INT91327

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Context Info
Confidence 0.67
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 8.55
Pain Relevance 4.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCL4) extracellular space (CCL4) extracellular region (CCL4)
cell adhesion (CCL4) cell-cell signaling (CCL4)
Anatomy Link Frequency
macrophage 3
plasma 3
blood 2
PNS 1
microglial cells 1
CCL4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuritis 12 99.92 Very High Very High Very High
chemokine 169 99.74 Very High Very High Very High
Inflammation 136 99.48 Very High Very High Very High
Sciatic nerve 3 99.44 Very High Very High Very High
cytokine 72 96.10 Very High Very High Very High
Peripheral nervous system 7 95.16 Very High Very High Very High
cINOD 7 90.00 High High
Multiple sclerosis 2 88.00 High High
Inflammatory mediators 9 82.44 Quite High
Pain 3 80.84 Quite High
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 11 99.92 Very High Very High Very High
Disorders Of Creatine Metabolism 5 99.58 Very High Very High Very High
INFLAMMATION 154 99.48 Very High Very High Very High
Disease 55 99.48 Very High Very High Very High
Adenocarcinoma 183 99.40 Very High Very High Very High
Immunization 1 98.68 Very High Very High Very High
Drug Induced Neurotoxicity 2 97.82 Very High Very High Very High
Critical Illness 74 95.36 Very High Very High Very High
Influenza Virus Infection 30 94.48 High High
Necrosis 2 90.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mRNAs for MIP-1alpha and MIP-1beta were found to be upregulated with peak values at day 13 post-immunization (p.i.), preceding maximum disease severity.
Positive_regulation (upregulated) of MIP-1beta associated with immunization and disease
1) Confidence 0.67 Published 2000 Journal J. Neuroimmunol. Section Abstract Doc Link 11024541 Disease Relevance 0.76 Pain Relevance 0.59
However, serum levels of IL-6, CCL2 monocyte chemoattractant protein-1 (MCP-1), CCL3 [macrophage inflammatory protein-1alpha (MIP-1alpha)] and CCL4 (MIP-1beta) were markedly elevated.
Positive_regulation (elevated) of MIP-1beta in macrophage associated with inflammation
2) Confidence 0.67 Published 2009 Journal International journal of laboratory hematology Section Abstract Doc Link 18177436 Disease Relevance 0.73 Pain Relevance 0.17
CPK was correlated with changes in IL-6, G-CSF, IL-10, IL-1ra, and MCP-1 (r = .49-.68), (P < .001), but not IL-8 or MIP-1beta.
Positive_regulation (changes) of MIP-1beta associated with disorders of creatine metabolism
3) Confidence 0.49 Published 2005 Journal Brain Behav. Immun. Section Abstract Doc Link 16061149 Disease Relevance 0.67 Pain Relevance 0.65
Increased MIP-1beta and IP-10 in sciatic nerves may compensate the CCR5 deficiency and contribute to inflammatory cells infiltrating to the PNS.
Positive_regulation (Increased) of MIP-1beta in PNS associated with peripheral nervous system, inflammation and sciatic nerve
4) Confidence 0.49 Published 2004 Journal Neurobiol. Dis. Section Abstract Doc Link 15262275 Disease Relevance 1.14 Pain Relevance 1.14
However, serum levels of IL-6, CCL2 monocyte chemoattractant protein-1 (MCP-1), CCL3 [macrophage inflammatory protein-1alpha (MIP-1alpha)] and CCL4 (MIP-1beta) were markedly elevated.
Positive_regulation (elevated) of CCL4 in macrophage associated with inflammation
5) Confidence 0.43 Published 2009 Journal International journal of laboratory hematology Section Abstract Doc Link 18177436 Disease Relevance 0.73 Pain Relevance 0.17
We identified higher plasma levels of IL1RA, IL2, IL6, CCL3, CCL4 and IL10 as markers of severity.
Positive_regulation (levels) of CCL4 in plasma
6) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 1.02 Pain Relevance 0.23
The disease severity correlated with increased plasma levels of IL1RA, IL2, IL6, CCL3, CCL4 and IL10.
Positive_regulation (increased) of CCL4 in plasma associated with disease
7) Confidence 0.31 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2948498 Disease Relevance 0.59 Pain Relevance 0.07
Representative CC chemokines are CCL2 (also called monocyte chemotactic protein, MCP-1), CCL3 and CCL4 (macrophage inflammatory protein MIP-1?
Positive_regulation (called) of CCL4 in macrophage associated with chemokine and inflammation
8) Confidence 0.24 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 0.10 Pain Relevance 0.37
By expanding our search for the expression of cytokines and chemokines that were potentially relevant to B. burgdorferi-induced neurotoxicity we found that in addition to IL-6, IL-8 and TNF, the four well known proinflammatory chemokines CCL2, CCL3, CCL4 and CCL5 were significantly upregulated in microglial cells co-cultured with B. burgdorferi.
Positive_regulation (upregulated) of CCL4 in microglial cells associated with chemokine, drug induced neurotoxicity and cytokine
9) Confidence 0.16 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2771360 Disease Relevance 0.90 Pain Relevance 0.42
RESULTS: Significantly increased levels of cytokines (IL-1alpha, IL-1beta, IL-6, IL-10, IL12p70) and chemokines (CCL1, CCL3, CCL4, CCL17, CCL22, CXCL8/IL-8) were observed in seminal plasmas from patients with CP/CPPS or BPH.
Positive_regulation (increased) of CCL4 in plasmas
10) Confidence 0.10 Published 2007 Journal Eur. Urol. Section Body Doc Link 16905241 Disease Relevance 0.38 Pain Relevance 0
Further, comparative analysis by semiquantitative RT-PCR analysis was performed for other CXC/CC chemokines (CXCL9, CXCL11, CCL3, CCL4, CCL5) and receptor (CCR5) which revealed their upregulation in the diseased state.
Positive_regulation (upregulation) of CCL4
11) Confidence 0.03 Published 2007 Journal Pancreatology Section Body Doc Link 17912012 Disease Relevance 0.06 Pain Relevance 0
As shown previously by us, the inflammatory profile in blood showed significant increased CXCL8 and PGE2 but also elevated levels of other factors, such as MCP-1, MIP-1b, and IP-10 in PDAC patients [14], that could be of relevance for the semi maturation of MDCs and PDCs seen ex vivo.
Positive_regulation (increased) of MIP-1b in blood associated with adenocarcinoma and inflammation
12) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.74 Pain Relevance 0.15
As shown previously by us, the inflammatory profile in blood showed significant increased CXCL8 and PGE2 but also elevated levels of other factors, such as MCP-1, MIP-1b, and IP-10 in PDAC patients [14], that could be of relevance for the semi maturation of MDCs and PDCs seen ex vivo.
Positive_regulation (elevated) of MIP-1b in blood associated with adenocarcinoma and inflammation
13) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.73 Pain Relevance 0.15

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