemia 2 5.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Furthermore, a decrease in open arm time and an increase in IL-2 level in the prefrontal cortex of LA OVX rats were seen after treatment with dioscorea at 250 mg/kg/day.

Negative_regulation (decrease) of Positive_regulation (increase) of IL-2 in prefrontal associated with anxiety disorder

1) Confidence 0.42 Published 2007 Journal Ann Gen Psychiatry Section Body Doc Link PMC1971263 Disease Relevance 0.84 Pain Relevance 0.17

Inhibition of nociceptive withdrawal reflex by microinjection of interleukin 2 into rat locus coeruleus.

Negative_regulation (Inhibition) of Positive_regulation (microinjection) of interleukin 2 in locus coeruleus associated with nociception, locus ceruleus, narcan and withdrawal

2) Confidence 0.27 Published 2000 Journal Neuropeptides Section Title Doc Link 11021983 Disease Relevance 0.28 Pain Relevance 0.57

General Comments

This test has worked.